Detection of Acinetobacter pittii ST220 co-producing NDM-1 and OXA-820 carbapenemases from a hospital sink in a non-endemic country of NDM

Iimura, Masaki; Hayashi, Wataru; Arai, Eriko; Natori, Tatsuya; Horiuchi, Kazuki; Matsumoto, Go; Tanaka, Hisataka; Soga, Eiji; Nagano, Yukiko; Nagano, Noriyuki

doi:10.1016/j.jgar.2019.11.013

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…Here we report the occurrence of A. lwoffii clinical isolate co-harboring blaNDM-1 and a novel blaOXA-915 carbapenemase gene in Japan. We also demonstrate that the NDM-1-encoding plasmid harbored by A. lwoffii clinical isolate obtained from an inpatient analyzed in this study exhibited significant sequence identity with that harbored by previously described A. pittii, which had been detected one year earlier from a hospital sink in the same ward (5).…”

Section: Accepted Manuscriptsupporting

confidence: 74%

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Occurrence of blaNDM-1 in a Clinical Isolate of Acinetobacter lwoffii in Japan: Comparison of blaNDM-1-Harboring Plasmids between A. lwoffii and A. pittii Originated from a Hospital Sink

et al. 2021

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Section: Accepted Manuscriptsupporting

confidence: 74%

“…the CLSI broth microdilution method. The presence of the blaNDM gene was identified by PCR and sequencing(5). WGS analysis was performed using Illumina NovaSeq6000 and de novo assembled by the A5-miseq pipeline.…”

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confidence: 99%

Occurrence of blaNDM-1 in a Clinical Isolate of Acinetobacter lwoffii in Japan: Comparison of blaNDM-1-Harboring Plasmids between A. lwoffii and A. pittii Originated from a Hospital Sink

et al. 2021

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“…Both genetic and virulence determinant information of this species are scarce, and usually extrapolated from the genomic analysis of A. baumannii, due to their high genomic similarity [16]. While A. pittii is commonly more sensitive to antimicrobial agents than A. baumannii, both MDR and XDR strains have been found as a source of ICU outbreaks and nosocomial infections [7,10,12,17]. Therefore, new studies contributing to the understanding of these mechanisms are required.…”

Section: Introductionmentioning

confidence: 99%

Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes

2022

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Antimicrobial-resistant pathogenic bacteria are an increasing problem in public health, especially in the healthcare environment, where nosocomial infection microorganisms find their niche. Among these bacteria, the genus Acinetobacter which belongs to the ESKAPE pathogenic group harbors different multi-drug resistant (MDR) species that cause human nosocomial infections. Although A. baumannii has always attracted more interest, the close-related species A. pittii is the object of more study due to the increase in its isolation and MDR strains. In this work, we present the genomic analysis of five clinically isolated A. pittii strains from a Spanish hospital, with special attention to their genetic resistance determinants and plasmid structures. All the strains harbored different genes related to β-lactam resistance, as well as different MDR efflux pumps. We also found and described, for the first time in this species, point mutations that seem linked with colistin resistance, which highlights the relevance of this comparative analysis among the pathogenic species isolates.

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“…It is speculated that they can help the host adapt to more complex environments and resist harsh ones. C. lapagei (OTU2), Achromobacter ruhlandii (OTU1) and P. hibiscicola (OTU24) were also reported to have resistant genes [ 59 , 60 , 61 , 62 ]. Similarly, the higher environmental adaptability and resistance of intestinal bacteria from C. punctiferalis were confirmed by functional analysis, such as xenobiotics biodegradation and metabolism (Level 2), drug metabolism-other enzymes (Level 3), chloroalkane and chloroalkene degradation (Level 3), aminobenzoate degradation (Level 3), naphthalene degradation (Level 3), environmental adaptation (Level 2), metabolism of terpenoids and polyketides (Level 2).…”

Section: Discussionmentioning

confidence: 99%

Intestinal Bacterial Diversity and Functional Analysis of Three Lepidopteran Corn Ear Worm Larvae

Zhang

Gao

Zheng

et al. 2022

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Insects, as the most abundant animal group on earth, and their symbionts help their hosts to adapt to various environments. Conogethes punctiferalis, Ostrinia furnacalis and Helicoverpa armigera are three main pests co-occurring in the ear stage of corn, which significantly affect the yield and quality of corn. The purpose of this study was to compare the diversity and function of the intestinal bacteria of the three co-occurring lepidopteran pests, C. punctiferalis, O. furnacalis and H. armigera, and to explore the reason of their prevalence from the microbiota’s view. Our results showed the difference of diversity and abundance of the gut bacteria of three co-occurring lepidopteran pests at the ear stage. Proteobacteria and Firmicutes were the dominant phyla, and the Enterobacteriaceae and Enterococcaceae were the dominant families in the three pests. Compared with the other two pests, Bacteroidetes was found much more in C. punctiferalis. In addition, C. punctiferalis showed more correlation and similarity in bacteria composition with corn endophytic bacteria, as well as had obvious advantages in metabolic, environmental information processing, cellular processes and organic systems function pathways. Our findings may provide insight into the prevalence of corn earworm larvae from the perspective of gut microbiota and function prediction.

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Detection of Acinetobacter pittii ST220 co-producing NDM-1 and OXA-820 carbapenemases from a hospital sink in a non-endemic country of NDM

Cited by 9 publications

References 17 publications

Occurrence of<i> bla</i><sub>NDM-1</sub> in a Clinical Isolate of <i>Acinetobacter lwoffii</i> in Japan: Comparison of<i> bla</i><sub>NDM-1</sub>-Harboring Plasmids between <i>A. lwoffii</i> and <i>A. pittii</i> Originated from a Hospital Sink

Occurrence of<i> bla</i><sub>NDM-1</sub> in a Clinical Isolate of <i>Acinetobacter lwoffii</i> in Japan: Comparison of<i> bla</i><sub>NDM-1</sub>-Harboring Plasmids between <i>A. lwoffii</i> and <i>A. pittii</i> Originated from a Hospital Sink

Genetic Resistance Determinants in Clinical Acinetobacter pittii Genomes

Intestinal Bacterial Diversity and Functional Analysis of Three Lepidopteran Corn Ear Worm Larvae

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