Detection of bacterial metabolites for the discrimination of bacteria utilizing gold nanoparticle chemiresistor sensors

Webster, Melissa S.; Cooper, James S.; Chow, Edith; Hubble, Lee J.; Sosa-Pintos, Andrea; Wieczorek, Lech; Raguse, Burkhard

doi:10.1016/j.snb.2015.06.024

Cited by 24 publications

(15 citation statements)

References 44 publications

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“…Reproduced with permission. [112] Copyright 2015, Elsevier. The advantage of array-based sensors over traditional singlecomponent sensors is that they are capable of discriminating a variety of targets spontaneously, enabling the multiplexed bacteria detection traditionally limited by the "lock-and-key" sensing strategy.…”

Section: Discussionmentioning

confidence: 99%

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Array‐Based Biosensors for Bacteria Detection: From the Perspective of Recognition

Xianyu

2021

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Array‐based biosensors have shown as effective and powerful tools to distinguish intricate mixtures with infinitesimal differences among analytes such as nucleic acids, proteins, microorganisms, and other biomolecules. In array‐based bacterial sensing, the recognition of bacteria is the initial step that can crucially influence the analytical performance of a biosensor array. Bacteria recognition as well as the signal readout and mathematical analysis are indispensable to ensure the discrimination ability of array‐based biosensors. Strategies for bacteria recognition mainly include the specific interaction between biomolecules and the corresponding receptors on bacteria, the noncovalent interaction between materials and bacteria, and the specific targeting of bacterial metabolites. In this review, recent advances in array‐based bacteria sensors are discussed from the perspective of bacteria recognition relying on the characteristics of different bacteria. Principles of bacteria recognition and signal readout for bacteria detection are highlighted as well as the discussion on future trends in array‐based biosensors.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Array‐Based Biosensors for Bacteria Detection: From the Perspective of Recognition

Xianyu

2021

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“…Using the Au@MNP sensing system, Gooding and co-workers 86 described a new class of biosensor, referred to as biochemiresistor, which is made possible by the ability to magnetically assemble the nanoparticles, when desired, as a film across two electrodes. The biochemiresistor is a variant of the solution phase chemiresistor, 87,88 but where changes in resistance across a nanoparticle film are measured as a consequence of changes in the amount of biological molecules that bind to the nanoparticles. 86 The Gooding group demonstrated the principle through the detection of small organic molecules.…”

Section: Au@mnps Incorporated Electrochemical Sensorsmentioning

confidence: 99%

Gold coated magnetic nanoparticles: from preparation to surface modification for analytical and biomedical applications

et al. 2016

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Gold coated magnetic nanoparticles (Au@MNPs) have become increasingly interesting to nanomaterial scientists due to their multifunctional properties and their potential in both analytical chemistry and nanomedicine. The past decade has seen significant progress in the synthesis and surface modification of Au@MNPs. This progress is based on advances in the preparation and characterization of iron/iron oxide nanocrystals with the required surface functional groups. In this critical review, we summarize recent developments in the methods of preparing Au@MNPs, surface functionalization and their application in analytical sensing and biomedicine. We highlight some of the remaining major challenges, as well as the lessons learnt when working with Au@MNPs.

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“…Chemiresistors (CRs) [ 11 ] are a compelling alternative which possess considerable advantages for POC applications, including excellent sensitivity, cost‐effectiveness, simple sensing mechanism, [ 12 ] portability, [ 13 ] facile integration into microfluidic systems, [ 14 ] and combination with optoelectronic transducers. [ 15 ]…”

Section: Introductionmentioning

confidence: 99%

“…Chemiresistors (CRs) [11] are a compelling alternative which possess considerable advan tages for POC applications, including excellent sensitivity, costeffectiveness, simple sensing mechanism, [12] port ability, [13] facile integration into microfluidic systems, [14] and combination with optoelectronic transducers. [15] Noble metal nanoparticles (NPs) are ideal scaffolds for the fabrication of different types of sensing devices, [16] especially CRs, [12,17] due to their high surfacetovolume ratio and unique optical and electrical properties, which are very sensitive to chemical events occurring in their surroundings. According to the Kubo model, [18] Au NPs having a diameter exceeding ≈2 nm behave as nanoscopic electrical conductors obeying Ohm's law.…”

Section: Introductionmentioning

confidence: 99%

Harnessing Selectivity and Sensitivity in Ion Sensing via Supramolecular Recognition: A 3D Hybrid Gold Nanoparticle Network Chemiresistor

Oliveira

Wang

Berezin

et al. 2020

Adv Funct Materials

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The monitoring of K + in saliva, blood, urine, or sweat represents a future powerful alternative diagnostic tool to prevent various diseases. However, several K + sensors are unable to meet the requirements for the development of point-of-care (POC) sensors. To tackle this grand-challenge, the fabrication of chemiresistors (CRs) based on 3D networks of Au nanoparticles covalently bridged by ad-hoc supramolecular receptors for K + , namely dithiomethylene dibenzo-18-crown-6 ether is reported here. A multi-technique characterization allows optimizing a new protocol for fabricating high-performing CRs for real-time monitoring of K + in complex aqueous environments. The sensor shows exceptional figures of merit: i) linear sensitivity in the 10-3 to 10-6 m concentration range; ii) high selectivity to K + in presence of interfering cations (Na + , Ca 2+ , and Mg 2+); iii) high shelf-life stability (>45 days); iv) reversibility of K + binding and release; v) successful device integration into microfluidic systems for real-time monitoring; vi) fast response and recovery times (<18 s), and v) K + detection in artificial saliva. All these characteristics make the supramolecular CRs a potential tool for future applications as POC devices, especially for health monitoring where the determination of K + in saliva is pivotal for the early diagnosis of diseases.

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Detection of bacterial metabolites for the discrimination of bacteria utilizing gold nanoparticle chemiresistor sensors

Cited by 24 publications

References 44 publications

Array‐Based Biosensors for Bacteria Detection: From the Perspective of Recognition

Array‐Based Biosensors for Bacteria Detection: From the Perspective of Recognition

Gold coated magnetic nanoparticles: from preparation to surface modification for analytical and biomedical applications

Harnessing Selectivity and Sensitivity in Ion Sensing via Supramolecular Recognition: A 3D Hybrid Gold Nanoparticle Network Chemiresistor

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