Desmoplastic Fibroblastoma: A Light and Ultrastructural Description of Two Cases

Alberghini, Marco; Pasquinelli, Gianandrea; Zanella, Licciana; Bacchini, Patrizia; Bertoni, Franco

doi:10.1080/01913120490475761

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…Th2 cytokines have been linked to diminished resistance to mycobacterial infection (12–18, 45) so we assessed the effect of SIV infection on IL-4 and IL-10 expression in the macaques. IL-10 + T cells were present at low frequencies on a constitutive basis over the course of infection, but their frequency did not increase above baseline levels in response to stimulation with CFP or Gag/Pol Ags (data not shown).…”

Section: Resultsmentioning

confidence: 99%

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

Mattila

Diedrich

Lin

et al. 2011

The Journal of Immunology

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Understanding the early immunologic events accompanying reactivated tuberculosis (TB) in HIV-infected individuals may yield insight into causes of reactivation and improve treatment modalities. We used the cynomolgus macaque (Macaca fascicularis) model of HIV–Mycobacterium tuberculosis coinfection to investigate the dynamics of multifunctional T cell responses and granuloma T cell phenotypes in reactivated TB. CD4+ and CD8+ T cells expressing Th1 cytokines (IFN-γ, IL-2, TNF) and Th2 cytokines (IL-4 and IL-10) were followed from latent M. tuberculosis infection to reactivation after coinfection with a pathogenic SIV. Coinfected animals experienced increased Th1 cytokine responses to M. tuberculosis Ags above the latent-response baseline 3–5 wk post-SIV infection that corresponded with peak plasma viremia. Th2 cytokine expression was not Ag specific, but strong, transient IL-4 expression was noted 4–7 wk post-SIV infection. Animals reactivating <17 wk post-SIV infection had significantly more multifunctional CD4+ T cells 3–5 wk post-SIV infection and more Th2-polarized and fewer Th0-, Th1-polarized CD8+ T cells during weeks 1–10 post-SIV infection than animals reactivating >26 wk post-SIV infection. Granuloma T cells included Th0-, Th1-, and Th2-polarized phenotypes but were particularly rich in cytolytic (CD107+) T cells. When combined with the changes in peripheral blood T cells, these factors indicate that events during acute HIV infection are likely to include distortions in proinflammatory and anti-inflammatory T cell responses within the granuloma that have significant effects on reactivation of latent TB. Moreover, it appears that mycobacteria-specific multifunctional T cells are better correlates of Ag load (i.e., disease status) than of protection.

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Section: Resultsmentioning

confidence: 99%

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

Mattila

Diedrich

Lin

et al. 2011

The Journal of Immunology

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“…On electron microscopy, Nielson and colleages demonstrated that the cells have ultrastructural features characteristic of fibroblasts and myofibroblasts . In addition, Alberghini and colleages demonstrated the presence of fibronexus junctions on electron microscopy, markers of myofibroblastic differentiation …”

Section: Discussionmentioning

confidence: 98%

Dermal desmoplastic fibroblastoma presenting as a large sacral mass

Lin

2015

Aust J Dermatology

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Desmoplastic fibroblastoma (collagenous fibroma) is a rare and recently recognised benign tumour. Most desmoplastic fibroblastomas arise in the subcutaneous tissue or skeletal muscle. Involvement of the dermis is extremely rare. We describe an unusual case of dermal desmoplastic fibroblastoma presenting as a large sacral mass in a 16-year-old male. An awareness of this entity is necessary to avoid confusion with other benign and malignant soft tissue neoplasms.

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“…They usually infiltrate the underlying muscle or bone [2,3,4,5,11,14,15,16,17]. Their localizations were scapular [3], infrascapular region [2], abdominal wall [5], vertebra [11], lower intraabdomen [2,14], trapezius muscle [15], supraclavicular fossa [16], pectoralis minor muscle [4], and back [17]. Moreover, there are some cases of uncommon CF locations, in the oral mucosa, tongue and orbital area [18,19,20,21,22].…”

Section: Discussionmentioning

confidence: 99%

A Case of Superficial Collagenous Fibroma and Review of the Literature

2014

J Turk Acad Dermatol

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Observation: Collagenous fibroma (desmoplastic fibroblastoma) is a rare and benign soft tisue tumor, affecting mainly men in their 5th through 7th decades. These lesions are well-circumscribed, slow-growing, firm, and painless masses of 1-15 cm diameter with oval, fusiform or disc shape. The tumor consists of hypocellular proliferation of the spindle to stellate-shaped mesenchymal cells, embedded in a hyalinized collagenous stroma. Up till now, approximately 120 cases have been reported in the literature. In the English dermatologic literature, only 5 cases have been discussed before. In this report, a 65 year old male patient with superficial collagenous fibroma presenting with an unusual clinical appearance over the left breast has been described. The clinicopathological features are also discussed in comparing with other cases reported in the literature. Figure 1. Linear papulonodular lesion over the uppermedial part of the left breast.

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Desmoplastic Fibroblastoma: A Light and Ultrastructural Description of Two Cases

Cited by 9 publications

References 11 publications

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

Dermal desmoplastic fibroblastoma presenting as a large sacral mass

A Case of Superficial Collagenous Fibroma and Review of the Literature

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