Desorption–ionization on silicon mass spectrometry: an application in forensics

Thomas, John J.; Shen, Zhouxin; Blackledge, Robert D.; Siuzdak, Gary

doi:10.1016/s0003-2670(01)01107-2

Cited by 88 publications

(68 citation statements)

References 15 publications

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“…Because no matrix is present, the chemical noise is minimal, allowing the analysis of small molecules present in low concentrations. 16,18 In addition, the sample preparation is minimal, and samples can be stored on DIOS chips for later analysis. DIOS-MS has been utilized in the study of peptides, 19 proteins 20 and small drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Pihlainen

Grigoras²,

Franssila³

et al. 2005

J. Mass Spectrom.

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The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) and matrix-assisted laser desorption ionization mass spectrometry (AP-MALDI-MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP-DIOS-MS/MS and AP-MALDI-MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP-DIOS-MS/MS were 1-3 pmol, indicating excellent sensitivity of the method. The LODs with AP-MALDI-MS/MS were about 5-10 times higher.

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Section: Introductionmentioning

confidence: 99%

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Pihlainen

Grigoras²,

Franssila³

et al. 2005

J. Mass Spectrom.

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“…Consequently, the most illustrative mass spectral data of nonoxynol-9 to date have been obtained by LC-MS and desorption chemical ionization MS, which yielded chromatograms in which the individual isomeric components were not resolved [4,5]. These techniques employ softer ionization methods that produce primarily molecular ions and simpler spectra with little to no fragmentation when compared with EI-based methods [6,[10][11][12][13]. The incorporation of a simple sonication step during the extraction was designed to disrupt micelles to better solubilize the material.…”

Section: Resultsmentioning

confidence: 99%

“…Significant effort has gone into developing advanced MS techniques for analysis of lubricants, in particular electrospray ionization-MS along with liquid chromatography-MS, matrix-assisted laser desorption ionization (MALDI)-MS, and other desorption techniques [4,6,[10][11][12][13]. However, these advanced methods and instrumentation are not widely utilized in crime laboratories.…”

mentioning

confidence: 99%

Detection of the Spermicide Nonoxynol-9 Via GC-MS

Musah

Vuong

Henck

et al. 2012

J. Am. Soc. Mass Spectrom.

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The spermicide nonoxynol-9 is actually a complex mixture of dozens of closely related amphiphilic compounds, and the chemical properties of this assortment significantly hamper its characterization by GC-MS. The inability to perform routine GC-MS testing on nonoxynol-9 has limited its evidentiary value in forensic casework, which relies heavily on this technique for analysis. A disturbing trend in sexual assault is the use of condoms by assailants, to avoid leaving behind DNA evidence that can connect a perpetrator to a victim. This observation necessitates the development of alternative methods for the analysis of trace evidence that can show causal links between a victim and a suspect. Detection of lubricants associated with sexual assault is one such way to establish this connection. The development of GC-MS methods that permit facile detection of both nonoxynol-9 alone and nonoxynol-9 extracted from other complex matrices that have potential as trace evidence in sexual assault is reported. A detection limit of 2.14 μg of nonoxynol-9 is demonstrated, and a detailed mass spectral profile that elaborates on what is known of its structure is provided.

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“…However, this technique is not conducive to small molecule analysis due to the matrix and its fragment peaks obscuring the low mass range typically below 700 Da. 4 Surface-assisted laser desorption ionisation mass spectrometry (SALDI-MS) is an adaption of MALDI-MS and employs nanostructured surfaces with UV absorbing properties to alleviate the need for the matrix. In 1999, Suizdak et al developed one of the first representations of SALDI which was termed desorption ionisation on porous silicon (DIOS).…”

Section: Matrix-assisted Laser Desorption Ionisation Mass Spectrometrmentioning

confidence: 99%

Rapid detection of nicotine from breath using desorption ionisation on porous silicon

2017

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Desorption–ionization on silicon mass spectrometry: an application in forensics

Cited by 88 publications

References 15 publications

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Detection of the Spermicide Nonoxynol-9 Via GC-MS

Rapid detection of nicotine from breath using desorption ionisation on porous silicon

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