Detection of aspartame via microsphere-patterned and molecularly imprinted polymer arrays

Tiu, Brylee David B.; Pernites, Roderick B.; Tiu, Sicily B.; Advincula, Rigoberto C.

doi:10.1016/j.colsurfa.2016.01.038

Cited by 31 publications

(14 citation statements)

References 41 publications

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“…The charge transfer between the electrode substrate and the analyte that occupies the molecular cavities of the MIP is assured by incorporating ECP matrices in the film. Several research works in the literature report the use of electroactive monomers like 3,4-ethylenedioxythiophene (EDOT) [97,98,99], pyrrole [100,101,102,103], aniline [104,105], thiophene [106,107], and dopamine [108,109] for MIP electrosynthesis of organic compounds (Figure 5). …”

Section: Imprinting Technologymentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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Biosensors are a promising tool offering the possibility of low cost and fast analytical screening in point-of-care diagnostics and for on-site detection in the field. Most biosensors in routine use ensure their selectivity/specificity by including natural receptors as biorecognition element. These materials are however too expensive and hard to obtain for every biochemical molecule of interest in environmental and clinical practice. Molecularly imprinted polymers have emerged through time as an alternative to natural antibodies in biosensors. In theory, these materials are stable and robust, presenting much higher capacity to resist to harsher conditions of pH, temperature, pressure or organic solvents. In addition, these synthetic materials are much cheaper than their natural counterparts while offering equivalent affinity and sensitivity in the molecular recognition of the target analyte. Imprinting technology and biosensors have met quite recently, relying mostly on electrochemical detection and enabling a direct reading of different analytes, while promoting significant advances in various fields of use. Thus, this review encompasses such developments and describes a general overview for building promising biomimetic materials as biorecognition elements in electrochemical sensors. It includes different molecular imprinting strategies such as the choice of polymer material, imprinting methodology and assembly on the transduction platform. Their interface with the most recent nanostructured supports acting as standard conductive materials within electrochemical biomimetic sensors is pointed out.

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Section: Imprinting Technologymentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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“…An approach in determining the presence of the PPC is through Job's plot titration studies by varying the composition ratios of the monomer, cross‐linker, and template. On the other hand, theoretical molecular modeling is another effective protocol wherein the enthalpy requirements of the complex formation can be determined and optimized as a function of composition ratios …”

Section: Resultsmentioning

confidence: 99%

Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly(p‐aminostyrene) Films

Vergara

Pernites

Tiu

et al. 2016

Macro Chemistry & Physics

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Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine‐specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20–40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical‐quartz crystal microbalance and characterized by X‐ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen‐bonding interactions between the monomer, cross‐linker, and analyte form a stable pre‐polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte.

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“…Therefore, there is increasing interest in engaging electropolymerization in the preparation of MIP films, both conducting and nonconducting [14,15]. For this purpose, MIP films are deposited from solutions containing functional monomers (e.g., monomers 3-11 with embedded electropolymerizable moieties and functional [ 5 0 _ T D $ D I F F ] carboxy, amine, or hydroxy groups), template molecules, and suitable cross-linking monomers [16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: How Do Mips Mimic Biological Systems?mentioning

confidence: 99%