Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose‐Coated Magnetic Nanoparticles

Medříková, Zdenka; Novohradský, Vojtěch; Zajac, Juraj; Vrána, Oldřich; Kašpárková, Jana; Bakandritsos, Aristides; Petr, Martin; Zbořil, Radek; Brabec, Viktor

doi:10.1002/chem.201600949

Cited by 14 publications

(5 citation statements)

References 53 publications

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“…In essence, magnetic nanoparticles are state-of-the-art technology in the field of drug delivery since they can be modified with biocompatible polymers and biopolymers (poly(ethylene glycol) (PEG), cellulose, and alginic acid), carry molecular targeting agents and/or probe molecules (fluorescent labels), and simultaneously be imaged by magnetic resonance imaging (MRI). 6−9…”

Section: Introductionmentioning

confidence: 99%

Folic Acid-Functionalized, Condensed Magnetic Nanoparticles for Targeted Delivery of Doxorubicin to Tumor Cancer Cells Overexpressing the Folate Receptor

et al. 2019

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This study concerns the development of folic acid (FA)-functionalized iron oxide condensed colloidal magnetic clusters for a more selective delivery of doxorubicin (DOX) to tumor cancer cells overexpressing the folate receptor. Alginate-coated condensed magnetic nanoparticles (co-MIONs) were synthesized via an alkaline precipitation method of an iron precursor in the presence of sodium alginate. Poly(ethylene glycol) (OH-PEG-NH2) was conjugated to the carboxylic acid end group of alginate and folic acid (FA) was conjugated to the hydroxyl terminal group of PEG to produce folate-functionalized, pegylated co-MIONS (Mag-Alg-PEG-FA). The physicochemical properties of nanoparticles were fully characterized. DOX was loaded on the nanoparticles, and the cellular uptake and anticancer efficacy of the nanoparticles were examined in cancer cell lines expressing and not expressing the folate receptor. The biocompatibility of the carrier (blank nanoparticles) was also evaluated by cytocompatibility and hemocompatibility experiments. The nanoparticles exhibited sustained DOX release in aqueous buffers and biorelevant media, which was responsive to pH and external alternating current magnetic fields. The effect of the magnetic field on DOX percentage release appeared to be independent of the timing (onset time) of magnetic field application, providing flexibility to the magnetic control of drug release from the nanoparticles. The blank nanoparticles were not cytotoxic and did not cause hemolysis. The DOX-loaded and FA-functionalized nanoparticles exhibited increased uptake and caused increased apoptosis and cytotoxicity against the MDA-MB-231 cell line, expressing the folate receptor, compared to the MCF-7 cell line, not expressing the folate receptor. The application of a 0.5 T magnetic field during incubation of the nanoparticles with the cancer cells increased the cellular uptake and cytotoxicity of the nanoparticles. The obtained results indicate the potential of the folate-functionalized, pegylated co-MIONS for a more efficacious DOX delivery to cancer cells of solid tumors.

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Section: Introductionmentioning

confidence: 99%

Folic Acid-Functionalized, Condensed Magnetic Nanoparticles for Targeted Delivery of Doxorubicin to Tumor Cancer Cells Overexpressing the Folate Receptor

et al. 2019

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“…This behavior could be a consequence of the total formal charge of the PDO coating which is expected to remain constant after physical and/or chemical adsorption (with substitution of bonded chlorido with phenolate ligands 58−60 ) of the neutral cisplatin complex. Cisplatin loading on magnetic nanoclusters was studied in a previous work by Brabec et al 61 They have reported a study based on highly stable colloidal carboxymethylcellulose-coated magnetite nanoparticles (cMNPs) and cisplatin. The presence of a considerable amount of terminal carboxy groups at the magnetite surface, allowed, in that system, the formation of complexes with cisplatin.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Design and Application of Cisplatin-Loaded Magnetic Nanoparticle Clusters for Smart Chemotherapy

Mandriota

Corato

Benedetti

et al. 2018

ACS Appl. Mater. Interfaces

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One of the major challenges of drug delivery is the development of suitable carriers for therapeutic molecules. In this work, a novel nanoformulation based on superparamagnetic nanoclusters [magnetic nanocrystal clusters (MNCs)] is presented. In order to control the size of the nanoclusters and the density of magnetic cores, several parameters were evaluated and tuned. Then, MNCs were functionalized with a polydopamine layer (MNC@PDO) to improve their stability in aqueous solution, to increase density of functional groups and to obtain a nanosystem suitable for drug-controlled release. Finally, cisplatin was grafted on the surface of MNC@PDO to exploit the system as a magnetic field-guided anticancer delivery system. The biocompatibility of MNC@PDO and the cytotoxic effects of MNC@PDO− cisplatin complex were determined against human cervical cancer (HeLa) and human breast adenocarcinoma (MCF-7) cells. In vitro studies demonstrated that the MNC@PDO−cisplatin complexes inhibited the cellular proliferation by a dosedependent effect. Therefore, by applying an external magnetic field, the released drug exerted its effect on a specific target area. In summary, the MNC@PDO nanosystem has a great potential to be used in targeted nanomedicine for the delivery of other drugs or biofunctional molecules.

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“…Studies have shown that platinum metal nanoparticles can enhance the antitumor efficacy by regulating a variety of signal channels and activating the immune system [65][66][67]. Platinum nanoparticles have been widely used in clinical applications due to their excellent catalytic performance [68], imaging ability [69], excellent photothermal conversion ability, and radiosensitization ability [70]. Fu et al [71] performed lowmagnification (Figure 4(a)) and high-magnification SEM imaging (Figure 4(b)) and TEM imaging (Figure 4(c)) on mesoporous platinum nanoparticles.…”

Section: Platinum Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

Zhao

Xiang

Wang

et al. 2022

Bioinorganic Chemistry and Applications

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With the development of nanotechnology, noble metal nanoparticles are widely used in the treatment of cancer due to their unique optical properties, excellent biocompatibility, surface effects, and small size effects. In recent years, researchers have designed and synthesized a large number of nanomedicines that can be used for cancer treatment based on the morphology, physical and chemical properties, mechanism of action, and toxicological studies of noble metal nanoparticles. Furthermore, the integration of diagnosis and treatment, hyperthermia, cytotoxicity research, and drug delivery system based on the study of noble metal nanoparticles can be used as effective means for cancer treatment. This article focuses on the analysis of noble metal nanoparticles that are widely used in the treatment of cancer, such as gold nanoparticles, silver nanoparticles, platinum nanoparticles, and palladium nanoparticles. The various methods and mechanisms of action of noble metal nanoparticles in the treatment of cancer are objectively summarized in detail. Based on the research on the therapeutic safety and toxicity of noble metal nanoparticles, the development prospect of noble metal nanoparticles in the future clinical application is prospected.

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Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose‐Coated Magnetic Nanoparticles

Cited by 14 publications

References 53 publications

Folic Acid-Functionalized, Condensed Magnetic Nanoparticles for Targeted Delivery of Doxorubicin to Tumor Cancer Cells Overexpressing the Folate Receptor

Folic Acid-Functionalized, Condensed Magnetic Nanoparticles for Targeted Delivery of Doxorubicin to Tumor Cancer Cells Overexpressing the Folate Receptor

Design and Application of Cisplatin-Loaded Magnetic Nanoparticle Clusters for Smart Chemotherapy

Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

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