Designing, preparation and evaluation of the antimicrobial activity of biomaterials based on chitosan modified with silver nanoparticles

Elmehbad, Noura Y.; Mohamed, Nadia A.

doi:10.1016/j.ijbiomac.2020.01.298

Cited by 53 publications

(30 citation statements)

References 42 publications

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“…Cellulose in these composite hydrogel behaved as a bridge between PPO/PEO by H‐bonds and the metallic nanostructure, providing a good support for preparing PPO/PEO‐C@Ag hybrid nanocomposite hydrogels. Similar explanations are obtained during the synthesis of Novel amino salicylic acid chitosan derivative and its AgNP composites 62 …”

Section: Resultssupporting

confidence: 73%

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Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L-929 (ATCC CCL-1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

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Section: Resultssupporting

confidence: 73%

“…Similar explanations are obtained during the synthesis of Novel amino salicylic acid chitosan derivative and its AgNP composites. 62…”

Section: Xps Analysismentioning

confidence: 99%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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“…Chitosan is derived from chitin ( Figure ), the second most abundant natural biopolymer after cellulose, and has a high cationic potential. [ 60,61 ] Chitin forms the exoskeleton of many living organisms, including crabs, shrimps, insects, and cell walls of fungi. [ 62 ] Chitosan has favorable physicochemical and biological properties, such as biodegradability, biocompatibility, bioactivity, high permeability, and non‐toxicity.…”

Section: Chitosan Nanoparticles (Csnps)mentioning

confidence: 99%

New Perspectives of Using Chitosan, Silver, and Chitosan–Silver Nanoparticles against Multidrug‐Resistant Bacteria

Polinarski

Beal

Silva

et al. 2021

Part & Part Syst Charact

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materials are typically developed at a critical length of under 100 nm. However, other phenomena, such as transparency and stable dispersion, can occasionally extend the upper limit, and the use of the prefix "nano" is accepted for dimensions smaller than 500 nm. [2] Two relevant factors differentiate nanomaterials from macroscopic materials: first, the quantum effect that can promote changes in physical properties, such as color and electrical conductivity, and second, the surface effect related to the increased surface area to volume ratio that favors physical and chemical interactions between atoms and the surrounding environment. [3] NPs are of the same order of magnitude as antibodies, membrane receptors, nucleic acids, proteins, and other biomolecules, thus representing a potential material to be used in medicine for imaging applications, diagnosis, therapies, or in medical devices. [4] The small size and large surface area of NPs facilitate their permeation through cell membranes and enhance their biological activity. [5] Microbial colonization of medical devices leads to the formation of microbial or fungal biofilms, which are complex assemblages of microbial cells associated with a surface and incorporated into an extracellular matrix. [6] Biofilms are critical clinical issues because they culminate in the pathogenesis of numerous bacterial infections that are difficult to treat and effectively eradicate with antibiotics. [7] Biofilm formation can occur in three stages: attachment, maturation, and dispersion. The attachment step can be further categorized in two-stage processes: initial reversible attachment and irreversible attachment, in which the attached biofilm can tolerate strong shear forces. [8] The bacteria deposition is mediated by sedimentation, Brownian motion, and hydrodynamic forces, whereas adhesion is governed by Van der Waals, acid-base, hydrophobic, and electrostatic interaction forces. [9] Attachment is the most crucial phase to prevent bacterial adhesion because the antimicrobial action becomes less effective after biofilm formation. [10] Medical devices commonly affected by microbial contamination and biofilm formation are catheters, probes, and wound dressings. Catheters are used in patients to administer fluids, blood products, and parenteral nutrition. [6] Most nosocomial infections in intensive care units (ICUs) are associated with the insertion and maintenance of central venous catheters Nanomaterials with antimicrobial activity are promising alternatives to overcome microbial resistance in medical devices. Catheters, probes, and wound dressings are among the medical devices mostly affected by microbial contamination and the formation of polymicrobial biofilms. Nanoparticles (NPs) derived from natural sources, such as chitosan nanoparticles (CsNPs), and metal-based nanoparticles, including silver nanoparticles (AgNPs), are receiving increased interest in nanomedicine. CsNPs have been widely explored as a coating material and antimicrobial agent. AgNPs have a strong antimicrobi...

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“…Natural, abundant polysaccharides are attractive biomaterials for various applications such as food wrapper, tissue engineering scaffolds, drug delivery vehicles, flocculating agents, and cosmetics, due to their non-toxicity, biocompatibility, and biodegradability properties [1]. In this regard, chitosan, as a natural polysaccharide, has a particularly extensive prospect in application of biomaterials [2,3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

Zhang

Tan

et al. 2020

Marine Drugs

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Chitosan is an active biopolymer, and the combination of it with other active groups can be a valuable method to improve the potential application of the resultant derivatives in food, cosmetics, packaging materials, and other industries. In this paper, a series of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives were synthesized. The combination of chitosan with ureidopyridinium group and quaternary ammonium group made it achieve developed water solubility and biological properties. The structures of chitosan and chitosan derivatives were confirmed by FTIR, 1H NMR spectra, and elemental analysis. The prepared chitosan derivatives were evaluated for antioxidant property by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical scavenging ability, and superoxide radical scavenging ability. The results revealed that the synthesized chitosan derivatives exhibited improved antioxidant activity compared with chitosan. The chitosan derivatives were also investigated for antifungal activity against Phomopsis asparagus as well as Botrytis cinerea, and they showed a significant inhibitory effect on the selected phytopathogen. Meanwhile, CCK-8 assay was used to test the cytotoxicity of chitosan derivatives, and the results showed that most derivatives had low toxicity. These data suggested to develop analogs of chitosan derivatives containing ureidopyridinium group and quaternary ammonium group, which will provide a new kind of promising biomaterials having decreased cytotoxicity as well as excellent antioxidant and antimicrobial activity.

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Designing, preparation and evaluation of the antimicrobial activity of biomaterials based on chitosan modified with silver nanoparticles

Cited by 53 publications

References 42 publications

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

New Perspectives of Using Chitosan, Silver, and Chitosan–Silver Nanoparticles against Multidrug‐Resistant Bacteria

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

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