Detection of acetone and isoprene in human breath using a combination of thermal desorption and selected ion flow tube mass spectrometry

Hryniuk, Alexa; Ross, Brian M.

doi:10.1016/j.ijms.2009.02.027

Cited by 53 publications

(40 citation statements)

References 22 publications

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“…Using standard samples the linearity of this system has been demonstrated within the concentration range from 1 to 10 ppb (Ross & Vermeulen, 2007). Hryniuk and Ross (2009) have now successfully used this ATD/SIFT-MS combination for breath analysis and found that there was a 1 to 1 concordance between the levels of isoprene and acetone in the breath of 12 healthy volunteers as measured using this combination technique and direct real-time SIFT-MS measurements.…”

Section: Recent Extensions To Sift-msmentioning

confidence: 87%

“…The performance of Profile 3 SIFT-MS instruments has been illustrated by the data presented in several research papers produced by the teams at Keele , 2009Smith et al, 2008;Wang et al, 2008a;Wang, Š paněl, & Smith, 2008b;, at Prague (Španěl, Dryahina, & Smith, 2007a,b,c) and at Thunder Bay (Ross & Vermeulen, 2007;Ross, 2008;Hryniuk & Ross, 2009;Ross, Babay, & Ladouceur, 2009;). Scrutiny of these papers reveals the value and the quality of trace gas analyses obtained using current Profile 3 instruments.…”

Section: Performance Of the Profile 3 Instrumentmentioning

confidence: 99%

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Progress in SIFT‐MS: Breath analysis and other applications

Španěl

Smith

2011

Mass Spectrometry Reviews

310

255

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The development of selected ion flow tube mass spectrometry, SIFT-MS, is described from its inception as the modified very large SIFT instruments used to demonstrate the feasibility of SIFT-MS as an analytical technique, towards the smaller but bulky transportable instruments and finally to the current smallest Profile 3 instruments that have been located in various places, including hospitals and schools to obtain on-line breath analyses. The essential physics and engineering principles are discussed, which must be appreciated to design and construct a SIFT-MS instrument. The versatility and sensitivity of the Profile 3 instrument is illustrated by typical mass spectra obtained using the three precursor ions H(3)O(+), NO(+) and O(2)(+)·, and the need to account for differential ionic diffusion and mass discrimination in the analytical algorithms is emphasized to obtain accurate trace gas analyses. The performance of the Profile 3 instrument is illustrated by the results of several pilot studies, including (i) on-line real time quantification of several breath metabolites for cohorts of healthy adults and children, which have provided representative concentration/population distributions, and the comparative analyses of breath exhaled via the mouth and nose that identify systemic and orally-generated compounds, (ii) the enhancement of breath metabolites by drug ingestion, (iii) the identification of HCN as a marker of Pseudomonas colonization of the airways and (iv) emission of volatile compounds from urine, especially ketone bodies, and from skin. Some very recent developments are discussed, including the quantification of carbon dioxide in breath and the combination of SIFT-MS with GC and ATD, and their significance. Finally, prospects for future SIFT-MS developments are alluded to.

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Section: Recent Extensions To Sift-msmentioning

confidence: 87%

Section: Performance Of the Profile 3 Instrumentmentioning

confidence: 99%

Progress in SIFT‐MS: Breath analysis and other applications

Španěl

Smith

2011

Mass Spectrometry Reviews

310

255

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“…Breath analysis is a promising field for non-invasive diagnosis ( [208]; [183]) but the necessity for large screening studies to find markers for diseases and validate the results brings logistic challenges with: (1) the storage of breath samples for off-line analysis [193]; [209]) and (2) the standardization of the sampling method ( [210]; [34]). With a small scale test, the first point is addressed by looking at specific volatiles known to be present in elevated or decreased levels.…”

Section: Resultsmentioning

confidence: 99%

Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences

Gonzalez

2012

Mass Spectrometry Handbook

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“…SIFT-MS emerged as a new technology for detection of exhaled breath gases in humans (Spanel et al, 2006;Pysanenko et al, 2008;Hryniuk and Ross, 2009). SIFT-MS can analyze complex mixtures regardless of the water vapor content in real time without sample preparation.…”

Section: 4selected Ion Flow Tube Mass Spectrometry (Sift-ms)mentioning

confidence: 99%

“…Figure 14 shows the schematic representation of the flowing after 25 glow-selected ion flow tube (FA-SIFT) instrument. Acetone, acetaldehyde, ammonia, ethanol and water vapor were measured by SIFT-MS at ppbv level in a single-breath exhalation in real time (Scotter et al, 2005;Hryniuk and Ross, 2009 downstream quadrupole and detected using a particle multiplier producing the resulting mass spectrum. Thus, quantification of particular trace gases in the air sample is achieved.…”

Section: 4selected Ion Flow Tube Mass Spectrometry (Sift-ms)mentioning

confidence: 99%

A microreactor approach for chemoselective capture and analysis of carbonyl compounds in air and exhaled breath.

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Li, Mingxiao, "A microreactor approach for chemoselective capture and analysis of carbonyl compounds in air and exhaled breath." (2013) Finally, exhaled breath samples from patients with untreated lung cancer (LC) patients, patients with benign pulmonary nodules and healthy volunteers (smokers and non-smokers) were collected and analyzed using the same method. The FTICR-MS spectra showed that the exhaled breath samples from LC patients have a unique pattern of VOCs, in comparison with healthy controls and patients with benign pulmonary nodules.2-Butanone, hydroxy-acetaldehyde, 3-hydroxy-2-butanone, and 4-hydroxy-hexenal (4-HHE) were found to have significant higher concentrations for LC patients. A simple diagnosis method based on four elevated VOCs could easily discriminate lung cancer patients from healthy controls and patients with pulmonary nodules with 90.6% diagnosis sensitivity and 81.3% specificity.vii

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Detection of acetone and isoprene in human breath using a combination of thermal desorption and selected ion flow tube mass spectrometry

Cited by 53 publications

References 22 publications

Progress in SIFT‐MS: Breath analysis and other applications

Progress in SIFT‐MS: Breath analysis and other applications

Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences

A microreactor approach for chemoselective capture and analysis of carbonyl compounds in air and exhaled breath.

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