Detection of Chrysin as Agent for potential treatment of Alzheimer's Disease using Electrochemical sensor Based on CuO@Ta2O5 nanocomposite Modified Glassy Carbon Electrode

Abstract

In this work, the CuO@Ta2O5 nanocomposite was synthesized, and the chemical stability and sensing capabilities of the CuO@Ta2O5 nanocomposite as a chrysin sensor were improved. The nanocomposite was electrodeposited on a glassy carbon electrode (GCE), and structural analyses using SEM and XRD indicated that the GCE was uniformly coated with high porosity CuO@Ta2O5 nanoparticles. The amperometry and cyclic voltammetry experiments showed the high sensitive, selective, stable and accurate response of CuO@Ta2O5/GCE to chrysin determination because of the formation of a heterointerface between CuO and Ta2O5 nanostructures, which facilitates charge migration and enhances the catalytic activity of CuO@Ta2O5/GCE. Results showed that the linear range, detection limit and sensitivity were obtained at 10 to 100µM, 0.008µM and 0.92921µA/µM, respectively. The practicality of the proposed electrochemical sensor in real samples was studied and results indicated the obtained recovery (96.00% to 98.00%) and RSD (2.77% to 3.11%) values were acceptable, illustrating that CuO@Ta2O5/GCE can be used as a practical sensor to detect chrysin in pharmaceutical and biological samples.