Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers

Cui, Long; Lou, Yan-Ru; Zhang, Xinjun; Zhou, Hui; Deng, Hongxia; Song, Haoming; Yu, Xiuchong; Xiao, Bingxiu; Wang, Weihua; Guo, Junming

doi:10.1016/j.clinbiochem.2011.06.004

Cited by 192 publications

(134 citation statements)

References 36 publications

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“…Further studies revealed that both ARHGAP11A mRNA expression and invasiveness were concurrently increased in an in vitro cell line model. Cui et al [84] observed that the levels of piR-823 in peripheral blood from patients with gastric cancer were remarkably lower than those in healthy controls and the expression level of piR-823 were positively associated with tumor-node-metastasis stage and distant metastasis, suggesting piRNAs may be valuable biomarkers for detecting circulating gastric cancer cells. Subsequently, Cheng et al [85] found that overexpression of piR-823 could inhibited cancer cell growth.…”

Section: Introductionmentioning

confidence: 99%

“…This characteristic provides piRNAs an opportunity to pass through cell membrane easily instead of being degraded like other long RNAs and makes it detectable in patient samples like blood plasma and serum, saliva, sputum, and urine. A recent study found that piRNAs possess higher sensitivity and specificity compared to an existing miRNA-based biomarker detection system in gastric cancer [84]. Therefore, piRNAs are increasingly investigated to improve our understanding on the diagnosis of human cancers.…”

Section: Introductionmentioning

confidence: 99%

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PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Han

Xia

et al. 2017

Cell Physiol Biochem

127

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P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Han

Xia

et al. 2017

Cell Physiol Biochem

127

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“…On the contrary, expression of piR-832 in gastric cancer was considerably lower than in normal tissue and artifi cially increased levels of piR-832 inhibited the growth of gastric cancer cells [ 20 ]. Intriguingly, the peripheral blood levels of both piR-651 and piR-832 were signifi cantly lower in patients with gastric cancer than those of controls, implying piRNAs could be valuable biomarkers in diagnosing gastric cancer [ 21 ].…”

Section: Piwi-interacting Rnas (Pirnas)mentioning

confidence: 92%

Beyond miRNAs: Role of Other Noncoding RNAs in Cancer

Redis

Calin

2013

Non-Coding RNAs and Cancer

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Noncoding RNAs are by defi nition RNA molecules with a short open reading frame that are not translated into proteins. With hundreds of publications yearly, these new players have emerged as master regulators of multiple biological processes. One specifi c subset of ncRNAs, namely, microRNAs, received prevalent attention over the past decade, yet it forms only the tip of the iceberg. The noncoding RNA world is constantly expanding, whether it is by exploring novel classes of ncRNAs or by gaining further insight into their function. Noncoding RNAs are split in two main classes according to their size: short ncRNAs and long ncRNAs, each class encompassing various subclasses. In this chapter we focus on the most important subclasses of ncRNAs (e.g., piRNAs, snoRNAs, lincRNAs, T-UCRs), highlighting the illustrative examples. Furthermore, we discuss their potential involvement in therapy and diagnostics and what the future might reserve for these key regulators.

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“…These somatic piRNAs appear located in the nucleolus and in the cytoplasmic area surrounding the nuclear envolope and in contrast with the large population of known piRNAs in male germ cells, this population of piRNAs is dramatically smaller [174]. Another recent study demonstrated that the level of piR-651 is significantly higher in several cancer histotype including lung, mesothelium, breast, liver, and cervical cancer compared to non-cancerous adjacent tissues and inhibition of piR-651 induced block of gastric cancer cells at the G2/M phase [175,176]. Another example is represented by the downregulation of piR-823 in gastric cancer tissues; its enforced expression inhibited gastric cancer cell growth in vitro and in vivo, suggesting a tumor suppressive properties for piR-823 [177].…”

Section: Pirnas: Guardians Of the Genomementioning

confidence: 99%