Desperately seeking grey matter volume changes in sleep apnea: A methodological review of magnetic resonance brain voxel-based morphometry studies

Celle, Sébastien; Delon‐Martin, Chantal; Roche, Frédéric; Barthélémy, Jean‐Claude; Pépin, Jean‐Louis; Dojat, Michel

doi:10.1016/j.smrv.2015.03.001

Cited by 48 publications

(52 citation statements)

References 82 publications

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“…It has been suggested that the diverse and often conflicting findings regarding brain structure and function in a variety of disorders may be ameliorated by a more finely tuned understanding of which structures in networks are most implicated (Celle et al, 2015, Eickhoff and Bzdok, 2013). In this vein, in our study, we have undertaken to gain greater understanding of core features of regional volume and activity alteration in patients with OSA across the published literature by using the ALE meta-analysis of currently available functional and structural imaging studies.…”

Section: Discussionmentioning

confidence: 99%

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Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis

Tahmasian

Rosenzweig

Eickhoff

et al. 2016

Neuroscience & Biobehavioral Reviews

109

102

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HighlightsThe right basolateral amygdala, the hippocampus and the right insular cortex are important nodes in obstructive sleep apnea (OSA).Functional characterization of these regions suggested associated dysfunction of emotional, sensory, and limbic processes in OSA.Connectivity analysis demonstrated that these regions are part of a joint network comprising the anterior insula, posterior-medial frontal cortex and thalamus.

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Section: Discussionmentioning

confidence: 99%

“…Structural and functional MRI imaging studies, however, often point to diverse results in OSA (Celle et al, 2015, Morrell and Glasser, 2011). The variability of the findings has been suggested to be due to relatively small sample sizes, with heterogeneous patient groups that differed in several key respects (e.g.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis

Tahmasian

Rosenzweig

Eickhoff

et al. 2016

Neuroscience & Biobehavioral Reviews

109

102

View full text Add to dashboard Cite

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“…However, the close to 200 subjects included here would greatly minimized the influence of any unidentified OSA subjects. Furthermore, using such large cohort is a recommendation based on a recent critical review of VBM studies in adult OSA29. Of note, different scanners and scanning parameters were used to acquire the brain scans.…”

Section: Discussionmentioning

confidence: 99%

“…We used a large control cohort, since increasing cohort size is one approach to improve reliability of VBM analyses in OSA29. Full details of recruitment and scanning protocols are available from the project website, including confirmation that consent and assent was obtain as appropriate for the age of the subjects, and that procedures were approved by applicable institutional review boards.…”

Section: Methodsmentioning

confidence: 99%

Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea

Philby

Macey

Richard

et al. 2017

Sci Rep

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Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA children (8 male, 8.1 ± 2.2 years, AHI:11.1 ± 5.9 events/hr), and 200 control subjects (84 male, 8.2 ± 2.0 years), 191 of whom were from the NIH-Pediatric MRI database. High resolution T1-weighted whole-brain images were assessed between groups with voxel-based morphometry, using ANCOVA (covariates, age and gender; family-wise error correction, P < 0.01). Significant grey matter volume reductions appeared in OSA throughout areas of the superior frontal and prefrontal, and superior and lateral parietal cortices. Other affected sites included the brainstem, ventral medial prefrontal cortex, and superior temporal lobe, mostly on the left side. Thus, pediatric OSA subjects show extensive regionally-demarcated grey matter volume reductions in areas that control cognition and mood functions, even if such losses are apparently independent of cognitive deficits. Since OSA disease duration in our subjects is unknown, these findings may result from either delayed neuronal development, neuronal damaging processes, or a combination thereof, and could either reflect neuronal atrophy or reductions in cellular volume (neurons and glia).

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“…Les résultats des études VBM sont néanmoins contradictoires et posent de nombreuses questions méthodologiques [19]. Par ailleurs, même si un certain nombre d'arguments, issus notamment des études effectuées chez l'animal, soutiennent l'hypothèse que ces changements soient une conséquence du SAOS, les techniques de neuro-imagerie ne permettent pas de déterminer leur origine temporelle, autrement dit, si ces lésions ne précèdent pas le début du SAOS.…”

Section: Résumé Et Conclusionunclassified