Detection of anti-type VII collagen antibody in Sjögren's syndrome/lupus erythematosus overlap syndrome with transient bullous systemic lupus erythematosus

Fujii,; Fujimoto,; Ueda,; Makino,; Arata,

doi:10.1046/j.1365-2133.1998.02372.x

Cited by 20 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2d). Immunoblot analysis using dermal extracts and extracellular matrix (ECM) protein from cultured keratinocytes prepared as described previously (14–16) showed that the patient's sera reacted with 290 kDa type VII collagen in dermal extract (Fig. 3) but not with the ECM protein including laminin 5 (not shown).…”

Section: Case Reportmentioning

confidence: 79%

Bullous Systemic Lupus Erythematosus as an Initial Manifestation of SLE

Fujimoto

Hamada

Yamada

et al. 2005

The Journal of Dermatology

View full text Add to dashboard Cite

Bullous systemic lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus that is often associated with autoimmunity to type VII collagen. We describe a 45-year-old woman with BSLE who presented with vesiculobullous lesions as an initial manifestation of SLE. The patient first noticed a widespread urticarial, erythematous eruption associated with tense blisters, erosions, and crusting. She was diagnosed with bullous pemphigoid and underwent a one-month course of treatment with betamethazone. Because of the appearance of marked proteinuria, a subsequent renal biopsy, and serological tests, the patient was diagnosed with rapidly progressive glomerulonephritis and systemic lupus erythematosus. The patient's IgG circulating antibodies labeled the dermal floor of salt-split skin and recognized type VII collagen in immunoblot studies. Although methylprednisolone pulse therapy for glomerulonephritis did not alleviate the vesicullobullous eruption, treatment with dapsone resulted in dramatic disappearance of the lesions. Cessation of dapsone therapy due to hemolysis with Heinz-body formation did not aggravate the bullous disease. Our case illustrates that a generalized vesiculobullous eruption can be the sole presenting manifestation of SLE. It also emphasizes the close temporal relationship between BSLE and lupus nephritis.

show abstract

Section: Case Reportmentioning

confidence: 79%

Bullous Systemic Lupus Erythematosus as an Initial Manifestation of SLE

Fujimoto

Hamada

Yamada

et al. 2005

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…A similar finding was also previously reported in a patient with Sjögren’s syndrome/SLE overlap with BSLE whose anti-type VII collagen IgG were undetectable at the time of BSLE remission. 14 The rise and fall in levels of anti-type VII collagen autoantibodies during the course of the patient’s BSLE disease implies that they have possible utility as biomarkers, which can be used to assess disease activity and guide treatment.…”

Section: Discussionmentioning

confidence: 99%

Detection of Type VII Collagen Autoantibodies Before the Onset of Bullous Systemic Lupus Erythematosus

et al. 2015

View full text Add to dashboard Cite

Importance Anti-type VII collagen autoantibodies are often detectable in patients with bullous systemic lupus erythematosus (BSLE); however their timing of appearance preceding onset of disease is unknown. Observations We report the case of a 50-year-old female with a history of systemic lupus erythematosus who presented with vesicles and bullae around her lips, trunk, axillae, arms, and thighs. Histologic analysis as well as immunofluorescence and immunoblot studies confirmed the diagnosis of BSLE. Immunoblotting and ELISA studies of the patient’s serum obtained three months prior to the onset of BSLE showed presence of anti-type VII collagen autoantibodies. Levels of anti-type VII collagen IgG increased after bullous lesions appeared. Within one month after initiating dapsone and increasing the dose of prednisone, skin lesions promptly resolved. A year after onset of BSLE, her anti-type VII collagen IgG decreased below levels observed prior to the inception of her bullous lesions. Conclusions and Relevance This study shows that anti-type VII collagen autoantibodies can precede the clinical appearance of BSLE. The subsequent increase and decrease in the levels of circulating anti-type VII collagen autoantibodies, which mirrored skin disease activity, support a potential role in their initiation of disease.

show abstract

“…Serological evaluations have shown the frequent presence of rheumatoid factor, elevated immunoglobulin levels (hypergammaglobulinemia) and anti-nuclear autoantibodies, especially anti-SS-A/Ro and anti-SS-B/La antibodies. Additional autoantibodies react with numerous cellular components of the exocrine glands, probably representing spreading epitopes (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Of late, intense interest has revolved around antibodies to the muscarinic acetylcholine type-3 receptor (M3R) (34-42).…”

Section: Sjs In Humans 221 General Features -What Constitutes Sjs?mentioning

confidence: 99%

Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies

Nguyen¹

2007

Front Biosci

View full text Add to dashboard Cite

Sjögren's syndrome (SjS) is a systemic autoimmune disease in which an immunological attack against the salivary and lacrimal glands results, respectively, in severe dry mouth and dry eye diseases. Although a CD4+ T lymphocyte population is an integral component in the pathogenesis of SjS, recent studies have focused on the importance the B lymphocyte plays in both the pre-clinical and clinical phases of the disease process. To understand the molecular and cellular mechanisms involved in SjS, numerous mouse models that mimic major clinical manifestations of the human disease have been developed. Studies have begun to define the genetics, the nature of the autoimmune response towards the salivary and lacrimal glands, as well as the possible mechanisms for effecting glandular dysfunction, thereby establishing insights to new intervention therapies. Not surprising, the B cell is taking center stage. Here, we present an in-depth discussion of how B cell populations may be involved in orchestrating or determining exocrine gland dysfunction.

show abstract

Detection of anti-type VII collagen antibody in Sjögren's syndrome/lupus erythematosus overlap syndrome with transient bullous systemic lupus erythematosus

Cited by 20 publications

References 14 publications

Bullous Systemic Lupus Erythematosus as an Initial Manifestation of SLE

Bullous Systemic Lupus Erythematosus as an Initial Manifestation of SLE

Detection of Type VII Collagen Autoantibodies Before the Onset of Bullous Systemic Lupus Erythematosus

Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies

Contact Info

Product

Resources

About