Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress

Xie, Xiaoxian; Chen, Yangyang; Wang, Qi; Shen, Qichen; Ma, Lingyan; Huang, Liangfeng; Wu, Tao; Fu, Zhengwei

doi:10.1016/j.lfs.2017.08.020

Cited by 8 publications

(8 citation statements)

References 40 publications

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“…In animal models of depressive-like behavior, reduced TERT expression has been reported in tissues such as the liver and hippocampus [55–57], but this study is the first to show a significant decrease in three major brain regions (the hippocampus, striatum, and prefrontal cortex) involved in depression (Figure 6). This pronounced decrease (between 25% to 50%) of the de novo synthesis of TERT may be partially responsible for the long-term deleterious consequences associated with depression, such as accelerated brain aging and increased susceptibility to age-related disorders.…”

Section: Discussionmentioning

confidence: 69%

Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice

Souza-Monteiro

Arrifano

Queiroz

et al. 2019

Oxidative Medicine and Cellular Longevity

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Depression is a mental disorder that affects 300 million people of all ages worldwide, but fewer than half of those with the condition receive adequate treatment. In addition, the high pharmacological refractoriness (affecting 30%-50% of patients) and toxicity of some classical antidepressants support the pursuit of new therapies. People with this condition show depressed mood, loss of pleasure, high levels of oxidative stress, and accelerated biological aging (decreased telomere length and expression of the telomerase reverse transcriptase (TERT), the enzyme responsible for telomere maintenance). Because of the close relationship between depression and oxidative stress, nutraceuticals with antioxidant properties are excellent candidates for therapy. This study represents the first investigation of the possible antidepressant and antiaging effects of commercial samples of clarified açaí (Euterpe oleracea) juice (EO). This fruit is rich in antioxidants and widely consumed. In this study, mice were treated with saline or EO (10 μL/g, oral) for 4 days and then with saline or lipopolysaccharide (0.5 mg/kg, i.p.) to induce depressive-like behavior. Only four doses of EO were enough to abolish the despair-like and anhedonia behaviors and alterations observed in electromyographic measurements. The antidepression effect of EO was similar to that of imipramine and associated with antioxidant and antiaging effects (preventing lipid peroxidation and increasing TERT mRNA expression, respectively) in three major brain regions involved in depression (hippocampus, striatum, and prefrontal cortex). Additionally, EO significantly protected hippocampal cells, preventing neuronal loss associated with the depressive-like state and nitrite level increases (an indirect marker of nitric oxide production). Moreover, EO alone significantly increased TERT mRNA expression, revealing for the first time a potent antiaging action in the brain that suggests neuroprotection against long-term age-related consequences.

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Section: Discussionmentioning

confidence: 69%

Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice

Souza-Monteiro

Arrifano

Queiroz

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…In this section firstly pre-clinical data is described in relation to psychotropic medications and TA and the results are interpreted with respect to depression-like behaviors in murine models. In a recently published study, it was found that depressive phenotype induced by CMS in rats was reversed by desipramine (a tricyclic antidepressant) and this was associated with restored TA as measured by increased TERT expression along with a reduction in oxidative damage to animal liver 65). The study concluded that anti-depressant administration was able to rescue age-related phenotypes in depressed individuals induced by chronic stress.…”

Section: Telomerase Activity In Mood Disordersmentioning

confidence: 93%

“…Preclinical investigations raise the likelihood that brain TA may be relevant to the depression phenotype in mice because of the following observations3,65):…”

Section: Telomerase Activity In Mood Disordersmentioning

confidence: 99%

Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature

Muneer

Minhas

2019

Clin Psychopharmacol Neurosci

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Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric conditions like major depressive disorder, bipolar disorder and schizophrenia may be associated with accelerated cellular aging, indicated by shortened leukocyte telomere length (LTL), which could underlie this connection. Telomere shortening occurs with repeated cell division and is reflective of a cell’s mitotic history. It is also influenced by cumulative exposure to inflammation and oxidative stress as well as the availability of telomerase, the telomere-lengthening enzyme. Precariously short telomeres can cause cells to undergo senescence, apoptosis or genomic instability; shorter LTL correlates with compromised general health and foretells mortality. Important data specify that LTL may be reduced in principal psychiatric illnesses, possibly in proportion to exposure to the ailment. Telomerase, as measured in peripheral blood monocytes, has been less well characterized in psychiatric illnesses, but a role in mood disorder has been suggested by preclinical and clinical studies. In this manuscript, the most recent studies on LTL and telomerase activity in mood disorders are comprehensively reviewed, potential mediators are discussed, and future directions are suggested. An enhanced comprehension of cellular aging in psychiatric illnesses could lead to their re-conceptualizing as systemic ailments with manifestations both inside and outside the brain. At the same time this paradigm shift could identify new treatment targets, helpful in bringing about lasting cures to innumerable sufferers across the globe.

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“…OFT was conducted in a camera obscura (30 cm long×30 cm wide×30 cm high) which was made of black plexiglas and with digital auto photometer to detect the depressive-like response of mice (Xie et al ., 2017). The apparatus was placed in a darkened, and sound attenuated testing room.…”

Section: Methodsmentioning

confidence: 99%

Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment

Xiao

Wang

et al. 2019

Biomol Ther

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Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.

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Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress

Cited by 8 publications

References 40 publications

Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice

Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice

Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature

Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment

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