Detection of association between periodontitis and polymorphisms of IL‐1β + 3954 and TNF‐α ‐863 in the Korean population after controlling for confounding risk factors

Kim, Hyun‐Joo; Kim, Eun‐Hye; Park, Ae Kyung; Shin, Yerang; Kang, JiHoon; Lim, Jae-Sung; Bhak, Jong; Lee, Ju Youn; Kim, Byung Chul; Joo, Ji-Young

doi:10.1111/jre.12783

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…A former study by Kim et al showed a significant odds ratio of the CT allele when comparing periodontally diseased subjects with the healthy group. The results suggested that the genetic variations of interleukin -1β are associated with an increased risk of periodontitis [ 32 ]. A study by Massamatti et al, observed a nonsignificant odds ratio of 1.3–1.8 of the CT allele change in chronic periodontitis patients when compared with aggressive periodontitis patients [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

The Expression of Allele Changes in NLRP3 (rs35829419) and IL-1β (+3954) Gene Polymorphisms in Periodontitis and Coronary Artery Disease

et al. 2021

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Background: Inflammasomes have been shown to play a pivotal role in periodontal disease pathogenesis. However, their role in periodontitis subjects with coronary heart disease remains unclear. This study aimed to obtain the expression of NLRP3 (rs35829419) and IL-1β (+3954) gene polymorphisms in the subgingival plaque and blood samples of generalized periodontitis (GP) subjects with and without coronary heart disease (CHD). Methods: A total of 70 subjects were grouped into two; GP and GP with CHD. Demographic variables and periodontal and cardiac parameters were recorded from both the groups. Subgingival plaque and blood samples were obtained from both the groups and were further subjected to the identification of NLRP3 (rs35829419) and IL-1β (+3954) expression and allele change using a conventional polymerase chain reaction (PCR) and gene sequencing (Sanger’s method). Results: Amongst the demographic variables, age and monthly income were statistically significant between the two groups. Plaque index (PI), clinical attachment level (CAL), high-density lipoprotein (HDL), and low density-lipoprotein (LDL) exhibited statistically significant levels between the two groups. The NLRP3 (rs35829419) and IL-1β (+3954) genes showed a statistically significant association with allele change (frequency) among the groups. The general comparison of all the parameters with the allele change of NLRP3 (rs35829419) and IL-1β (+3954) in the subgingival plaque and blood samples showed statistically significant associations among the two groups. Conclusion: The present study highlighted an allele change in IL-1β (+3954) gene polymorphisms which may play an important role in the pathogenesis of periodontitis and coronary heart disease.

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Section: Discussionmentioning

confidence: 99%

The Expression of Allele Changes in NLRP3 (rs35829419) and IL-1β (+3954) Gene Polymorphisms in Periodontitis and Coronary Artery Disease

et al. 2021

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“…It stimulates Mø and fibroblasts to secrete PGE2, determining bone destruction [ 90 ] and fibroblasts, and Mø releases Metalloproteinases (MMPs), determining connective tissue destruction. Genetic variations of IL-1β + 3954 appear to be associated with increased risk of periodontitis in Koreans (Detection of association between periodontitis and polymorphisms of IL-1beta + 3954 and TNF-alpha −863 in the Korean population after controlling for confounding risk factors) [ 91 ]. For IL-1β, the sensitivity ranged from 54% to 88% and specificity ranged from 52% to 100% across five studies [ 31 , 84 , 85 , 92 , 93 ].…”

Section: The Most Promising Host Derived Biomarkers As Candidates mentioning

confidence: 99%

Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

Cafiero

Spagnuolo

Marenzi

et al. 2021

JCM

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The primary cause of tooth loss in the industrialized world is periodontitis, a bacterial anaerobic infection whose pathogenesis is characterized by composite immune response. At present, the diagnose of periodontitis is made by a complete status check of the patient’s periodontal health; full-mouth plaque score, full-mouth bleeding score, probing depth, clinical attachment level, bleeding on probing, recessions, mobility, and migration are evaluated in order to provides a clear picture of the periodontal conditions of a single patient. Chair-side diagnostic tests based on whole saliva could be routinely used by periodontists for a very early diagnosis of periodontitis, monitoring, prognosis, and management of periodontal patients by biomarker detection, whose diagnostic validity is related to sensitivity and specificity. Recent paper reviews and meta-analyses have focused on five promising host derived biomarkers as candidate for early diagnosis of periodontitis: MMP-8 (Metalloproteinase-8), MIP-1α (Macrophage inflammatory protein-1 alpha), IL-1 β (Interleukin-1 beta), IL-6 (Interleukin-6), and HB (Hemoglobin), and their combinations. Chair-side Lab-on-a-chip (LOC) technology may soon become an important part of efforts to detect such biomarkers in saliva medium to improve worldwide periodontal health in developed nations as well as in underserved communities and poor countries. Their applications in preventive and predictive medicine is now fundamental, and is aimed at the early detection of risk factors or the presence or evolution of the disease, and in personalized medicine, which aims to identify tailor-made treatments for individual patients. The aim of the present paper is to be informative about host derived periodontal biomarkers and, in particular, we intend to report information about the most important immune response derived biomarkers and Hemoglobin as candidates to be routinely utilized in order to obtain a chair-side early diagnosis of periodontal disease.

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“…23 Numerous evidence has suggested that TNF-α plays an important role in periodontitis since it induces the occurrence and development of periodontitis while affecting the repair of periodontal tissue. 24 However, there are controversial research results regarding the intervention and treatment of periodontitis with TNF-α. Xiao et al's 25 study asserted that the level of TNF-α in the site of periodontitis significantly decreased.…”

Section: Discussionmentioning

confidence: 99%

“…It stimulates prostaglandin synthesis, promotes various swelling, produces protease, activates osteoclast resorption, inhibits osteoblast proliferation and matrix synthesis, and activates TNF receptor related factor‐2 to destroy bone homeostasis, leading to the activation of NF‐KB, AP‐1, and MAPKs signaling pathways, thereby affecting bone formation 23 . Numerous evidence has suggested that TNF‐α plays an important role in periodontitis since it induces the occurrence and development of periodontitis while affecting the repair of periodontal tissue 24 . However, there are controversial research results regarding the intervention and treatment of periodontitis with TNF‐α.…”

Section: Discussionmentioning

confidence: 99%

Expression of TNF‐α, omentin‐1, and IL‐6 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel

Zhang,

Wang,

Liu

2024

J Oral Pathology Medicine

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BackgroundThe objective of this study was to evaluate and compare the expression levels of TNF‐α, omentin‐1, and IL‐6 in periodontitis patients before and after treatment with biological antimicrobial peptide (AMP) periodontal gel.MethodsThere involved 86 periodontitis patients admitted to our hospital from January 2020 to March 2021. They were equally and randomly distributed into the study group and the control group. The efficacy and adverse reactions were compared between the two groups after treatment, Additionally, the sulcus bleeding index (SBI), plaque index (PLI), gingival index (GI), periodontal probing depth (PD), and levels of TNF‐α, omentin‐1, and IL‐6 were measured before and after treatment.ResultsAfter treatment, the total effective rate of the study group was significantly higher than that of the control group (p < 0.05), while the scores of four indicators (SBI, PLI, GI, and PD) and the levels of TNF‐α, omentin‐1, and IL‐6 in the study group were evidently lower than the control group (p < 0.05). The study group had 1 case of mild irritant reaction, with an adverse reaction rate of 2.33% (1/43). And the control group had 1 case of nausea and 1 case of allergy, with an adverse reaction rate of 4.65% (2/43). The adverse reactions demonstrated no statistical difference between the two groups (χ2 = 0.345, p = 0.557).ConclusionsThe levels of TNF‐α and IL‐6 were highly expressed before the auxiliary therapy of biological AMP periodontal gel for periodontitis, alongside low expression of omentin‐1. Subsequently, the biological antibacterial polypeptide periodontal gel demonstrated efficacy in the treatment of periodontitis.

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Detection of association between periodontitis and polymorphisms of IL‐1β + 3954 and TNF‐α ‐863 in the Korean population after controlling for confounding risk factors

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 8 publications

References 49 publications

The Expression of Allele Changes in NLRP3 (rs35829419) and IL-1β (+3954) Gene Polymorphisms in Periodontitis and Coronary Artery Disease

The Expression of Allele Changes in NLRP3 (rs35829419) and IL-1β (+3954) Gene Polymorphisms in Periodontitis and Coronary Artery Disease

Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

Expression of TNF‐α, omentin‐1, and IL‐6 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel

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