Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review

Leus, Jasmine; Biervliet, S. Van; Robberecht, Eddy

doi:10.1007/s004310000507

Cited by 39 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At 6 months of age, all patients had levels <100 Ag/g and, by 12 months, all the children were insufficient, which was the clinical endpoint of the study. In a review on the detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis, Leus et al have evaluated E1 for neonatal screening for pancreatic insufficiency in CF as well as in the longitudinal follow up of pancreatic function [37]. They recommend that, once patients are on enzyme supplements, the 13 C mixed triglyceride breath test and acid steatocrit test give more clinical information in determining adequacy of supplementation as these tests reflect the adequacy of total-endogenous and exogenous enzyme function.…”

Section: Longitudinal Follow Up Of Exocrine Pancreatic Function In Cfmentioning

confidence: 99%

Fecal elastase-1: Utility in pancreatic function in cystic fibrosis

Daftary

Acton

Heubi

et al. 2006

Journal of Cystic Fibrosis

View full text Add to dashboard Cite

Early detection and management of pancreatic insufficiency is essential to optimize health and outcomes in cystic fibrosis patients. The gold standard measures for assessment of pancreatic function are direct pancreatic stimulation tests, which have numerous limitations. Estimation of fecal elastase-1 level to determine pancreatic function is an attractive alternative as the test is simple, rapid, cost-effective and easy to perform even in children. This review summarizes the data from studies reflecting the validity, limitation and advantages of fecal elastase-1 in assessing pancreatic function in cystic fibrosis patients.

show abstract

Section: Longitudinal Follow Up Of Exocrine Pancreatic Function In Cfmentioning

confidence: 99%

Fecal elastase-1: Utility in pancreatic function in cystic fibrosis

Daftary

Acton

Heubi

et al. 2006

Journal of Cystic Fibrosis

View full text Add to dashboard Cite

show abstract

“…Existem vários métodos descritos para avaliar a função exócrina do pâncreas, conforme relatado a seguir 34 .…”

Section: Insuficiência Pancreática (Ip)unclassified

Controvérsias na fibrose cística: do pediatra ao especialista

Ribeiro¹,

Ribeiro²,

Ribeiro³

2002

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

ResumoObjetivo: nos últimos 70 anos, a fibrose cística emergiu da obscuridade para o reconhecimento como a mais importante doença hereditária, potencialmente letal, incidente na raça branca. Embora seja uma doença genética, na qual o defeito básico acomete células de vários órgãos, nem todos os indivíduos expressam respostas clínicas na mesma intensidade. Várias manifestações clínicas, principalmente pulmonares e digestivas, podem ocorrer durante a vida dos pacientes fibrocísticos. O objetivo deste artigo é propiciar ao pediatra geral uma visão atualizada dos principais assuntos referentes à fibrose cística. Fontes dos dados:revisão sistemática e atualizada em fonte de dados oficial (Medline). Síntese dos dados:foram revisados 79 artigos sobre fibrose cística, de periódicos internacionais, colocando, de modo atual e crítico, os principais eventos relacionados com a incidência, a fisiopatogenia, as manifestações clínicas, o diagnóstico e o tratamento da fibrose cística.Conclusões: apesar de não existir cura para essa doença, muitos conhecimentos novos sobre a etiologia e a fisiopatologia, adquiridos nas duas últimas décadas, propiciaram uma nova abordagem para o tratamento da fibrose cística. A compreensão dos mecanismos básicos da doença pulmonar, bem como das manifestações digestivas na fibrose cística, decorrente dos conhecimentos de pesquisas recentes, tem sido a chave para o aumento da sobrevida e a melhora da qualidade de vida dos pacientes.J Pediatr (Rio J) 2002; 78 (Supl.2):S171-S186: fibrose cística, doenças pulmonares, criança. AbstractObjective: cystic fibrosis has become, in the last 70 years, the most important potentially fatal inherited disease that affects white individuals around the world. Although it is considered a genetic disorder, which strikes cells of different organs, not all patients present similar clinical response. Many clinical manifestations, mainly pulmonary and gastrointestinal, may develop in cystic fibrosis patients. The aim of this article is to offer pediatricians an updated review of the controversies and recent advances in the treatment of cystic fibrosis. Sources: systematic review in the Medline database.Summary of the findings: seventy-nine articles about cystic fibrosis published in international journals were reviewed. This article presents an updated and critical review of the main events related to the incidence, pathophysiology, diagnosis and treatment of cystic fibrosis.Conclusions: even though no treatment is available for this disease, new findings about its etiology and pathophysiology have been discovered in the last two decades, improving treatment and survival of cystic fibrosis patients.J Pediatr (Rio J) 2002; 78 (Supl.2): S171-S186: cystic fibrosis, respiratory tract diseases, child. Controvérsias na fibrose cística -do pediatra ao especialista Controversies in cystic fibrosis -from pediatrician to specialist IntroduçãoNos últimos 70 anos, a fibrose cística (FC) emergiu da obscuridade para o reconhecimento como a mais importante doença hereditária, potencia...

show abstract

“…The steatorrhoea, immunoreactive trypsin, FE-1, the triglycerides not increasing by a meal and the low cholesterol pointed towards a pancreatic insufficiency [5]. The C 13 MTG breath test confirmed our suspicion and was normalised by adding PERT to the test meal [1,8].…”

Section: Discussionmentioning

confidence: 84%

“…Different indirect tests can be used to prove pancreatic insufficiency [5]; however, the differential diagnosis of persistant diarrhoea after a gastrointestinal infection does not routinely include a search for exocrine pancreatic insufficiency. Even if an acute pancreatitis is caused by a viral infection, most are transient with no remaining damage.…”

Section: Introductionmentioning

confidence: 99%