Detection and identification of foot-and-mouth disease O/ME-SA/Ind-2001 virus lineage, Indonesia, 2022

Susila, Edy Budi; Daulay, Rosmalina Sari Dewi; Hidayati, Dewi Noor; Prasetyowati, Sapto Rini Budi; Wriningati, None; Andesfha, Ernes; Irianingsih, Sri Handayani; Dibia, I Nyoman; Faisal, F.; Supriyadi, Arif; Yupiana, Yuni; Hidayat, Muhammad; Zainuddin, Nuryani; Wibawa, Hendra

doi:10.1080/09712119.2023.2229414

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Indonesia, an archipelagic nation in Southeast Asia, is home to a diverse and substantial livestock industry, making it a vital contributor to the nation's economy and food security. FMD outbreaks have been reported previously in Indonesia resulting significant losses for livestock population and leading to challenges posed by the movement of animals across the country's vast and varied landscape (Susila et al, 2023). Between 2022-2023, the FMD outbreak occurred in Indonesia and this outbreak drew significant attention from the agricultural and veterinary public health sectors.…”

Section: Advances Inmentioning

confidence: 99%

Temporal Geospatial Mapping of Foot and Mouth Disease Outbreak in Aceh, Indonesia

AK,

Abrar,

Ferasyi

et al. 2024

AAVS

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Section: Advances Inmentioning

confidence: 99%

Temporal Geospatial Mapping of Foot and Mouth Disease Outbreak in Aceh, Indonesia

AK,

Abrar,

Ferasyi

et al. 2024

AAVS

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“…On February 5 2011 Japan was declared FMD-free. Meanwhile in Indonesia, FMD cases reappeared in May 2022 with O stereotype viruses (Susila et al, 2023). Until now (December 2023), Indonesia is still not free from FMD and has spread to 27 provinces out of a total of 38 provinces.…”

Section: Introductionmentioning

confidence: 99%

Economic Losses of Foot-and-Mouth Disease Based on Business Characteristics and Regional Policies in Indonesia and Japan

Kusumastuti,

Kobayashi,

Juwari

et al. 2024

AAVS

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Foot and Mouth Disease (FMD) is a strategic disease in cloven-hoofed animals according to the World Organisation for Animal Health or Office International Des Epizooties (OIE). The last case of the spread of FMD in Indonesia occurred in 2022 and Japan in 2010. This research aims to determine the value of economic losses based on the conditions of beef and dairy cattle farms in two regions, namely East Java Province and Miyazaki Prefecture based on the consideration that they are cattle production centers. SWOT analysis is used to support a description of the condition of internal factors (strengths and weaknesses) and external factors (opportunities and threats) of animal husbandry in two countries. Data analysis was carried out descriptively and quantitatively. Primary and secondary data were collected from July to September 2023. The results showed that economic losses due to FMD in cattle in Miyazaki Prefecture amounted to USD 775,184.77/farmer (beef cattle and dairy cattle), higher than losses in East Java province with USD 2,508.27/farmer for dairy cattle and USD 2,747.26/farmer for beef cattle. The high economic losses per farmer in Miyazaki are related to the characteristics of the number of livestock ownership and price of each animal. The results of the SWOT analysis show that the main weaknesses in East Java are limited facilities, budget, and livestock mobility conditions but the support of the central government and human resources supports the success of the FMD handling policy. In Miyazaki, policy support is dominated by facilities, human resources, and a strong budget even though there were problems with time accuracy in the initial case of FMD.

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“…In 2022, Indonesia had a FMD outbreak after 35 years of free cases of FMD [2]. The outbreak was first reported in East Java and then spread in other regions [3]. With the contagious nature of the disease and no specific drug available for this disease [4], viral inhibitors could be the alternative solution [5].…”

Section: Introductionmentioning

confidence: 99%

Beyond the Magic ofMoringa oleifera: Its Potential to Control Indonesian Serotype of Footand-Mouth-Disease Virus Replication through Inhibition of 3-Cysteine Protease

Kusuma,

Widyananda,

Grahadi

et al. 2024

BIO Web Conf.

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Foot-and-Mouth Disease (FMD) poses a significant threat to livestock worldwide, necessitating innovative approaches to combat its causative agent, the FMD virus (FMDV). On the other hand, Moringa oleifera is a feed alternative for cattles with numerous bioactive compounds. This paper delves into the captivating realm of Moringa oleifera (MO) bioactives and their potential in thwarting FMDV replication by targeting the essential enzyme, 3C Protease (3CP). To elucidate the inhibitory potential of these bioactives, a rigorous investigation involving molecular docking and molecular dynamics simulations was conducted. Specifically, the 3CP was modeled based on the amino acid sequence of FMDV Indonesian Serotype. Results showed that most of the compounds from MO outperformed Ribavirin as the standard therapy for FMD. Among them, Baicalin, Chlorogenic Acid, and Rutin have binding affinity -9.1, -8.1, and -8.1 kcal/mol, respectively. Those compounds also formed more hydrogen bonds than Ribavirin through their binding sites. Molecular dynamics simulation also revealed that interaction of 3CP with those compounds had minor influence on its structural stability. The conformation of those compounds is also more stable than Ribavirin, supported by more hydrogen bonds. In summary, this research highlighted the potential mechanism of MO bioactives in preventing severe FMDV infection through inhibition of viral replication.

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Detection and identification of foot-and-mouth disease O/ME-SA/Ind-2001 virus lineage, Indonesia, 2022

Cited by 4 publications

References 16 publications

Temporal Geospatial Mapping of Foot and Mouth Disease Outbreak in Aceh, Indonesia

Temporal Geospatial Mapping of Foot and Mouth Disease Outbreak in Aceh, Indonesia

Economic Losses of Foot-and-Mouth Disease Based on Business Characteristics and Regional Policies in Indonesia and Japan

Beyond the Magic ofMoringa oleifera: Its Potential to Control Indonesian Serotype of Footand-Mouth-Disease Virus Replication through Inhibition of 3-Cysteine Protease

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