Detailed nomenclature for dendritic molecules

Friedhofen, Jörg; Vögtle, Fritz

doi:10.1039/b513437b

Cited by 22 publications

(8 citation statements)

References 12 publications

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“…Other two nomenclatures for dendrimeric structures are the Newkome-nomenclature [64] and cascadane [65]. Both of these nomenclatures are capable of representing the hyper-branched nature of dendrimers.…”

Section: Molecular Modeling Of Dendrimersmentioning

confidence: 99%

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Molecular Modeling to Study Dendrimers for Biomedical Applications

et al. 2014

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Molecular modeling techniques provide a powerful tool to study the properties of molecules and their interactions at the molecular level. The use of computational techniques to predict interaction patterns and molecular properties can inform the design of drug delivery systems and therapeutic agents. Dendrimers are hyperbranched macromolecular structures that comprise repetitive building blocks and have defined architecture and functionality. Their unique structural features can be exploited to design novel carriers for both therapeutic and diagnostic agents. Many studies have been performed to iteratively optimise the properties of dendrimers in solution as well as their interaction with drugs, nucleic acids, proteins and lipid membranes. Key features including dendrimer size and surface have been revealed that can be modified to increase their performance as drug carriers. Computational studies have supported experimental work by providing valuable insights about dendrimer structure and possible molecular interactions at the molecular level. The progress in computational simulation techniques and models provides a basis to improve our ability to better predict and understand the biological activities and interactions of dendrimers. This review will focus on the use of molecular modeling tools for the study and design of dendrimers, with particular emphasis on the

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Section: Molecular Modeling Of Dendrimersmentioning

confidence: 99%

“…Both of these nomenclatures are capable of representing the hyper-branched nature of dendrimers. Both systems make use of the repetitive units that constitute dendrimers to simplify their notation [64,65]. However, as the dendrimers increase in size, the notation becomes complex and difficult to interpret.…”

Section: Molecular Modeling Of Dendrimersmentioning

confidence: 99%

Molecular Modeling to Study Dendrimers for Biomedical Applications

et al. 2014

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“…Dendrimers, or cascade molecules, are three-dimensional polymeric macromolecules, with tree-like branches extending outwards from a multifunctional core. [223][224][225][226] Typically, their structure is interpreted as a sequence of layers (or generations), 227 with three components being distinguished in an n-generations dendrimer: the core (or root, generation 0), branching units (branched branches, generations 1 to n À 1) and functional units (the last layer of branches, generation n). In solution, dendrimers usually take a globular structure, with functional units constituting a polyvalent outer surface.…”

Section: Dendritic Peptidesmentioning

confidence: 99%

“…When several types of dendrons are present in the same molecule, the dendrimer is called ''cascadane''. 226 The first materials combining peptides and dendrimers were peptide bond-containing dendrimers (''peptide dendrimers''). They have been extensively studied as drug and DNA delivery agents, in a wide range of biomedical applications, work that has been thoroughly reviewed before.…”

Section: Dendritic Peptidesmentioning

confidence: 99%

Peptide-based solids: porosity and zeolitic behavior

2012

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Among the greatest challenges in the field of microporous solids is the development of ''smart'' materials, displaying environment-triggered property tuning. These could be used both in traditional and new applications of microporous materials. In this context, supramolecular peptide-based solids have recently emerged as interesting alternatives to standard microporous solids, such as zeolites and carbon molecular sieves. They possess framework and conformational flexibility, are kinetically stable and reasonably thermally resistant. Important properties such as pore size and inner wall chemistry can be controlled through appropriate chemical modification of the peptide molecules. Peptide-based porous solids have permanent microporosity, often with molecularly sized cavities created by removal of co-crystallised solvent. Some have already been successfully tested as adsorbents and permselective materials, confirming their potential. This review covers the identification, synthesis, characterization techniques and properties of peptide-based microporous solids, discussing their most unique functionalities.

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“…The first was published by Newkome et al (the Newkome nomenclature), 25 and later refined by Friedhofen and Vo¨gtle (the Cascadane nomenclature). 26 A simpler notation system (fractal notation) has been separately devised by Mendenhall, 27 but was intended for use with dendrimers containing homogeneous or nearly homogeneous layers.…”

Section: Introductionmentioning

confidence: 99%