Detecting esophageal disease with second-generation capsule endoscopy: initial evaluation of the PillCam ESO 2

Abstract

The PillCam ESO 2 demonstrated excellent visualization of the Z line. Compared with standard EGD, the PillCam ESO 2 had good test characteristics with high rates of detection of suspected Barrett's esophagus and esophagitis. This study provides indirect validation of the simplified ingestion procedure. The PillCam ESO 2 acquires high quality esophageal images, performs safely, and should be able to replace the current PillCam ESO.

Video Capsule Endoscopy: The Past, Present, and Future

“…Compared with EGD for detecting suspected Barrett's esophagus and esophagitis, the PillCam ESO2 had a sensitivity of 100% and a specificity of 74%, and a sensitivity of 80% and a specificity of 87%, respectively. The PillCam ESO2 demonstrated 86% agreement with EGD in describing the Z line [9].…”

Non-invasive (and minimally invasive) diagnosis of oesophageal varices

“…This emphasizes the importance of the learning curve for interpretation of the results of this technique. Recently, a new oesophageal capsule [55] and a new capsule ingestion procedure [56] have been introduced: the new capsule has improved technical characteristics, while the new ingestion procedure improves visualization of the lower esophagus. Whether these new features will improve the performance of the oesophageal capsule in detecting and grading oesophageal varices remains to be determined.…”

The Current Main Types of Capsule Endoscopy

“…Few studies reported very high specificity and sensitivity for the detection of erosive esophagitis and Barrett's esophagus (Fig. 2.11) [28,29], while others found much lower rates of sensitivity and specificity. A recent meta-analysis of seven studies involving 446 patients, ECE was found to have a sensitivity of 86 % and specificity 81 % in detecting esophageal varices (Fig.…”