2012
DOI: 10.1016/j.bjid.2012.10.003
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Detection of blaOXA-23 in Acinetobacter spp. isolated from patients of a university hospital

Abstract: OXA-23-like enzymes may be an important mechanism of carbapenem resistance among isolates present in the hospital studied.

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Cited by 22 publications
(20 citation statements)
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“…As long as therapeutic options for treating multidrug-resistant Acinetobacter spp. strains are quite limited, our results support the effectiveness of polymyxin B and tigecycline [37][38][39].…”
Section: Discussionsupporting
confidence: 81%
See 1 more Smart Citation
“…As long as therapeutic options for treating multidrug-resistant Acinetobacter spp. strains are quite limited, our results support the effectiveness of polymyxin B and tigecycline [37][38][39].…”
Section: Discussionsupporting
confidence: 81%
“…Data from a national study carried out by others also corroborate these findings [38]. However, these data revealed a high frequency of isolates that were sensitive to tetracycline (approximately 85%), which were different from our results (44.4%).…”
Section: Discussionsupporting
confidence: 56%
“…Karbapenemi hidrolize eden ilk oksasilinaz olarak, 1985 yılında İngiltere'de tanımlanan OXA-23 enzimi, daha sonra hızla yayılmış ve OXA-23-benzeri enzimleri üreten izolatlar Avrupa, Asya ve Güney Amerika'da birçok merkezden bildirilmiştir [11][12][13][14][15] . Bizim çalışmamızda da, incelenen tüm suşlarda bla OXA-23 geninin varlığı saptanmış; bu durum hastanemizde OXA-23-benzeri enzimlerin karbapenem direncinden sorumlu önemli mekanizmalardan biri olduğunu düşündürmüştür.…”
Section: Discussionunclassified
“…A similar report by Liakopoulos et al, [19] in Greece, noted that 120 out of 127 (95 %) A. baumannii isolates collected in 2011 were bla OXA-23 positive. Oxacillinase encoding gene bla OXA-23 was also reported as the most common carbapenamase encoding gene among Acinetobacter spp by Corrêa et al, [20] in Brazil and Santimaleeworagun et al, [15] in Thailand. It has been associated with resistance to carbapenems [21].…”
Section: Discussionmentioning
confidence: 99%