Detecting and delivering platinum anticancer drugs using fluorescent maghemite nanoparticles

Abstract

Rhodamine-embedded maghemite nanoparticles could act as fluorescent drug carriers to track and transport platinum anticancer drugs simultaneously.

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

“…8 They can also be used for delivery of drugs such as doxorubicin, platinum compounds, anti-inflammatory drugs, and prodrugs. [9][10][11][12] SPIONs are interesting nanoparticles with clinical potential both in the imaging field and for drug delivery.…”

Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose‐Coated Magnetic Nanoparticles

“…In addition, the fluorescent magnetic–cisplatin conjugates (prepared by Wang et al. ) showed lower cytotoxicity against the A549 cell line but slightly higher (1.35‐fold) cytotoxicity against A549R (cisplatin resistant cell line). An improved cytotoxicity of cisplatin magnetic complexes against tumor cells was achieved by Xing et al., whose magnetite–carboxymethylcellulose–cisplatin clusters exhibited 1.2‐fold (HepG2 cell line) and 3‐fold (HeLa cell line) increases in cytotoxicity, and by Munaweera et al., who improved the cytotoxicity of cisplatin after its incorporation together with a holmium radionuclide into a garnet magnetic nanoparticle (2.8‐fold increase in cytotoxicity against the A549 cell line).…”

“…Up to now, severalm agnetic polymeric formulations have been developed for the targeted specific delivery of platinum drugs. [13] Among them, polysaccharides (dextran, [14] alginate, [15] and carboxymethylcellulose (CMC) [16] )s eem to be interesting candidates for stabilizing MNPs. In general, polysaccharides are biocompatible polymers and, moreover,c arboxylated polysaccharides (alginate and CMC) can offer free carboxy groups for both the loading of cisplatin molecules and the binding of other molecules possessing ap rimary or secondary amine group, such as drugs, proteins, and fluorescent labels.…”

Theranostic Nanoemulsions: Codelivery of Hydrophobic Drug and Hydrophilic Imaging Probe for Cancer Therapy and Imaging

“…First, the pharmacokinetics of PTX and SRB were studied [37][38][39]. Then, their VE conjugates, PTX-VE and SRB-VE, in the TNE were investigated.…”