Desmosomal Cadherins in Basal Cell Carcinomas

Discordant expression of desmoglein 2 and 3 at the mRNA and protein levels in nodular and superficial basal cell carcinoma revealed by immunohistochemistry and fluorescentin situhybridization

“…It has even been suggested that BCC should not be treated as a single condition . On the other hand, many BCCs show a mixed histological pattern . Mosaicism may be an effect of a new mutation, resulting in undifferentiation of the new neoplastic cell, or alternatively, possibly resulting in protein alteration, thus making the tumour differentiated.…”

“…Skin cancer usually occurs in old age and some studies have indicated that the Dsg expression of increases with skin ageing . Moreover, subsequent reports indicated greater cell proliferation activity in BCC than suggested by the clinically apparent slow growth of the tumour, and proposed a specific role of Dsgs in proliferation/differentiation in BCC . Thus, the functional importance of Dsgs in the adhesion of carcinoma cells and during metastasis makes them a useful tool for evaluation of the biological behaviour of BCC .…”

“…6,7 Thus, the functional importance of Dsgs in the adhesion of carcinoma cells and during metastasis makes them a useful tool for evaluation of the biological behaviour of BCC. 7 It has been hypothesized that the level of Dsg expression in tumour cells may be associated with the invasive ability of BCC. 8 The mechanism by which Dsgs affect tumourigenesis has not been fully determined, and requires further investigation.…”

“…Moreover, subsequent reports indicated greater cell proliferation activity in BCC than suggested by the clinically apparent slow growth of the tumour, and proposed a specific role of Dsgs in proliferation/differentiation in BCC . Thus, the functional importance of Dsgs in the adhesion of carcinoma cells and during metastasis makes them a useful tool for evaluation of the biological behaviour of BCC . It has been hypothesized that the level of Dsg expression in tumour cells may be associated with the invasive ability of BCC .…”

Reviews Basal cell carcinoma – diagnosis

“…The immunohistochemical profile can be used to demonstrate the expression of cytokeratins that is typical for the bulge region of a hair follicle [ 31 ]. When compared with normal epidermis there is overexpression of desmoglein 2 and lower expression of desmoglein 3 in the BCC nests [ 36 ]. Tumors express BerEP4, bcl-2, CD10, SOX9, p53 and actin in more aggressive cases [ 31 ] ( Table 2 ).…”