Detection and distribution of zoonotic pathogens in wild Norway rats (Rattus norvegicus) from Tehran, Iran

Azimi, Taher; Azimi, Leila; Fallah, Fatemeh; Pourmand, Mohammad Reza; Dogaheh, Hadi Peeri; Tabatabaei, S. Rafiei

doi:10.1016/j.nmni.2021.100908

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…In 2021, seroreactivity against Rickettsia spp. was identified in 1% of rats in urban areas of Tehran, Iran [17]. Therefore, it is possible that Rickettsia spp.…”

Section: Discussionmentioning

confidence: 99%

“…Climatic conditions, specific vectors, and natural host restriction are the contributory factors for the endemicity of R. conorii in the Mediterranean region, including North Africa, southern Europe, and the Middle East. Limited data are available regarding rickettsial infections in Iran [8][9][10][11][12][13][14][15][16][17][18]. In a study conducted in 1995, a high proportion of positive human sera were identified by a rickettsial enzyme-linked immunosorbent assay (ELISA) (45%) kit in Iran.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever

et al. 2022

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Rickettsia conorii is the causative agent of Mediterranean spotted fever (MSF). Misdiagnosis of MSF may occur with febrile syndromes associated with rash and thrombocytopenia, such as Crimean-Congo hemorrhagic fever (CCHF). This study aimed to determine the prevalence of R. conorii among serum samples obtained from 260 suspected CCHF patients with features of MSF in Iran (2018–2020). The quantitative polymerase chain reaction (qPCR) method detected three (1.15%) positive 16S rDNA Rickettsia spp. samples that were classified as R. conorii subsp. conorii, R. conorii subsp. Israelensis, and R. helvetica using the sequencing of gltA, ompA, and 17kDa genes. Furthermore, R. conorii IgM antibodies presented in 38 (14.62%) patients by the enzyme-linked immunosorbent assay (ELISA) method. Out of 97 MSF patients with available paired serum samples, IgM seroconversion and a four-fold increase were observed in 14 (14.43%) and 12 (12.37%) patients, respectively. We concluded that rickettsial agents are present in Iran and may be misdiagnosed with other febrile syndromes.

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“…In 2021, seroreactivity against Rickettsia spp. was identified in 1% of rats in urban areas of Tehran, Iran [17]. Therefore, it is possible that Rickettsia spp.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever

et al. 2022

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“…All recently discovered severe infectious diseases in people are brought on by zoonotic pathogens. Even though a variety of factors, including interactions between animal reservoirs and the population at large, affect zoonotic transmission [ 1 , 2 ], events that act to lessen the ecological or physical distance between human and animal populations or to increase the density and abundance of these groups where they coexist raise the risk of zoonotic transmission [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Colonization by Campylobacter jejuni, Clostridium difficile, and Clostridium perfringens among Commensal Rattus norvegicus in the Urban Areas of Tehran, Iran

Azimi,

Nasrollahian,

Sabour

et al. 2024

BioMed Research International

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Background. Rattus norvegicus (R. norvegicus) population plays a significant role in the spread of numerous diseases in urban environments. The present study is aimed at investigating the presence of Campylobacter jejuni (C. jejuni), C. coli, Clostridium difficile (C. difficile), C. difficile toxigenic, and C. perfringens in R. norvegicus captured from urban areas of Tehran, Iran. Methods. From October 2021 to October 2022, 100 urban rats were trapped in 5 different districts of Tehran, Iran. The genomic DNA was extracted from fecal samples, and the presence of C. jejuni, C. coli, C. perfringens, and C. difficile species was evaluated using PCR assay. Moreover, PCR was used to assess the toxicity of C. difficile isolates. Results. Overall, 30% (n=30/100) of fecal samples were positive for zoonotic pathogens. Based on the PCR on hippuricase (hipO), glycine (gly), CIDIF, and phospholipase C (plc) genes, C. perfringens and C. difficile were isolated from 18.2% (n=14/77) and 5.2% (n=4/77) of male rats. The highest frequency of C. perfringens and C. jejuni was 25% (n=5/20) related to the south of Tehran. Toxigenic C. difficile was not detected in all regions. Conclusion. According to the findings, rats are the main reservoirs for diseases. Therefore, rodent control coupled with the implementation of surveillance systems should be prioritized for urban health.

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A global overview of the most important zoonotic bacteria pathogens transmitted from Rattus norvegicus to humans in urban environments

Sabour¹,

Azimi²,

Nasser³

et al. 2022

Infectious Medicine

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Detection and distribution of zoonotic pathogens in wild Norway rats (Rattus norvegicus) from Tehran, Iran

Cited by 5 publications

References 45 publications

Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever

Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever

Intestinal Colonization by Campylobacter jejuni, Clostridium difficile, and Clostridium perfringens among Commensal Rattus norvegicus in the Urban Areas of Tehran, Iran

A global overview of the most important zoonotic bacteria pathogens transmitted from Rattus norvegicus to humans in urban environments

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