Detection of Chemical Gestational Diabetes

Sutherland, H. W.; Stowers, J. M.; Fisher, Peter

doi:10.1007/978-3-642-66972-9_29

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…In the GD group, maternal pre-pregnancy weight was significantly higher in the pregnancies associated with neonatal morbidity than in the no-morbidity group; this agrees with earlier reports by O' Sullivan et aI. (1973) and Sutherland et al (1978). This is also supported by results of the discriminant analysis which show that besides gestational age at delivcry matcrnal pre-pregnancy weight was the only factor with impact o n the classification of neonatal morbidity.…”

Section: Discussionsupporting

confidence: 90%

Factors influencing neonatal morbidity in gestational diabetic pregnancy

Nordlander

Hanson

Persson

1989

BJOG

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Summary. The influence of obstetric factors and indices of maternal blood glucose control on neonatal morbidity was examined in 261 women with gestational diabetes. A reference group of 218 women, matched for age and day of delivery, within 1 week, was used for comparison. Perinatal morbidity was significantly more frequent in the gestational diabetic pregnancies (23%) than in the reference group (13%), whereas the occurrence of large‐for‐gestational‐age infants was not different between the groups. Infants born to women with gestational diabetes were categorized to a no‐morbidity group (n=200) and a morbidity group (n=61). The group with morbidity had significantly shorter gestational age at delivery, higher frequency of caesarean section, higher maternal pre‐pregnancy weight and higher area under the glucose tolerance curve. There was no significant difference in third‐trimester blood glucose between the groups. Discriminant analysis revealed that the most significant influence on neonatal morbidity was gestational age at delivery. After correction for this factor the only factor with added significance for neonatal morbidity was maternal pre‐pregnancy weight. The present study clearly illustrates that other factors beside blood glucose control are of importance for neonatal outcome in gestational diabetic pregnancy.

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Section: Discussionsupporting

confidence: 90%

Factors influencing neonatal morbidity in gestational diabetic pregnancy

Nordlander

Hanson

Persson

1989

BJOG

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“…In 9.3% of women with twin pregnancies there was a family history of diabetes in first-degree relatives, compared with 7.3% in singletons (Table 6) [15]. There was a greater tendency to obesity in the women with twin pregnancies according to Kemsley [11] scales for weight for height centiles above both the 75th and 85th.…”

Section: Resultsmentioning

confidence: 94%

“…The distribution pattern of increment index in twin and singleton pregnancies (Figure ) differ, in that there is a tendency for lower values of increment index to be found in the twin pregnancies. The singleton values were obtained from 500 consecutive glucose tolerance tests carried out recently in pregnancy in Aberdeen on the basis of indicators of potential diabetes [15].…”

Section: Resultsmentioning

confidence: 99%

Glucose Tolerance in Twin Pregnancy

Campbell

MacGillivray

1979

Acta genet. med. gemellol.: twin res.

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“…Metformin has anti-cell growth and pro-apoptotic effects; there are persistent concerns over the use of Metformin in early pregnancy (Sutherland & Stowers, 1979). It is safe in pregnancy, but crosses the placenta and may have comparable plasma concentrations in the mother and child at birth.…”

Section: Pre-concern Of Metforminmentioning

confidence: 99%

Effects of Metformin Among Type 2 Diabetes Pregnant Women: A Preliminary Study

Mohajan,

Mohajan

2023

JIMR

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Diabetes mellitus (DM) is a chronic but non-contagious metabolic disease that is characterized by elevated levels of blood sugar. In pregnancy it increases various risk factors, such as adverse maternal, fetal, obstetric, and neonatal consequences. Gestational diabetes (GD) is associated with abnormalities in placental development including impairments in trophoblastic differentiation. Insulin therapy is the best treatment for both mother and fetus. On the other hand, Metformin is an oral anti-hyperglycaemia agent that is commonly used to treat type 2 diabetes (T2D) pregnant and non-pregnant women worldwide. But its role in gestational diabetes management remains controversial. It prevents the production of hepatic glucose, increases fatty acid oxidation, enhances insulin sensitivity, decreases lipid synthesis, and impedes gluconeogenesis. From the scientific researches of scientists obtained that hypoglycaemia is not a concern of Metformin. In this review article the benefits and possible negative impacts of Metformin use during pregnancy are discussed in briefly.

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Detection of Chemical Gestational Diabetes

Cited by 9 publications

References 17 publications

Factors influencing neonatal morbidity in gestational diabetic pregnancy

Factors influencing neonatal morbidity in gestational diabetic pregnancy

Glucose Tolerance in Twin Pregnancy

Effects of Metformin Among Type 2 Diabetes Pregnant Women: A Preliminary Study

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