Detection of antizona pellucida antibodies in the sera from premature ovarian failure patients by a highly specific test

Takamizawa, Satoru; Shibahara, Hiroaki; Shibayama, Tamaho; Suzuki, Michitaka

doi:10.1016/j.fertnstert.2006.12.029

Cited by 22 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study conducted in animals has demonstrated that the ZP antibodies interfere with follicular development, and the presence of these antibodies can lead to follicular depletion and amenorrhea. 22 In this study, the AZPAb was analyzed 1 week after pZP3 with FIA immunization. As shown in Table 1, mice in control group with AZPAb(þ) accounted for approximately 12.50%, while in pZP3 treatment group it was 81.25%.…”

Section: Detection Of Azpab Following Pzp3 Treatmentmentioning

confidence: 99%

Restoring Ovarian Function With Human Placenta-Derived Mesenchymal Stem Cells in Autoimmune-Induced Premature Ovarian Failure Mice Mediated by Treg Cells and Associated Cytokines

et al. 2018

View full text Add to dashboard Cite

Regulatory T (Treg) cells play a key role in the regulation of autoimmunity and transplantation. Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has a potential to restore ovarian dysfunction associated with premature ovarian failure (POF), while the exact function of the Treg cells in the transplantation still needs to be further investigated. In this study, hPMSCs were intravenously injected into POF mice following zona pellucida glycoprotein 3 (pZP3) treatment. Ovarian function was measured by analyzing estrous cycle, folliculogenesis, and hormone secretion, also, with the detection of apoptotic granular cells (GCs) in ovarian tissues. To determine whether immune response is involved in the regulation of ovarian function change, the population of Treg cell populations and expression of associated cytokines, for example, transforming growth factor β (TGF-β) and interferon γ (IFN-γ) were measured. After hPMSCs transplantation, the injured ovarian function is significantly improved. Also, the pZP3-treatment-induced apoptotic GCs were significantly decreased as compared with the POF mice. The transplantation of hPMSCs significantly increased the population of Treg cells which was inhibited by pZP3 treatment. The decrease in TGF-β and increase in IFN-γ in serum caused by pZP3 treatment have been reversed following hPMSCs transplantation. These findings strongly suggest that the recovery of ovarian function in POF mice is mediated via the regulation of Treg cells and production of associated cytokines following hPMSCs transplantation.

show abstract

Section: Detection Of Azpab Following Pzp3 Treatmentmentioning

confidence: 99%

Restoring Ovarian Function With Human Placenta-Derived Mesenchymal Stem Cells in Autoimmune-Induced Premature Ovarian Failure Mice Mediated by Treg Cells and Associated Cytokines

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The presence of anti‐autoantibodies can induce the activation of autoimmune T cell response and lead to severe organ failure (Luo et al, ). In addition, anti‐ZP antibody (AZPAb) is involved in follicular development and may be one of the causes of autoimmune POF (Takamizawa et al, ). Therefore, we used the expression of serum AZPAb as an indicator for screening POF mice.…”

Section: Discussionmentioning

confidence: 99%

Human placenta‐derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1α pathway in autoimmune POF mice

Zhao

Wang

et al. 2019

Cell Biology International

View full text Add to dashboard Cite

Previous studies have shown that the ovarian failure in autoimmune‐induced premature ovarian failure (POF) mice could be improved by the transplantation of human placenta‐derived mesenchymal stem cells (hPMSCs); however, the protective mechanism of hPMSCs transplantation on ovarian dysfunction remains unclear. Ovarian dysfunction is closely related to the apoptosis of granulosa cells (GCs). To determine the effects of hPMSCs transplantation on GCs apoptosis, an autoimmune POF mice model was established with zona pellucida glycoprotein 3 (ZP3) peptide. It is reported that the inositol‐requiring enzyme 1α (IRE1α) and its downstream molecules play a central role in the endoplasmic reticulum (ER) stress‐induced apoptosis pathway. So the aim of this study is to investigate whether hPMSCs transplantation attenuated GCs apoptosis via inhibiting ER stress IRE1α signaling pathway. The ovarian dysfunction, follicular dysplasia, and GCs apoptosis were observed in the POF mice. And the IRE1α pathway was activated in ovaries of POF mice, as demonstrated by, increased X‐box binding protein 1 (XBP1), up‐regulated 78 kDa glucose‐regulated protein (GRP78) and caspase‐12. Following transplantation of hPMSCs, the ovarian structure and function were significantly improved in POF mice. In addition, the GCs apoptosis was obviously attenuated and IRE1α pathway was significantly inhibited. Transplantation of hPMSCs suppressed GCs apoptosis‐induced by ER stress IRE1α signaling pathway in POF mice, which might contribute to the hPMSCs transplantation‐mediating ovarian function recovery.

show abstract

“…For another human ZP-based assay, Takamizawa et al [31] developed a dot-immunoassay using solubilized human ZP. The prevalence of anti-ZP antibodies in the sera was not significantly higher in women with unexplained infertility compared with other parameters.…”

Section: Current Relationship Between Anti-zp Antibodies and Infertilitymentioning

confidence: 99%

“…The prevalence of anti-ZP antibodies in the sera was not significantly higher in women with unexplained infertility compared with other parameters. However, the frequency was particularly higher in women with premature ovarian failure (POF) [31][32][33]. Indeed, there have been reports that POF was associated with elevated levels of anti-ZP antibodies [34,35].…”

Section: Current Relationship Between Anti-zp Antibodies and Infertilitymentioning

confidence: 99%

Infertility and Immunocontraception based on zona pellucida

Hasegawa

Tanaka

Shibahara

2013

Reprod Medicine & Biology

Self Cite

View full text Add to dashboard Cite

The zona pellucida (ZP) is an extracellular matrix surrounding ovarian oocytes, ovulated eggs and preimplantation embryos. It plays several important roles at different stages of reproduction. Its constituent glycoproteins are expressed specifically in the ovary. It is thus possible to produce autoantibodies to ZP proteins that interfere with reproductive functions including folliculogenesis, fertilization and implantation. First, this article describes the history of anti-ZP antibodies detected in women with idiopathic infertility. Second, the current relationship between anti-ZP antibodies and infertility is discussed in relation to assisted reproductive medicine. Third, we introduce the latest studies of animal experiments involving the ZP. Finally, immunocontraceptive vaccine development using various ZP antigens is reviewed.

show abstract

Detection of antizona pellucida antibodies in the sera from premature ovarian failure patients by a highly specific test

Cited by 22 publications

References 34 publications

Restoring Ovarian Function With Human Placenta-Derived Mesenchymal Stem Cells in Autoimmune-Induced Premature Ovarian Failure Mice Mediated by Treg Cells and Associated Cytokines

Restoring Ovarian Function With Human Placenta-Derived Mesenchymal Stem Cells in Autoimmune-Induced Premature Ovarian Failure Mice Mediated by Treg Cells and Associated Cytokines

Human placenta‐derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1α pathway in autoimmune POF mice

Infertility and Immunocontraception based on zona pellucida

Contact Info

Product

Resources

About