2010
DOI: 10.1159/000324963
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Detecting p53 Immunoexpression inEsophageal Mucosa with Exfoliative Cytologyin Individuals at Risk for Squamous CellCarcinoma of the Esophagus

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Cited by 3 publications
(1 citation statement)
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“…Impaired p53 activity promotes the accumulation of DNA damage in cells without the induction of apoptosis. Commonly, p53 mutations appear to serve as a crucial early event in malignant transformation of Barrett's oesophagus and dysplastic squamous lesions to OAC and OSCC, respectively [173,174]. In addition, mutational status and p53 overexpression in oesophageal tumours have been correlated with poor survival and poor response to CRT in both OAC and OSCC [24,25,175,176].…”
Section: P53mentioning
confidence: 99%
“…Impaired p53 activity promotes the accumulation of DNA damage in cells without the induction of apoptosis. Commonly, p53 mutations appear to serve as a crucial early event in malignant transformation of Barrett's oesophagus and dysplastic squamous lesions to OAC and OSCC, respectively [173,174]. In addition, mutational status and p53 overexpression in oesophageal tumours have been correlated with poor survival and poor response to CRT in both OAC and OSCC [24,25,175,176].…”
Section: P53mentioning
confidence: 99%