Destructive Fibrosarcoma of the Maxillary Sinus

Ekinci, Adnan; Karataş, Duran; Yetiş, Abdurrahman; Erenler, Behice Hande; Özcan, Müge

doi:10.1097/scs.0000000000004173

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…While other studies recommend surgery as the mainstay of treatment, with radiotherapy for more malignant tumors, as reflected by the results of this study [23,26]. Due to the frequent local recurrent nature of fibrosarcomas, some studies recommended a wide local excision with an extensive surgical border [1,14,22]. It is also worth mentioning the use of endoscopic surgery as opposed to open surgeries.…”

Section: Treatment and Mortalitymentioning

confidence: 69%

“…Fibrosarcomas are rare, malignant neoplasms of mesenchymal origin that comprise 7-10% of all head and neck sarcomas [1]. Fibrosarcoma appears to be sporadic, but cases of fibrosarcoma secondary to radiation of nasopharyngeal carcinomas have been reported [2].…”

Section: Introductionmentioning

confidence: 99%

“…As with other nasal cavity and paranasal sinus pathologies, PNFS often presents with unilateral nasal obstruction and epistaxis, sometimes being mistaken as a papilloma [1]. Previous reports have found associations with age and gender but reports vary [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…PNFS is associated with a high risk of local recurrence and a low risk of distant metastasis [3]. Due to this association, PNFS are often treated with local excision with large margins with or without radiotherapy [1]. The extent of resection is also dependent upon the presence or absence of bone invasion.…”

Section: Introductionmentioning

confidence: 99%

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Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Bughrara¹,

Almsaddi²,

John³

et al. 2022

Cureus

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Fibrosarcomas are rare, malignant neoplasms of mesenchymal origin. Fibrosarcomas appear to be sporadic, but cases of fibrosarcomas secondary to radiation of nasopharyngeal carcinomas have been reported. Paranasal sinus fibrosarcomas (PNFS) are even rarer with few cases being reported since the 1950s. There have been several retrospective cohort studies examining PNFS; however, to our knowledge, no comprehensive review exists. This review aims to summarize the findings of all published cases of PNFS from the 1950s to the 2020s. We hope that a comprehensive review will assist in accurate and early diagnoses of PNFS, and help guide treatment as early treatment is associated with a favorable prognosis. This systematic review reports results following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted on PubMed, Embase, and Cochrane Library. Studies were screened using established inclusion/exclusion criteria. A total of 26 studies were included for data extraction, and relevant data were collected and analyzed. In our study, the most common study type was case reports (n = 19). The most common presentation for PNFS included male gender (n = 17) with maxillary sinus (n = 57) involvement. Patients commonly presented with complaints of nasal obstruction (n = 15), epistaxis (n = 11), and facial fullness/pain (n = 9). Surgical resection was the mainstay treatment, with the use of chemotherapy or radiation depending on surgical margins and resectability. The diagnosis was commonly made with histological analysis. This review of the literature provides a summary and reference of important presenting factors, elements of diagnosis, and treatment options regarding PNFS to help bring awareness and guide the treatment of such a rare disease. Moving forward, there is a greater need for larger standardized studies that can further complement our findings, as well as more consistent reporting of cases.

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Section: Treatment and Mortalitymentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Bughrara¹,

Almsaddi²,

John³

et al. 2022

Cureus

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“…Sinonasal fibrosarcoma is a rare malignant tumor, with only 1% of fibrosarcomas occurring in the head and neck region, whereas the majority are found at the extremities (11). Final diagnosis and staging are based on histopathology, immunohistochemistry examination and on the imaging evaluation (12).…”

Section: Discussionmentioning

confidence: 99%

Reconstructive challenges of sinonasal tumors: A case report

Palade

Hainăroşie²,

Perţea

et al. 2022

Exp Ther Med

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Sinonasal tumors are an uncommon pathological entity and applying the optimal treatment may represent a challenge, even for experienced physicians. A various number of techniques and materials may be used in the reconstruction of craniofacial defects following surgery for extensive sinonasal cancer. The aim of the present study was to present the case of a 33-year-old male patient diagnosed with a large sinonasal tumor and discuss the challenges faced while selecting the most suitable rehabilitation technique. In the present case, it was decided that the optimal solution was to use a craniofacial prosthesis in order to cover the entire defect, as well as a temporoparietal flap. In summary, reconstructive interventions must always be adapted to each individual patient and a multimodal approach may lead to a highly satisfactory outcome, for both the patient and the surgical team. All the reconstructive solutions available must always be kept in mind and adapted to the individual requirements of each case, taking into consideration both the extent of the tumor and the comorbidities of the patient, as there is no one solution that is considered as optimal for all patients.

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Definitive Radiation Therapy Versus Postoperative Radiation Therapy for Patients With Maxillary Sinus Cancer Invading the Upper Jaw

Wang¹,

Ren²,

Wu³

et al. 2019

Journal of Craniofacial Surgery

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Maxillectomy following radiation therapy has the strongest local control over maxillary sinus cancer. However, in the advanced stage, complete resection is difficult with adequate margin and has the risk of functional disabilities after surgeries. The objective of the study was to determine the optimal treatment strategy for patients with maxillary sinus cancer invades the upper jaw. A total of 998 histologically confirmed maxillary sinus cancer invades the upper jaw patients were subjected to simple randomization. Patients were subjected to maxillectomy and received 150 mg/m2/wk intra-arterial cisplatin for 4 weeks followed by radiotherapy (PR group, n = 499) or received the same chemotherapy and definitive radiotherapy only (DR group, n = 499). Disease status, overall survival, progression-free survival, and treatment-emergent adverse effects were evaluated in the follow-up period of 5 years. At the end of 5 years of follow-up, both the treatments had the same overall survival (P = 0.066). Demographic characters were independent parameters for the overall survival (P ≥ 0.05 for all). Postoperative radiotherapy had a higher progression-free survival than definitive radiotherapy (P = 0.018). Maxillectomy was useful in the reduction of the evidence of local recurrence of cancer (P = 0.027). Dysphagia, palate fistula, incomprehensible voice, and trismus were reported as treatment-emergent effects in the PR group. Definitive radiation therapy is recommended in maxillary sinus cancer that invades the upper jaw (Level of Evidence: I; research registry 4571 dated November 14, 2012).

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Destructive Fibrosarcoma of the Maxillary Sinus

Cited by 3 publications

References 9 publications

Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Reconstructive challenges of sinonasal tumors: A case report

Definitive Radiation Therapy Versus Postoperative Radiation Therapy for Patients With Maxillary Sinus Cancer Invading the Upper Jaw

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