Detection of acetazolamide-induced increase in organ blood flow in rabbits by laser flowmetry

Taki, Kenji; Nagasawa, Ichirou; Hirahara, Kenji; Tomita, Shinji; Baba, Nobuo; Totoki, Tadahide

doi:10.1007/bf02480036

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…Laser Doppler flowmetry for the measurement of tissue blood flow is least invasive, simple to apply and provides a continuous record. This method has been used to measure perfusion of various tissues [9], such as liver [10], kidney [10], spinal cord [11] or nerve root [12]. Hughes and colleagues [12] studied the blood flow changes in the nerve root using laser Doppler flowmetry during decompressive surgery of the spine, and suggested that it might be useful.…”

Section: Discussionmentioning

confidence: 99%

Perineural injection to nerve root and radicular blood flow: a clinical study during spinal surgery

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Perineural injection to nerve root and radicular blood flow: a clinical study during spinal surgery

et al. 2001

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Acetazolamide-induced increase in blood flow to rabbit organs is confirmed using colored microspheres

Taki¹,

Hirahara²,

Tomita³

et al. 1998

Heart Vessels

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Inhibitors of carbonic anhydrase activity have been found to increase blood and organ PCO2 and to increase blood flow (BF) in individual organs. To determine whether carbonic anhydrase inhibition coordinately induces an increase in BF in several organs, we assayed the effect of the carbonic anhydrase inhibitor, acetazolamide (AZ), on BF in rabbit organs using the colored microsphere (CM) assay. Eight female white rabbits were anesthetized with ketamine and urethane, and administered three sequential doses of 4 mg/kg AZ. After each dose, the rabbits were injected with 9 x 10(5) CMs of different colors, and arterial blood was collected. We found that AZ had no effect on blood pressure, body temperature, hemoglobin concentration, or PaCO2. In contrast, 12 mg/kg AZ significantly increased PaO2 and significantly decreased base excess. When we measured organ BF, we observed, in response to 12 mg/kg AZ, an 82% increase in brain BF and a 55% increase in kidney BF, but no change in BF of the liver, stomach wall, or abdominal muscle. These findings suggest that the inhibition of carbonic anhydrase activity by AZ, which decreases the rate of CO2 conversion to HCO3-, causes the retention of CO2 in tissues and organs, and thus increases BF in specific organs. Administration of carbonic anhydrase inhibitors, such as AZ, may increase BF to the brain and kidney without reducing PaO2, thereby increasing the supply of oxygen in conditions involving hypoxia such as ischemia and shock.

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Changes in leukocyte migration during carbonic anhydrase activity inhibition

Kawaai

Seino

Yamazaki

et al. 2009

Burns

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Detection of acetazolamide-induced increase in organ blood flow in rabbits by laser flowmetry

Cited by 7 publications

References 21 publications

Perineural injection to nerve root and radicular blood flow: a clinical study during spinal surgery

Perineural injection to nerve root and radicular blood flow: a clinical study during spinal surgery

Acetazolamide-induced increase in blood flow to rabbit organs is confirmed using colored microspheres

Changes in leukocyte migration during carbonic anhydrase activity inhibition

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