Detection of Cancer Metastases with a Dual-labeled Near-Infrared/Position Emission Tomography Imaging Agent

Sampath, Lakshmi; Kwon, Sunkuk; Hall, Mary; Price, Roger E.; Sevick‐Muraca, Eva M.

doi:10.1593/tlo.10139

Cited by 71 publications

(62 citation statements)

References 52 publications

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“…Lymph node involvement is primarily regional in cancers of the internal organs, including lung cancer (4,7). Therefore, common sites of lymph node metastasis in lung cancer are the hilar, mediastinal and supraclavicular nodes.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer with spontaneous regression of primary and metastatic sites: A case report

Ogawa¹,

Watanabe²,

Yazaki³

et al. 2015

Oncology Letters

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Abstract. Partial or complete spontaneous cancer regression is a rare phenomenon, particularly in patients with lung cancer. This is the case report of a patient with lung cancer who exhibited spontaneous regression of the primary as well as metastatic lesions, without receiving any treatment. Spontaneous regression commenced within a week of obtaining pathological specimens by transbronchial and percutaneous biopsies from the primary lesion and metastatic lymph nodes of the left side of the neck. The reason for this phenomenon is unknown; however, we hypothesized that there may be an immunological association between the stimulus of the biopsies and the spontaneous regression. This patient should be closely followed up to monitor the clinical course of this unusual case.

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Section: Discussionmentioning

confidence: 99%

Lung cancer with spontaneous regression of primary and metastatic sites: A case report

Ogawa¹,

Watanabe²,

Yazaki³

et al. 2015

Oncology Letters

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“…Namely, the judgment is expected to be given based on the biomedical or functional information shown in the early stage of breast cancer. 1,5 Near-infrared Spectroscopy (NIRS) coincides with this trend, which exploits the principle that biological tissue, to some extent, can absorb and scatter light. On the basis of intensities of input and output light, the quantitative information of the content that may absorb or scatter light will be achieved.…”

Section: Introductionmentioning

confidence: 90%

Tissue phantom-based breast cancer detection using continuous near-infrared sensor

et al. 2016

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Women's health is seriously threatened by breast cancer. Taking advantage of efficient diagnostic instruments to identify the disease is very meaningful in prolonging life. As a cheap noninvasive radiation-free technology, Near-infrared Spectroscopy is suitable for general breast cancer examination. A discrimination method of breast cancer is presented using the deference between absorption coefficients and applied to construct a blood oxygen detection device based on Modified Lambert-Beer theory. Combined with multi-wavelength multi-path near-infrared sensing technology, the proposed method can quantitatively distinguish the normal breast from the abnormal one by measuring the absorption coefficients of breast tissue and the blood oxygen saturation. An objective judgment about the breast tumor is made according to its high absorption of near-infrared light. The phantom experiment is implemented to show the presented method is able to recognize the absorption differences between phantoms and demonstrates its feasibility in the breast tumor detection.

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“…Ex vivo NIR fluorescence imaging also visualized the trafficking of imaging agent from the primary tumor to lymph nodes, which was not possible for nuclear imaging with 64 Cu. When 18 FDG was investigated, it could not detect metastases under these conditions (Sampath et al, 2010).…”

Section: Dual-labeled Trastuzumabmentioning

confidence: 97%

“…To investigate this possibility, trastuzumab was conjugated with either 111 In (for SPECT imaging) or 64 Cu (for PET imaging), and IRDye 800CW to image HER2 overexpression in mouse xenograft tumors (Sampath et al, 2010;Sampath et al, 2007).…”

Section: Dual-labeled Trastuzumabmentioning

confidence: 99%

Targeting EGFR and HER2 for Molecular Imaging of Cancer

Gong¹,

Sampath²,

Kovar³

et al. 2012

Molecular Imaging

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Detection of Cancer Metastases with a Dual-labeled Near-Infrared/Position Emission Tomography Imaging Agent

Abstract: ((64)Cu-DOTA)(n)-trastuzumab-(IRDye800)(m) may be an effective diagnostic imaging agent for staging HER-2-positive breast cancer patients and intraoperative resection.

Cited by 71 publications

References 52 publications

Lung cancer with spontaneous regression of primary and metastatic sites: A case report

Lung cancer with spontaneous regression of primary and metastatic sites: A case report

Tissue phantom-based breast cancer detection using continuous near-infrared sensor

Targeting EGFR and HER2 for Molecular Imaging of Cancer

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