A new approach is proposed in the paper for un-that automated control algorithms capable of tight regulation known glucose inlet estimation in case of diabetic patients under for glucose intolerant ICU patients would reduce mortality, insensitive care in form of a Linear Parameter Varying (LPV) as well the current burden on ICU medical resources and model class. The nonlinear two compartment glucose-insulin time system is rewritten in affine parameter varying form in order des to handle the dynamics with LPV Fault Detection and IsolationTo design an appropriate control, an adequate model is (FDI) method. The aim of the closed-loop fault detection, on necessary. In the last 50 years, a variety of models for the the one hand, is to estimate the unknown disturbance input interaction between glucose and insulin have been suggested.of the system, on the other hand to recognize the actuator However, the simplest model proved to be the minimal fault. A parameter varying controller assures the performance model of (Bergman et al., 1979), but its shortcoming is its requirements and stability Of the system.FDquiremeLPV,a csebinliny system, big sensitivity to variance in the parameters and that the Problem inVRecsle-neaion plasma insulin concentration must be known as a function Problem in Residual Generation of time. Therefore, extensions of this minimal model have