Detection Beyond Debye's Length with an Electrolyte‐Gated Organic Field‐Effect Transistor

Palazzo, Gerardo; Tullio, Donato De; Magliulo, Maria; Mallardi, Antonia; Intranuovo, Francesca; Mulla, Mohammad Yusuf; Favia, Pietro; Vikholm-Lundin, Inger; Torsi, Luisa

doi:10.1002/adma.201403541

Cited by 193 publications

(197 citation statements)

References 21 publications

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“…A strategy may be to switch from This result creates opportunities for sensor applications. Indeed, water is the natural environment for biological receptors [30]. In this case, water must act both as the electrolyte and the media responsible for carrying the analytic sample, which is the current challenge to develop EGOFET-based biosensors.…”

Section: Egofetsmentioning

confidence: 99%

“…(A) In order to investigate the transduction mechanisms of such EGOFET devices, Palazzo et al [30] investigated in 2014 the sensitivity of their EGOFET as a function of the Debye's length, the receptor charge, and the distance at which the binding event takes place. For this, they used biotin/avidin and antigen/antibody interactions (C-reactive protein CRP and anti-CRP, respectively).…”

Section: P3ht-based Egofet For Protein (Streptavidin) Detectionmentioning

confidence: 99%

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Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

2016

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Electrolyte-gated organic field-effect transistors have emerged in the field of biosensors over the last five years, due to their attractive simplicity and high sensitivity to interfacial changes, both on the gate/electrolyte and semiconductor/electrolyte interfaces, where a target-specific bioreceptor can be immobilized. This article reviews the recent literature concerning biosensing with such transistors, gives clues to understanding the basic principles under which electrolyte-gated organic field-effect transistors work, and details the transduction mechanisms that were investigated to convert a receptor/target association into a change in drain current.

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Section: Egofetsmentioning

confidence: 99%

Section: P3ht-based Egofet For Protein (Streptavidin) Detectionmentioning

confidence: 99%

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

2016

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“…Low pressure (LP) plasmas are still mostly utilized in this highly interdisciplinary field, for producing cell-adhesive layers on flat or within porous substrates, functionalized surfaces decorated with biomolecules, non fouling coatings, anti-bacterial surfaces and films with hydrogel properties just to mention a few examples [1][2][3][4][5][6][7][8][9]. AP plasmas are now also utilized for surface modification of biomedical materials as well as for sterilization [10][11][12].…”

mentioning

confidence: 99%

Investigation of air-DBD effects on biological liquids for in vitro studies on eukaryotic cells

Trizio

Sardella

Francioso

et al. 2015

Clinical Plasma Medicine

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“…The observed coupling of the substrate with the electrolyte en3 vironment is consistent with the operations of biosensors where the recognition moiety is grafted on the substrate and embedded under the semiconductor thin film. 30 In that case, the analyte (biotin) is even much larger than hydronium ions that are relevant to our study. The substrate therefore acts as a second auxiliary gate in the EGOFET architecture, as it induc3 es a much stronger capacitive coupling with respect to the hitherto accepted scenario governed solely by the electrolyte.…”

Section: Discussionmentioning

confidence: 99%

The Substrate is a pH-Controlled Second Gate of Electrolyte-Gated Organic Field-Effect Transistor

Lauro

Casalini

Berto

et al. 2016

ACS Appl. Mater. Interfaces

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Electrolyte3gated organic field3effect transistors (EGOFETs), based on ultra3thin pentacene films on quartz, were operated with electrolyte solutions whose pH was systematically changed. Transistor parameters exhibit non3monotonic variation vs pH, which cannot be accounted for by capacitive coupling through the Debye3Helmholtz layer. The data were fitted with an ana3 lytical model of the accumulated charge in the EGOFET where Langmuir adsorption was introduced to describe the (pH3 dependent) charge build3up at the quartz surface. The model provides an excellent fit to the threshold voltage and transfer charac3 teristics as a function of pH, which demonstrates that quartz acts as a second gate controlled by pH, and is mostly effective at neu3 tral or alkaline pH. The effective capacitance of the device is always greater than the capacitance of the electrolyte, thus highlight3 ing the role of the substrate as an important active element for amplification of the transistor response. INTRODUCTIONSince the pioneering work of Bergveld 1 several examples of field3effect transistors (FETs) have been demonstrated as sen3 sors working in aqueous solutions. 2 In the ion3sensing field3 effect transistor (ISFET), a reference electrode controls the potential of an electrolyte solution at the interface with a met3 al3oxide3semiconductor FET (MOSFET). The ISFET is a po3 tentiometric sensor that responds to the activity of ions, in par3 ticular hydronium ions, at the electro3 lyte/dielectric/semiconductor interface. Ion3sensitive organic field3effect transistors (ISOFETs) were also demonstrated, where the channel consists of an organic semiconductor (OSC) thin film. 3,4 In these architectures, an encapsulation layer sepa3 rating the organic semiconductor thin film from the aqueous environment has been used. Both inorganic (e.g. silicon ni3 tride 3 and tantalum pentoxide 4 ) and organic (e.g. poly(methyl methacrylate) 5 and poly(vinylidene fluoride)) 6 dielectrics were exploited to yield pH3sensitive devices. It is also possible to operate the IS(O)FET in a dual gate archi3 tecture, where the bottom gate consists of a metal electrode separated by a (bottom) dielectric, and the top gate electrode controls the bath potential. The two gates are operated inde3 pendently, giving rise to a dual channel in a thick film (if the signs of gate voltages are the same) or depleting one of the channels (if their signs are opposite). It was shown 7,8 that the device responds with a shift of threshold voltage to changes of the top3gate potential. The shift observed is proportional to (the negative of) the potential change at the top gate, through a capacitive coupling given by the ratio of the top and bottom

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Detection Beyond Debye's Length with an Electrolyte‐Gated Organic Field‐Effect Transistor

Cited by 193 publications

References 21 publications

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

Investigation of air-DBD effects on biological liquids for in vitro studies on eukaryotic cells

The Substrate is a pH-Controlled Second Gate of Electrolyte-Gated Organic Field-Effect Transistor

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