Desmoplastic malignant melanoma of the uterine cervix: a rare primary malignancy in the uterus mimicking a sarcoma

Ishikura, Hiroshi; Kojo, Tatsuro; Ichimura, Hideo; Yoshiki, Takashi

doi:10.1046/j.1365-2559.1998.0415h.x

Cited by 22 publications

(11 citation statements)

References 6 publications

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“…A careful differential diagnosis is necessary to distinguish blue nevi from their malignant counterpart, desmoplastic melanoma, which can develop as a primary uterine cervical tumor [15]. Immunohistochemically, whereas blue nevi are positive for most of the representative melanocytic markers including S100 protein, HMB45 and MART-1, desmoplastic melanomas are negative for the latter two markers [13].…”

Section: Discussionmentioning

confidence: 99%

Blue nevus presenting as an endocervical polyp

Masuko¹,

Kato²,

Iwai³

2016

pjp

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We report herein a case of blue nevus of the uterine cervix presenting as an endocervical polyp. A 58-year-old Japanese female was presented with an endocervical polyp. The polyp was promptly excised, and histological examination revealed distribution of many melanin-loaded spindle-shaped cells in its stromal portion. Immunohistochemically, the cells were positive for S100 protein, SOX10, HMB45, and MART-1. Based on the characteristic cellular morphology and immunohistochemical findings, the lesion was diagnosed as a blue nevus, and malignant melanoma was denied. Endocervical blue nevi are relatively rare, and there are some discordance among previous publications about immunoreactivity against HMB45 and MART-1.

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Section: Discussionmentioning

confidence: 99%

Blue nevus presenting as an endocervical polyp

Masuko¹,

Kato²,

Iwai³

2016

pjp

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“…An occasional series or case reports have been documenting amelanotic melanoma originating exclusively in the vulva and uterine cervix. [2][3][4][5][6][7][8][9] Ragnarsson-Olding reported that 27% of all vulvar melanomas are amelanotic type, however the incidence of cervical amelanotic melanoma is not yet known.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9] Moreover, delayed diagnosis and advanced stage can further increase the difficulty in management. For amelanotic melanoma in the cervix, most authors have recommended radical hysterectomy and if necessary, to obtain clean surgical margins of at least 2 cm.…”

Section: 10mentioning

confidence: 99%

“…The absence or rarity of melanin granules in amelanotic melanomas can lead to their misdiagnoses as carcinomas, sarcomas or lymphoma. [2][3][4][5][6][7][8][9] In this context, ancillary immunohistochemistry is of value and the use of vimentin, S-100 and HMB-45 monoclonal antibody is reported to vastly improve the accuracy of diagnosing malignant melanomas. [3][4][5][6][7][8][9] We present a rare case of primary amelanotic melanoma of the cervix, which was initially suspected to be a poorly differentiated malignant tumor with a wide differential diagnosis of carcinoma, sarcoma, lymphoma and amelanotic melanoma but was subsequently correctly diagnosed by immunohistochemistry.…”

Section: Introductionmentioning

confidence: 99%

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Primary amelanotic melanoma of the cervix: case report with review of literature

Duggal

Srinivasan

2010

J Gynecol Oncol

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Primary malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. It may be misdiagnosed especially when amelanotic, in which case immunohistochemistry is useful in reaching the diagnosis. We present one such case of a 65-year-old postmenopausal female patient presenting with bleeding per vaginum. Speculum examination revealed an ulcero-proliferative growth involving the cervix. On histopathological examination it was originally suspected to be a poorly differentiated carcinoma or a non-epithelial malignant tumor, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and S-100 protein.

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“…Amelanotic forms of malignant melanoma may require differentiation from the other common cervical malignancies. Rare tumours like cervical malignant peripheral nerve sheath tumour and sarcoma uterus have also been reported to resemble its amelanotic form 2. Common blue naevus of the uterine cervix can also be considered to be one of the differentials 3.…”

Section: Differential Diagnosismentioning

confidence: 99%

Primary malignant melanoma of uterine cervix with probable origin from benign cervical melanosis

2013

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We report a case of primary malignant melanoma of cervix which is a rare malignancy with only around 60 cases being reported. This patient presented with bleeding per vaginum. A large exophytic growth from cervix with black discolouration was seen. International Federation of Gynaecology and Obsterics (FIGO) staging was stage IIa. Histoimmunocytology confirmed the diagnosis of malignant melanoma of cervix. S-100 and HMB-45 are reliable markers for cervical melanomas. We attempted Wertheim's hysterectomy; but, due to extensive disease, paravescical and pararectal fossae could not be dissected and we had to perform type I hysterectomy. The patient was started on adjuvant chemotherapy with dacarbazine. Despite counselling, she refused a complete course of chemotherapy and died after 6 months. Radical surgery, chemotherapy and immunotherapy are the therapeutic modalities used. In bulky disease, neoadjuvant chemotherapy should be considered to reduce the tumour bulk and facilitate required surgery. Prognosis is poor and unpredictable.

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Desmoplastic malignant melanoma of the uterine cervix: a rare primary malignancy in the uterus mimicking a sarcoma

Cited by 22 publications

References 6 publications

Blue nevus presenting as an endocervical polyp

Blue nevus presenting as an endocervical polyp

Primary amelanotic melanoma of the cervix: case report with review of literature

Primary malignant melanoma of uterine cervix with probable origin from benign cervical melanosis

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