Detection and Monitoring of Stem Cell Differentiation Using Nanotechnology

Askari, Esfandyar; Naghib, Seyed Morteza

doi:10.1007/7651_2019_272

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…The combination of nanotechnology and stem cells can maximize the therapeutic effects of stem cells. Nanoformulations can target and transport stem cells to specific sites and prolong the residence time, which not only improves the targeting of stem cell therapy but also reduces the adverse effects and can enhance the therapeutic effect and safety of stem cells to a great extent 335,336 . Despite numerous interesting studies, there is currently no uniform standard to describe the sequential manipulation of cells to obtain exosomes for clinical use.…”

Section: Discussionmentioning

confidence: 99%

“…Nanoformulations can target and transport stem cells to specific sites and prolong the residence time, which not only improves the targeting of stem cell therapy but also reduces the adverse effects and can enhance the therapeutic effect and safety of stem cells to a great extent. 335 , 336 Despite numerous interesting studies, there is currently no uniform standard to describe the sequential manipulation of cells to obtain exosomes for clinical use. Exosomes can change the microenvironment; however, the microenvironment can also change the composition of exosomes.…”

Section: Discussionmentioning

confidence: 99%

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Application of stem cells in regeneration medicine

Jin

et al. 2023

MedComm

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Regeneration is a complex process affected by many elements independent or combined, including inflammation, proliferation, and tissue remodeling. Stem cells is a class of primitive cells with the potentiality of differentiation, regenerate with self‐replication, multidirectional differentiation, and immunomodulatory functions. Stem cells and their cytokines not only inextricably linked to the regeneration of ectodermal and skin tissues, but also can be used for the treatment of a variety of chronic wounds. Stem cells can produce exosomes in a paracrine manner. Stem cell exosomes play an important role in tissue regeneration, repair, and accelerated wound healing, the biological properties of which are similar with stem cells, while stem cell exosomes are safer and more effective. Skin and bone tissues are critical organs in the body, which are essential for sustaining life activities. The weak repairing ability leads a pronounced impact on the quality of life of patients, which could be alleviated by stem cell exosomes treatment. However, there are obstacles that stem cells and stem cells exosomes trough skin for improved bioavailability. This paper summarizes the applications and mechanisms of stem cells and stem cells exosomes for skin and bone healing. We also propose new ways of utilizing stem cells and their exosomes through different nanoformulations, liposomes and nanoliposomes, polymer micelles, microspheres, hydrogels, and scaffold microneedles, to improve their use in tissue healing and regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Application of stem cells in regeneration medicine

Jin

et al. 2023

MedComm

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“…The protein corona of a nanosystem may be influenced by surface modifications on nanoparticles, such as antibodies, proteins, and peptides [ 99 , 100 , 101 , 102 ]. Surface modifications, including ligand features (nature, size, conformation, etc.…”

Section: Surface Decorationmentioning

confidence: 99%

Polymeric Nanoparticles and Nanogels: How Do They Interact with Proteins?

Sadeghi,

PourEskandar,

Askari

et al. 2023

Gels

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Polymeric nanomaterials, nanogels, and solid nanoparticles can be fabricated using single or double emulsion methods. These materials hold great promise for various biomedical applications due to their biocompatibility, biodegradability, and their ability to control interactions with body fluids and cells. Despite the increasing use of nanoparticles in biomedicine and the plethora of publications on the topic, the biological behavior and efficacy of polymeric nanoparticles (PNPs) have not been as extensively studied as those of other nanoparticles. The gap between the potential of PNPs and their applications can mainly be attributed to the incomplete understanding of their biological identity. Under physiological conditions, such as specific temperatures and adequate protein concentrations, PNPs become coated with a “protein corona” (PC), rendering them potent tools for proteomics studies. In this review, we initially investigate the synthesis routes and chemical composition of conventional PNPs to better comprehend how they interact with proteins. Subsequently, we comprehensively explore the effects of material and biological parameters on the interactions between nanoparticles and proteins, encompassing reactions such as hydrophobic bonding and electrostatic interactions. Moreover, we delve into recent advances in PNP-based models that can be applied to nanoproteomics, discussing the new opportunities they offer for the clinical translation of nanoparticles and early prediction of diseases. By addressing these essential aspects, we aim to shed light on the potential of polymeric nanoparticles for biomedical applications and foster further research in this critical area.

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Progress in the development and application of transitional technology of surface-enhanced Raman spectroscopy

Líu

et al. 2021

Colloid and Interface Science Communications

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Detection and Monitoring of Stem Cell Differentiation Using Nanotechnology

Cited by 3 publications

References 20 publications

Application of stem cells in regeneration medicine

Application of stem cells in regeneration medicine

Polymeric Nanoparticles and Nanogels: How Do They Interact with Proteins?

Progress in the development and application of transitional technology of surface-enhanced Raman spectroscopy

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