There are three phases to solve multiple response optimization (MRO) problems. They are experiment design, modelling and optimization. Different committee machines (CMs) are applied for modeling of MRO problem. Two kinds of CM introduced by current authors in recent works. Initial approach includs utilization of all experts in CM and finally sequentilal combinational model (SCM) is created. Current study proposes a combinational approach to filter and select the best experts to create CM which yields optimum combinational model (OCM). Also , there was another modeling with name point approach model (PAM). This study investigated two different features of different SCMs, PAM and OCM in a famous MRO problem with name wire-bonding. This problem was defined in 1997 and then, several researchers solved it in next years. The results show PAM has minimum RMSE but its global desirability is low. Also overall RMSE has a slightly fall from SCMs to OCM , whereas, there is gently rise in global desirability from SCMs to OCM and consequently proposed approach or OCM provides superior results.