Desmoid tumors in neurosurgery: A review of the literature

Vloo, Philippe De; Vlieger, Jan De; Poorten, Vincent Vander; Sciot, Raf; Loon, J. van; Calenbergh, Frank Van

doi:10.1016/j.clineuro.2014.12.007

Cited by 4 publications

(16 citation statements)

References 66 publications

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“…Extra-abdominal desmoid tumors (DTs) are rare tumors of apparent fibroblastic origin with unpredictable clinical behavior. Desmoid-type fibromatosis accounts for less than 3% of all soft tissue tumors and about 0.03% of all neoplasms [ 1 - 3 ], affecting two to four people per million, predominantly women [ 4 - 5 ]. Though histologically benign and slow growing, DTs can be proliferative, aggressive tumors, invading the surrounding areas.…”

Section: Introductionmentioning

confidence: 99%

Extra-abdominal Desmoid Tumor Mimicking Cervical Spine Schwannoma

Goldstein

Hoang

Miller

et al. 2018

Cureus

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Extra-abdominal desmoid tumors (DTs) are rare tumors of apparent fibroblastic origin with unpredictable clinical behavior. Though histologically benign and slow growing, DTs can be proliferative, aggressive tumors, invading the surrounding areas. DTs located extra-abdominally are most commonly found in the extremities or proximal structures like the shoulders, chest wall, and neck. Spinal involvement is very rare. Here, we describe a case where an extra-abdominal DT mimicked a schwannoma in the posterior cervical spine. A 67-year-old female patient presented with acute neck and bilateral shoulder pain. After attempting conservative treatments with no symptomatic relief, a magnetic resonance imaging of the cervical spine was obtained, showing a paraspinal mass in the posterior elements from C2 to C4. The computed tomography guided needle biopsy showed rare spindle cells, suggestive of a spindle cell neoplasm, and complete surgical resection was performed. The pathology report was consistent with fibromatosis, leading to a final diagnosis of the extra-abdominal desmoid. This case demonstrates a rare presentation of an unusual tumor that often manifests with nonspecific symptoms or no symptoms at all.

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Section: Introductionmentioning

confidence: 99%

Extra-abdominal Desmoid Tumor Mimicking Cervical Spine Schwannoma

Goldstein

Hoang

Miller

et al. 2018

Cureus

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“…They have a high incidence of recurrence after surgical resection, with head and neck DTs exhibiting among the highest rate of recurrence and are thus difficult to definitively cure. We have providgrowing, locally invasive, and recur after surgical resection at high rates [2][3][4]. While DTs at all sites commonly recur after surgical excision, recurrence rates with head and neck DTs are much higher.…”

Section: Resultsmentioning

confidence: 99%

“…When recurrence rates were compared in patients with grossly negative surgical margins and grossly positive surgical margins for head, neck, and spine DTs, two studies showed statistical significance (p < 0.05) for lower recurrence rate after gross total resection, and seven showed a trend toward lower recurrence rates in patients with gross total resection. A summary of the recurrence rates following grossly complete resections compared to grossly incomplete excisions in case series with DTs of the head and neck is presented [3,[22][23][24][25][26][27][28][29][30] (Table 1).…”

Section: Literature Reviewmentioning

confidence: 99%

“…While DTs do not spread metastatically, they can invade local tissue and frequently recur after surgical resection [2][3][4]; for this reason they are often categorized with low-grade soft tissue sarcomas [5]. Approximately 2-4 cases of DTs per million people occur each year, and account for 0.03% of all neoplasms [6] and 3% of soft tissue tumors [7].…”

Section: Introductionmentioning

confidence: 99%

“…We focus on the importance of instrumentation due to aggressive resection of posterior paraspinal musculature Although most cases of DTs are sporadic [3], there is a distinct association with Familial Adenomatous Polyposis (FAP, Gardner's syndrome) and other Adenomatous Polyposis Coli (APC) gene mutations [10]. In fact, patients with FAP have DTs at approximately 850 times the rate of the general population, most commonly located in the small intestine or mesentery [11].…”

Section: Introductionmentioning

confidence: 99%

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Aggressive Resection of Cervical Desmoid Tumor Invading the Paraspinal Muscles without Recurrence at Eight Year Followup: A Case Report and Review of the Literature

Eichberg¹,

Urakov²,

Vanni³

2017

Clin Med Rev Case Rep

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Objective: To provide an overview of head, neck, and spine Desmoid Tumor (DT), to describe the case of a patient who underwent aggressive surgical resection of a large invasive cervical DT, and to analyze the DT literature. We discuss the importance of aggressive surgical margins in decreasing recurrence risk in head, neck, and spine DTs. Methods:A twenty-three-year-old female patient with history of a left cervical neurofibroma resection presented two years later with neck mass regrowth. The mass was aggressively resected, and occiput to T1 fusion was performed. Additionally, the head, neck, and spine DT literature was reviewed regarding surgical margin status and recurrence rate. A "N-1" Chi-squared test was used to compare proportions, between percentage of patients that experienced recurrence after gross total resection, and percentage of patients that experienced recurrence after subtotal resection, to determine statistical significance (p < 0.05).Results: Histologically, the lesion was shown to be a DT, with posterior paracervical spinal musculature invasion. The surgery was well tolerated with no complications. At eight years postoperative followup, the patient is doing well with no tumor recurrence. Nine studies were identified describing surgical margin status and recurrence rate of head, neck, and spine DT. When recurrence rates were compared in patients with grossly negative surgical margins and grossly positive surgical margins for head, neck, and spine DTs, two studies showed statistical significance (p < 0.05) for lower recurrence rate after gross total resection, and seven showed a trend toward lower recurrence rates in patients with gross total resection. Conclusion:DTs are difficult clinical entities to cure due to high recurrence rate after resection. Consistent with previous studies indicating that aggressive surgical margins are associated with a decreased risk of recurrence, we present a case report of a female patient who underwent aggressive resection of a large DT and remains tumor-free after eight years. Thus, we recommend aggressive surgical resection of head, neck, and spine DTs to minimize recurrence risk.

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A Sporadic Pediatric Case of Huge Intracranial Supratentorial Desmoid-type Fibromatosis

Imai

Ohe

Ozeki

et al. 2021

NMC Case Report Journal

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Desmoid-type fibromatosis (DTF) is a rare locally aggressive soft tissue neoplasm without metastatic potential. Here, we report a very rare sporadic case of an intracranial supratentorial extradural DTF measuring 82 mm in a 1-year-old girl, that recurred twice following surgery over the course of 16 months, requiring two other surgeries. In three surgeries, we resected a huge tumor with the dura which was thought to be tumor origin and removed this tumor infiltrated the frontal skull base by drilling widely. Furthermore, we treated the tumor invading the bone flap using liquid nitrogen for 20 minutes, and subsequently used it to perform a cranioplasty. This tumor has not recurred for past 8 months. DTF invading the skull base is prone to recurrence, and liquid nitrogen treatment is considered to be effective in pediatric patients, who need cranioplasty with tumor-infiltrating autologous bone flaps.

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Desmoid tumors in neurosurgery: A review of the literature

Cited by 4 publications

References 66 publications

Extra-abdominal Desmoid Tumor Mimicking Cervical Spine Schwannoma

Extra-abdominal Desmoid Tumor Mimicking Cervical Spine Schwannoma

Aggressive Resection of Cervical Desmoid Tumor Invading the Paraspinal Muscles without Recurrence at Eight Year Followup: A Case Report and Review of the Literature

A Sporadic Pediatric Case of Huge Intracranial Supratentorial Desmoid-type Fibromatosis

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