Detection of chemical warfare simulants by phosphorylation of a coumarin oximate

Abstract

The detection of chemical warfare simulants is attained by the PET mechanism that gives an "off-on" fluorescent response with a half-life of approximately 50 ms upon phosphorylation of a reactive oximate functionality; the X-ray crystal structure of the oximate was also obtained and is discussed.

Flower-like tungsten oxide particles: Synthesis, characterization and dimethyl methylphosphonate sensing properties

“…Some methods such as luminescence [5][6][7], electrochemistry [8] for detection of these nerve agents have been described in recent reports. However, these methods are usually limited by low sensitivity, operational complexity and non-portability.…”

Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates

“…The mode of action for these nerve agents is the inhibition of the enzyme acetylcholinesterase, which results in continuous overstimulation of muscles that can ultimately result in death. The need for proper protection against these threats has led to the development of a variety of detection schemes for CWAs over the past few decades, 1,2 including chromatographic, [3][4][5][6] spectroscopic, 7-10 electrochemical, 11-15 fluorogenic, [16][17][18][19][20][21][22][23][24][25] and colorimetric [26][27][28][29] approaches. Fewer reports can be found for polymer-based detection schemes.…”

Coumarin-Derived Fluorescent Chemosensors

“…One of the applicable technologies is the design of fluorogenic chemosensors for the specific detection of nerve agents (Royo et al, 2007). A coumarin oximate 103 has been developed for detection of chemical warfare simulants based on the PET mechanism that gives an "off-on" fluorescent response with a half-time of approximately 50 ms upon phosphorylation of a reactive oximate functionality (Wallace et al, 2006). Coumarin-derived hydroxy oxime 104 serves as a nerve agent sensor based on the reaction of -hydroxy oxime with organophosphorus agent mimics (Dale & Rebek, 2009).…”