Detecting AMD with Multiply Scattered Light Tomography

Elsner, Ann E.; Zhou, Qienyuan; Beck, Florian; Tornambe, Paul E.; Burns, Stephen A.; Weiter, John J.; Dreher, Andreas W.

doi:10.1007/978-94-010-0322-3_11

Cited by 17 publications

(26 citation statements)

References 12 publications

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“…By incorporating multiply scattered light into the images i.e. by using the large aperture [46], we were able to clearly see the smallest capillaries and the remodeling of the capillaries that occurred in the diabetic eyes as well as map the capillaries with intact flow using a variance based method [21]. The structural imaging enabled us to image the vascular walls and to quantify increases in the wall to lumen ratio of arterioles and increases in perifoveal capillary diameters in diabetic subjects.…”

Section: Discussionmentioning

confidence: 99%

In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy

Burns

Elsner

Chui

et al. 2014

Biomed. Opt. Express

125

139

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Abstract:We used a confocal adaptive optics scanning laser ophthalmoscope (AOSLO) to image the retina of subjects with nonproliferative diabetic retinopathy (NPDR). To improve visualization of different retinal features, the size and alignment of the confocal aperture were varied. The inner retinal layers contained clearly visualized retinal vessels. In diabetic subjects there was extensive capillary remodeling despite the subjects having only mild or moderate NPDR. Details of the retinal microvasculature were readily imaged with a larger confocal aperture. Hard exudates were observed with the AOSLO in all imaging modes. Photoreceptor layer images showed regions of bright cones and dark areas, corresponding in location to overlying vascular abnormalities and retinal edema. Clinically undetected intraretinal vessel remodeling and varying blood flow patterns were found. Perifoveal capillary diameters were larger in the diabetic subjects (p<0.01), and small arteriolar walls were thickened, based on wall to lumen measurements (p<.05). The results suggest that existing clinical classifications based on lower magnification clinical assessment may not adequately measure key vascular differences among individuals with NPDR.

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Section: Discussionmentioning

confidence: 99%

In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy

Burns

Elsner

Chui

et al. 2014

Biomed. Opt. Express

125

139

View full text Add to dashboard Cite

show abstract

“…In clinical disease, one of the strongest signs is often increased retinal scattering due to changes in tissue properties [15][16][17][18][19][20][21] . Most adaptive optics systems typically operate at high resolution and have a restricted field of view (1 to 3 degrees), making it difficult to identify the exact retinal locus of the high resolution view in relation to clinically observed changes.…”

Section: Introductionmentioning

confidence: 99%

Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope

et al. 2007

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We describe the design and performance of an adaptive optics retinal imager that is optimized for use during dynamic correction for eye movements. The system incorporates a retinal tracker and stabilizer, a wide field line scan Scanning Laser Ophthalmocsope (SLO), and a high resolution MEMS based adaptive optics SLO. The detection system incorporates selection and positioning of confocal apertures, allowing measurement of images arising from different portions of the double pass retinal point spread function (psf). System performance was excellent. The adaptive optics increased the brightness and contrast for small confocal apertures by more than 2x, and decreased the brightness of images obtained with displaced apertures, confirming the ability of the adaptive optics system to improve the pointspread function. The retinal image was stabilized to within 18 microns 90% of the time. Stabilization was sufficient for cross-correlation techniques to automatically align the images.

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“…9(C), black arrows). Compared to the AOSLO confocal structural image, the enhanced visualization of macular drusen on the AOSLO OP structural image suggests that the majority of the light returning from the drusen is multiply scattered light [43,44]. This implies that some retinal features can be imaged better using an AOSLO tuned intentionally for collecting multiply scattered light instead of direct back scattered light.…”

mentioning

confidence: 99%

Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging

Chui¹,

Dubow²,

Pinhas³

et al. 2014

Biomed. Opt. Express

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Recent advances to the adaptive optics scanning light ophthalmoscope (AOSLO) have enabled finer in vivo assessment of the human retinal microvasculature. AOSLO confocal reflectance imaging has been coupled with oral fluorescein angiography (FA), enabling simultaneous acquisition of structural and perfusion images. AOSLO offset pinhole (OP) imaging combined with motion contrast post-processing techniques, are able to create a similar set of structural and perfusion images without the use of exogenous contrast agent. In this study, we evaluate the similarities and differences of the structural and perfusion images obtained by either method, in healthy control subjects and in patients with retinal vasculopathy including hypertensive retinopathy, diabetic retinopathy, and retinal vein occlusion. Our results show that AOSLO OP motion contrast provides perfusion maps comparable to those obtained with AOSLO FA, while AOSLO OP reflectance images provide additional information such as vessel wall fine structure not as readily visible in AOSLO confocal reflectance images. AOSLO OP offers a noninvasive alternative to AOSLO FA without the need for any exogenous contrast agent. 458-461 (1990). 21. T. Hara, M. Inami, and T. Hara, "Efficacy and safety of fluorescein angiography with orally administered sodium fluorescein," Am.

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Detecting AMD with Multiply Scattered Light Tomography

Cited by 17 publications

References 12 publications

In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy

In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy

Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope

Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging

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