Destruction of the Gastric Mucosal Barrier by Detergents and Urea

Davenport, Horace W.

doi:10.1016/s0016-5085(68)80001-0

Cited by 399 publications

(81 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…* Significantly different from the control group (p < 0.01). The gastric wall mucus is thought to play an important role as a defensive factor against gastrointestinal damage (Davenport, 1968). The determined gastric wall mucus was used as an indicator for gastric mucus secretion (Lukie and Forstner, 1972).…”

Section: Resultsmentioning

confidence: 99%

Anti-gastric ulcer effect of Kaempferia parviflora

Rujjanawate

Kanjanapothi

Amornlerdpison

et al. 2005

Journal of Ethnopharmacology

142

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Anti-gastric ulcer effect of Kaempferia parviflora

Rujjanawate

Kanjanapothi

Amornlerdpison

et al. 2005

Journal of Ethnopharmacology

142

View full text Add to dashboard Cite

“…There seem to be two possible candidates for this factor: back-diffusion of H+ in exchange for Na+ (Davenport, 1968) and reflux through the pylorus of alkaline duodenal contents (Du Plessis, 1965). Backdiffusion of H+ through the rnucosa of the stomach wall could explain the lowered H" and raised Na' concentration, but less well the lowered C1-and certainly not the higher K" concentration in the acid component of gastric ulcer patients relative to controls.…”

Section: Control Group Correction Of the Regression Equations Ofmentioning

confidence: 99%

Pyloric Reflux: A Modification of the Two-Component Hypothesis of Gastric Secretion

Hobsley

1974

Clinical Science

View full text Add to dashboard Cite

S U M M A R Y1. Gastric juice was obtained during continuous maximal stimulation with histamine diphosphate, 0.13 pmol h-' kg-l (0.04 mg h-' kg-l) intravenously, in thirtyfour control subjects, twenty-eight patients with duodenal ulcer, and eighteen with gastric ulcer. After correction for pyloric losses, the average rate of outputs of water, and of H', Na', K+ and C1-were determined.2. The results were analysed in terms of the two-component theory of gastric secretion. The acid components in control subjects and duodenal ulcer patients were similar in composition, but that in gastric ulcer patients was by comparison hypotonic and less acid and contained more sodium ions.3. Calculation of the volume and composition of the alkaline component gave reasonable results in the control and duodenal ulcer groups, but impossible results in the gastric ulcer group. The gastric juice of gastric ulcer patients could not be described in terms of classical two-component theory. 4.In all three groups, volume correlated quite well with Cl-output alone, less well with H' output, poorly with K' output, and not at all with Na' output. However, when volume was expressed as a function of the outputs of C1-and one other ion, K+ performed poorly, H' well, and Na' best of all.5. Some features suggest that reflux of alkaline liquid from the duodenum is a better explanation of these results than back-diffusion of H' in exchange for Na' between the lumen and wall of the stomach.6. If the refluxing liquid is assumed to be isotonic, its composition can be calculated. Hence, the volume of reflux in a sample of gastric juice can be deduced. Reflux appeared to be more important in the gastric ulcer patients than in the other two groups.

show abstract

“…When gastric mucosal barriers are disrupted by ulcerogenics, such as ethanol, aspirin or bile salts, the intraluminal free acid may back diffuse through damaged mucosal barriers and consequently leads to histamine release and exacerbation of gastric hemorrhagic ulcer. This back-diffusion of gastric acid is recognized as a sensitive index for mucosal integrity (Davenport and Chavre, 1968;Hung and Neu, 1997).…”

Section: Introductionmentioning

confidence: 99%