Detection of circulating gastric carcinoma-associated antigen MG7-Ag in human sera using an established single determinant immuno-polymerase chain reaction technique

Ren, Jun; Chen, M B Zheng; Zhou, Shao Juan; Zhang, Xue Yong; Pan, Bo; Fan, Dai Ming

doi:10.1002/(sici)1097-0142(20000115)88:2<280::aid-cncr6>3.0.co;2-7

Cited by 63 publications

(26 citation statements)

References 17 publications

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“…Serum levels of CEA and CA 19-9 exhibited no significant differences between cases of initial and advanced disease. The superiority of CA 72-4 for gastric cancer over CEA and CA has been previously demonstrated by other authors 7,22,23 . However, CA 72-4 seems to be a marker of advanced disease, rather than a marker for mass survey screening for the detection of early disease.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies of serum levels of CEA, CA 19-9, and CA 72-4 in gastric cancer have demonstrated that the positivity of these markers has a wide range of variation, from 14% to 42% for CEA 1-8, 10,20-22 , from 16% to 38.4% for CA 19-9 7,8,10,21,22 , and from 24.2% to 45.3% for CA 72-4 7,9,10,22 .…”

Section: Discussionmentioning

confidence: 99%

“…A novel sensitive method, which has been termed immuno-polymerase chain reaction (immuno-PCR), was developed for the detection of gastric carcinoma-associated antigen MG7-Ag. The comparison of immuno-PCR and commercial assays for tumor markers demonstrated that the sensitivity of immuno-PCR was 81.4% 22 .…”

Section: Discussionmentioning

confidence: 99%

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Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

et al. 2002

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INTRODUCTION: The clinical importance of preoperative serum levels of CA 72-4, carcinoembryonic antigen (CEA), CA 19-9, and alpha-fetoprotein (AFP) was prospectively evaluated in 44 patients with gastric cancer. METHOD: The serum tumor marker levels were determined by commercial radioimmunoassay kits. Positivity for CA 72-4 (>4 U/mL), CEA (>5 ng/mL), CA 19-9 (>37 U/mL), and AFP (>10 ng/mL) were correlated according to the stage, histology, and lymph node metastasis. RESULTS AND DISCUSSION: CA 72-4 showed a higher positivity rate for gastric cancer (47.7%) than CEA (25%), CA 19-9 (25%), and AFP (0%). The combination of CA 72-4 with CEA and CA 19-9 increased the sensitivity to 61.4%. The positivity rates of CA 72-4 in patients at stages I and II (initial disease) and in patients at stages III and IV (advanced disease) were 9% and 60.6%, respectively (P < 0.005). No correlation was found between CEA and CA 19-9 levels and the stage of gastric cancer. There was a tendency of positivity for CA 72-4 to suggest lymph node involvement, but it was not significant (P = 0.075). Serum levels of tumor markers did not show a correlation with the histological types of gastric cancer. CONCLUSION: Preoperative serum levels of CA 72-4 provided a predictive value in indicating advanced gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer

et al. 2002

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“…Unlike other traditional gastrointestinal tumor-associated antigens, it is high specific and sensitive for gastric cancer. The positive rates of MG7-Ag were 80% to 94% in cancer tissues and 40% to 60% in sera in the patients with gastric cancer (Ren et al, 2000). The sensitivity of the serum MG7-Ag was 81.4% for the diagnosis of gastric cancer (Ren et al, 2011).…”

Section: Gastric Cancer Antigen Mg7-ag (Mg7-ag)mentioning

confidence: 99%

Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

He¹,

Zhang²

2013

Asian Pacific Journal of Cancer Prevention

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The high incidence of gastric cancer and consequent mortality pose severe threats to human health. Early screening, diagnosis and treatment are the key to improve the prognosis of the patients with gastric cancer. Gastroscopy with biopsy is an efficient method for the diagnosis of early gastric cancer, but the associated discomfort and high cost make it difficult to be a routine method for screening gastric cancer. Serum tumor marker assay is a simple and practical method for detection of gastric cancer, but it is limited by poor sensitivity and specificity. Therefore, people have been looking for novel serum markers of gastric cancer in recent years. Here we review the novel serum tumor markers of gastric cancer and their diagnostic significance, focusing on the discoveries from serum proteomics analyses and epigenetics researches.

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“…It combines the specificity of an ELISA reaction with the sensitivity of assays that use a PCRamplification step. Since its development, the method has been applied to detect antigens associated with cancer [23,24], autoimmune diseases [25], pathogenic bacteria [26] and bacterial toxin [27]. But no environmental pollutants have been detected by IPCR.…”

Section: Introductionmentioning

confidence: 99%