Detection of bone marrow abnormalities in patients with Hodgkin's disease by T1 mapping of MR images of lumbar vertebral bone marrow

Smith, S. R.; Roberts, Neil; Percy, David F.; Edwards, R. H. T.

doi:10.1038/bjc.1992.49

Cited by 23 publications

(9 citation statements)

References 11 publications

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“…In conclusion, our data indicate that independent of the mechanism of action, successful chemotherapy causes a decrease in tumor T 1 , which most likely reflects the number of viable cells in a solid tumor. A decrease in the T 1 of cancers has been shown following successful therapy with radiation and various types of cytotoxic chemotherapy (26)(27)(28)(29), but has not been routinely applied. We believe that application of the IR TrueFISP method for measuring tumor T 1 will provide a fully quantitative noninvasive method that does not require injection of a tracer or CA or complex modeling, yet provides a rapid read-out of cell viability in the target tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Animals treated with chemotherapy or radiotherapy showed increases (22)(23)(24) and decreases (15,25) in tumor T 1 . However, in four different quantitative T 1 studies in the clinic, only decreases were detected in response to successful therapy with radiation or cytotoxics (26)(27)(28)(29). Using eight different experimental tumor models, we show that T 1 can be measured easily with minimal variation and does not change with tumor size.…”

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confidence: 89%

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Quantified Tumor T1 Is a Generic Early-Response Imaging Biomarker for Chemotherapy Reflecting Cell Viability

McSheehy

Weidensteiner

Cannet

et al. 2010

Clinical Cancer Research

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Purpose: Identification of a generic response biomarker by comparison of chemotherapeutics with different action mechanisms on several noninvasive biomarkers in experimental tumor models.Experimental Design: The spin-lattice relaxation time of water protons (T 1 ) was quantified using an inversion recovery-TrueFISP magnetic resonance imaging method in eight different experimental tumor models before and after treatment at several different time points with five different chemotherapeutics. Effects on T 1 were compared with other minimally invasive biomarkers including vascular parameters, apparent diffusion coefficient, and interstitial fluid pressure, and were correlated with efficacy at the endpoint and histologic parameters.Results: In all cases, successful chemotherapy significantly lowered tumor T 1 compared with vehicle and the fractional change in T 1 (ΔT 1 ) correlated with the eventual change in tumor size (range: r 2 = 0.21, P < 0.05 to r 2 = 0.73, P < 0.0001), except for models specifically resistant to that drug. In RIF-1 tumors, interstitial fluid pressure was decreased, but apparent diffusion coefficient and permeability increased in response to the microtubule stabilizer patupilone and 5-fluorouracil. Although ΔT 1 was small (maximum of −20%), the variability was very low (5%) compared with other magnetic resonance imaging methods (24-48%). Analyses ex vivo showed unchanged necrosis, increased apoptosis, and decreased %Ki67 and total choline, but only Ki67 and choline correlated with ΔT 1 . Correlation of Ki67 and ΔT 1 were observed in other models using patupilone, paclitaxel, a VEGF-R inhibitor, and the mammalian target of rapamycin inhibitor everolimus. Conclusions: These results suggest that a decrease in tumor T 1 reflects hypocellularity and is a generic marker of response. The speed and robustness of the method should facilitate its use in clinical trials. Clin Cancer Res; 16(1); 212-25. ©2010 AACR.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 89%

Quantified Tumor T1 Is a Generic Early-Response Imaging Biomarker for Chemotherapy Reflecting Cell Viability

McSheehy

Weidensteiner

Cannet

et al. 2010

Clinical Cancer Research

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“…As a guide for bone marrow biopsies, it can depict areas of marrow involvement accurately. 23 Furthermore, the greater sensitivity, which was a significant 90% in the study, combined with good image resolution, speed and the lack of ionising radiation makes this modality better suited for repeated studies of bone marrow changes in all age groups, with only very few absolute contraindications. The goal of an imaging test for screening purposes must, in this author's opinion, be to provide the most accurate result achieved within a reasonable timeframe and with the least possible discomfort to the patient.…”

Section: Resultsmentioning

confidence: 99%

The use of whole body magnetic resonance imaging in detecting bone marrow disorders – a valid alternative to imaging modalities that utilise ionising radiation

Hansen¹

2005

Radiographer

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Imaging modalities for investigation of bone marrow abnormalities have traditionally involved the use of ionising radiation. Now magnetic resonance imaging (MRI) offers an alternative to x-rays, computer tomography (CT), nuclear medicine bone scans and bone mineral densitometry. This study attempts to evaluate the sensitivity and specificity of whole body MRI in detecting bone marrow abnormalities, using T1 and short tau inversion recovery (STIR) weighted sequences. This was achieved by reviewing already acquired scan data to discover whether this method is more sensitive to marrow changes than conventional radiographic skeletal surveys and other imaging tests, involving ionising radiation.The study involved 10 adult participants all of whom suffered from heamatological malignancies, including multiple myeloma, plasma cell dyscrasia, non-Hodgkin's lymphoma and acute lymphocytic leukaemia. Most of the study group presented with multiple myeloma. Abnormal skeletal MRI findings were reported in nine out of the 10 participants, i.e., a positive detection rate of 90%, using whole body MRI. All participants in the study who suffered from multiple myeloma or plasma cell dyscrasia showed positive MRI findings regardless of the stage of their disease. Four already had a confirmed diagnosis prior to the MRI scan, which was either visible on x-ray or bone scintigraphy. Three participants had positive serum/urine tests, but negative radiographic findings. The study therefore established that, when investigating possible marrow disorders, MRI was more sensitive to changes in the bone-marrow producing part of the skeleton and that MRI therefore must be considered a more suitable imaging tool.

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“…Roberts et al have reported the use of pixel by pixel mapping of lumbar vertebral T x and have displayed the data in histogram form [4]. This technique has been extended to a study of Hodgkin's disease to study the effects of treatment on the spatial distribution of abnormal areas within the vertebral bodies [5]. We have adopted a similar approach, acquiring relaxation time maps and histograms showing the distribution of relaxation times in a preliminary study of long-term changes in bone marrow following TBI and allogenic BMT (ABMT).…”

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confidence: 98%

MRI in the evaluation of late bone marrow changes following bone marrow transplantation

Tanner

Clarke²,

Leach³

et al. 1996

The British Journal of Radiology

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Measurements of MR spin-lattice (T1), and spin-spin (T2) relaxation times in lumbar vertebrae have been performed in a pilot study on six adult patients, treated for acute myeloid leukaemia (AML). All patients were treated with initial chemotherapy and then proceeded to bone marrow transplantation (BMT), conditioned with Melphalan and total body irradiation (TBI). MR measurements were made between 21 and 89 months after TBI. The relaxation times in the six patients were compared with those in six healthy age-matched volunteers to establish whether there were differences between the two groups. Average T1 values in the vertebrae of the treated patients are significantly shorter (p < 0.01) than in the healthy volunteers. This is consistent with the observation of a relatively hyperintense vertebral bone marrow in the T1 weighted images and is likely to be a consequence of treatment induced fatty replacement of marrow. Shorter T1 values tend to be distributed within the centre of the lumbar vertebrae compatible with observations, made by others, which suggest that the peripheral zone of the vertebral body has been repopulated with bone marrow cells whereas the central zone, around the basivertebral vein, is predominantly fat. Histogram displays of vertebral body relaxation time distributions (T1, T2) for both patients and healthy age-matched volunteers are similar in that both patients and volunteers give histograms that are only slightly skewed. This similarity is probably a reflection of the fact that the patients have been in remission for over a year and have generally healthy bone marrow.

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Detection of bone marrow abnormalities in patients with Hodgkin's disease by T1 mapping of MR images of lumbar vertebral bone marrow

Cited by 23 publications

References 11 publications

Quantified Tumor T1 Is a Generic Early-Response Imaging Biomarker for Chemotherapy Reflecting Cell Viability

Quantified Tumor T1 Is a Generic Early-Response Imaging Biomarker for Chemotherapy Reflecting Cell Viability

The use of whole body magnetic resonance imaging in detecting bone marrow disorders – a valid alternative to imaging modalities that utilise ionising radiation

MRI in the evaluation of late bone marrow changes following bone marrow transplantation

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