Detection and genomic analysis of genital group B streptococcus in pregnant Korean women

Lee, Hwan Tae; Kim, Suk Young; Park, Pil-Whan; Ahn, Jeong Yeal; Kim, Kyung‐Hee; Seo, Ja Young; Jeong, Ji-Hun; Kwoun, Woo-Jae; Seo, Yiel-Hea

doi:10.1111/jog.13810

Cited by 7 publications

(12 citation statements)

References 40 publications

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“…In our study, the colonization of GBS was detected using the method of RT-PCR. Currently, there are various detection methods for GBS, including traditional culture, immunochromatographic detection, automatic microbial analysis and identification system and PCR methods [21,22]. The traditional culture method takes a long time, and its operation process is relatively difficult.…”

Section: Discussionmentioning

confidence: 99%

The effect of group B streptococcus on maternal and infants’ prognosis in Guizhou, China

et al. 2019

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Group B Streptococcus (GBS) is a kind of opportunistic pathogenic bacteria and mainly strikes the lower digestive tract and genitourinary tract. It is a major risk factor for neonatal babies, seriously threatening their lives. In the present study, we aimed to detect the GBS colonization in late pregnant women, and to study the effect of GBS on maternal and infants’ prognosis. Pregnant women with a gestational age of 35–37 weeks were enrolled in the study. Real-time polymerase chain-reaction (RT-PCR) was used to detect the colonization of GBS in the vaginal and rectal secretions for late pregnant women according to the screening guidelines. Chi-square test was applied to analyze the relationship between GBS colonization and clinical characteristics. A follow-up of 6 weeks was performed on the puerpera and infants after delivery. The positive rate of GBS was 12.6% in late pregnant women. GBS carrier state was positively related to several pregnancy outcomes, including intrauterine infection, premature rupture of membranes, postpartum hemorrhage, fetal distress and puerperal infection, as well as to part neonatal outcomes, containing neonatal infection, neonatal pneumonia and neonatal sepsis (all P < 0.05). GBS infection in late pregnant women results in adverse effects on maternal and neonatal outcomes.

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Section: Discussionmentioning

confidence: 99%

The effect of group B streptococcus on maternal and infants’ prognosis in Guizhou, China

et al. 2019

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“…This distribution is inconsistent with the recent reports on serotype distribution among young infants in Korea, in which serotypes III (44.6%), V (28.6%), and Ia (14.3%) predominated, and serotype Ib was found in only 10.7% of all cases [ 16 ]. The predominance of serotype Ib in invasive GBS infection among adults also differed from the result of a recent study on the vaginal-rectal colonization of GBS among pregnant women in Korea, in which serotype III was the most common (42.1%), followed by serotypes Ib (21.1%), V (15.8%), II (10.5%), and VI (5.3%) [ 17 ]. Based on the results of the studies involving adult patients in other countries, serotype V is among the commonly reported serotypes since the 1990s [ 5 , 18 ].…”

Section: Discussionmentioning

confidence: 69%

Clinical and molecular epidemiology of invasive group B Streptococcus infections in adults in a referral center in Korea

Lee

Kim

Song

et al. 2022

Eur J Clin Microbiol Infect Dis

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Invasive group B Streptococcus (GBS) infections are increasing among adults with underlying health conditions; however, clinical manifestations and serotype distribution remain unclear. This study investigated the molecular characteristics and antimicrobial resistance of invasive GBS in Korean adults. GBS isolates from patients with invasive diseases during 2006–2015 were investigated for capsular serotype, multilocus sequence type (ST), antimicrobial susceptibility, and resistance genes. Among the 74 isolates analyzed, the most common serotype was Ib (31.1%), followed by III (21.6%), V (20.3%), Ia (12.2%), and VI (12.2%). Thirteen STs were detected, with ST1, ST10, ST19, and ST23 as the most prevalent. The dominant capsular serotype exhibited by ST1 was V, and those expressed by ST10, ST19, and ST23 were Ib, III, and Ia, respectively. Erythromycin and levofloxacin resistance were observed in 33.8% and 31.1% of the isolates, respectively. ST10-Ib ( n = 11/11, 100%) and ST654-Ib ( n = 3/3, 100%) were dominant levofloxacin-resistant strains. Serotypes Ib, III, and V were most common among adults, which is inconsistent with recent reports in Korea where III, V, and Ia were predominant in infants. The difference in the serotype distribution between adults and children may be associated with the selective pressure imparted by antibiotics.

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“…In these regions, the predominance of serotypes Ia, IV, and V has also been reported and, to a lesser extent, serotypes VI, VIII, and IX 9,27,31,32,35,50 . According to Lee et al ., 10 the prevalence and distribution of GBS depend on the region of the study. Wang et al 19 .…”

Section: Discussionmentioning

confidence: 90%

Distribution and Prevalence of Serotypes of Group B Streptococcus Isolated from Pregnant Women in 30 Countries: A Systematic Review

Silva

Oliveira

et al. 2023

Maternal Fetal Med

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Objective: This review aimed to compile scientific data on the distribution and prevalence of group B Streptococcus (GBS) serotypes isolated from pregnant women across 30 countries from 2010 to 2019.Methods: This was a systematic review that addresses the distribution and prevalence of GBS in pregnant women. The search included studies published between January 2010 and December 2019 in PubMed, Virtual Health Library (BVS), ScienceDirect, Scientific Electronic Library Online (SciELO), and LILACS databases. We also surveyed relevant articles published in English, Spanish, and Portuguese between February and April 2020. Original articles, communication, short report, theses, and dissertations were included. The prevalence of GBS colonization, method for capsular serotyping, antimicrobial resistance, distribution and prevalence of serotypes were extracted from each study.Results: In all, 795 publications were identified. After applying the eligibility criteria, 48 articles were included for the final systematic analysis; most articles were from Asia and were published during the years 2014 to 2017. For the identification of serotypes, most studies used the polymerase chain reaction technique. There were records of all 10 GBS serotypes, namely, Ia, Ib, and II-IX, among the countries analyzed. GBS susceptibility and resistance to antibiotics were addressed in 37.5% of the publications analysed. Conclusion:This review showed that GBS serotypes are distributed differently in the 30 analyzed countries, with serotypes Ia, Ib, and II to V being the most prevalent. Furthermore, our results highlighted the relationship of GBS with maternal colonization, implications for neonates, and antibiotic resistance.

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Detection and genomic analysis of genital group B streptococcus in pregnant Korean women

Abstract: Direct real-time PCR using vaginal-rectal specimen could be used for detecting GBS in emergent conditions. Molecular serotypes III, Ib and V were most common. MLST analysis frequently presented ST-1, ST-19 and ST-862.

Cited by 7 publications

References 40 publications

The effect of group B streptococcus on maternal and infants’ prognosis in Guizhou, China

The effect of group B streptococcus on maternal and infants’ prognosis in Guizhou, China

Clinical and molecular epidemiology of invasive group B Streptococcus infections in adults in a referral center in Korea

Distribution and Prevalence of Serotypes of Group B Streptococcus Isolated from Pregnant Women in 30 Countries: A Systematic Review

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