Detection and oncological effect of circulating tumour cells in patients with variant urothelial carcinoma histology treated with radical cystectomy

Abstract

CTC are detectable in about a quarter of patients with pure or variant UCB histology before RC, and represent an independent predictor for outcomes, when adjusting for histological subtype. In addition, our prospective data confirm the unfavourable influence of non-squamous cell-differentiated UCB on outcomes.

Detection and oncological effect of circulating tumour cells in patients with variant urothelial carcinoma histology treated with radical cystectomy

“…I read this article from Hamburg‐Eppendorf with great interest . The treatment of invasive urothelial carcinoma has not significantly progressed in the last 30 years, with survivals currently that are little changed since the first introduction of multi‐drug platinum‐based chemotherapy in the 1980s.…”

Liquid Biopsies to Select Patients for Perioperative Chemotherapy in Muscle-invasive Bladder Cancer: A Systematic Review

“…The presence of CTCs was associated with lymphovascular invasion, microvascular invasion, and positive soft tissue surgical margins, but not with lymph node metastasis. A weak association was found with pathological T stage (p = 0.065), and in a later paper (encompassing three extra patients) [22] the association became significant (p = 0.041). CTC-positive patients who underwent RC, with or without AC, had poorer recurrence-free survival (RFS; either local recurrence or metastatic recurrence) than CTC-negative patients (2- , p < 0.001).…”

“…Multiple groups confirmed the detection of CTCs in nmBC patients in small patient sets [17][18][19]. The largest dataset on CTCs in nmBC patients to date has been published by the Hamburg group on several occasions [20][21][22][23]. Their most recent analysis encompassed 185 nmBC patients (69% with pathological MIBC) undergoing RC without NAC, of whom 50 patients received AC (patients with !…”

The association between variant urothelial histologies, pathological stage and disease specific survival in patients with bladder cancer

“…Three and 5 year DSSs were found to be 71.9±2% and 67.9±2%; 27.6±9% and 18.4±8% for the groups, respectively. Recently, Soave et al [14] reported the relationship between preoperative circulating tumor cells (CTC) count, BC histopathology and survival of 188 patients. They reported that patients with non-squamous differentiation had inferior recurrence free survival (RFS), compared to patients with PUH and patients with squamous cell differentiation (p=0.016).…”