2017
DOI: 10.1186/s12918-017-0512-3
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Detecting causality from short time-series data based on prediction of topologically equivalent attractors

Abstract: BackgroundDetecting causality for short time-series data such as gene regulation data is quite important but it is usually very difficult. This can be used in many fields especially in biological systems. Recently, several powerful methods have been set up to solve this problem. However, it usually needs very long time-series data or much more samples for the existing methods to detect causality among the given or observed data. In our real applications, such as for biological systems, the obtained data or sam… Show more

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Cited by 8 publications
(3 citation statements)
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“…Accurate estimation of connectivity measures requires sufficient sample sizes [ 193 ]. Guidelines for sufficient sample sizes have been presented for different scenarios [ 194 , 195 , 196 ], whereas solutions for different applications with small samples have been proposed [ 197 , 198 , 199 ].…”
Section: Limitations and Pitfalls Of Connectivity Measuresmentioning
confidence: 99%
“…Accurate estimation of connectivity measures requires sufficient sample sizes [ 193 ]. Guidelines for sufficient sample sizes have been presented for different scenarios [ 194 , 195 , 196 ], whereas solutions for different applications with small samples have been proposed [ 197 , 198 , 199 ].…”
Section: Limitations and Pitfalls Of Connectivity Measuresmentioning
confidence: 99%
“…Accordingly, through Y's attractor manifold (a mathematical object that represents a geometric space in which the variable moves, usually denoted as M y ), it is possible to make local-neighborhood predictions on X's manifold M x . As local-neighborhood tests can be data demanding, several methods have been proposed to deal with short time series for noisy and high-dimensional systems (e.g., [56][57][58]).…”
Section: Physics-inspired Approachesmentioning
confidence: 99%
“… Integration of gene regulatory network inference with constraint-based metabolic models to simulate growth phenotype and exchange fluxes [ 15 ]. Causal relationship detection between gene pairs for short time-series gene expression data ( E. coli ; yeast) based on lagged-coordinate delay embedding theorem [ 16 ]. Cell fate predictions derived from polynomial modeling of human pancreatic single-cell gene expression data [ 17 ].…”
Section: Manuscript Submission and Reviewmentioning
confidence: 99%