2003
DOI: 10.3892/or.10.1.217
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Detection of CK19, CK20 and EGFR mRNAs in peripheral blood of carcinoma patients: correlation with clinical stage of disease

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Cited by 35 publications
(43 citation statements)
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“…In recent years, there have been many reports on the RT-PCR detection of CTCs in the peripheral blood, bone marrow, and/or peritoneal lavage of patients with gastrointestinal cancer (Pantel et al, 1999;Yamaguchi et al, 2000;Stathopoulou et al, 2002;Gradilone et al, 2003;Dandachi et al, 2005;Uen et al, 2006). Compared with bone marrow and lymph nodes, blood collection is a minimally invasive procedure and blood can be sampled throughout the course of the disease (Böckmann et al, 2001;Huang et al, 2003;Pantel and Alix-Panabières, 2010;Bednarz-Knoll et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
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“…In recent years, there have been many reports on the RT-PCR detection of CTCs in the peripheral blood, bone marrow, and/or peritoneal lavage of patients with gastrointestinal cancer (Pantel et al, 1999;Yamaguchi et al, 2000;Stathopoulou et al, 2002;Gradilone et al, 2003;Dandachi et al, 2005;Uen et al, 2006). Compared with bone marrow and lymph nodes, blood collection is a minimally invasive procedure and blood can be sampled throughout the course of the disease (Böckmann et al, 2001;Huang et al, 2003;Pantel and Alix-Panabières, 2010;Bednarz-Knoll et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…In previous studies, many target genes have been used to detect CTCs in gastrointestinal carcinoma, such as CEA, MUC1, hTERT, cMet, CK18, CK19, and CK20 (Soeth et al, 1997;Yamaguchi et al, 2000;Katsumata et al, 2006;Uen et al, 2006;Wu et al, 2006;Xi et al, 2007;Tsouma et al, 2008;Lagoudianakis et al, 2009). Cytokeratins are frequently used to detect the CTCs in peripheral blood (Weitz et al, 1999;Gradilone et al, 2003;Wang et al, 2006;Wang et al, 2007). The mRNAs of CK19 and CK20 have been successfully used to detect CTCs in the peripheral blood of patients with breast cancer, lung cancer, and gastrointestinal carcinoma (Mori et al, 1996;Denis et al, 1997;Peck et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…The intermediate filament CK19 has emerged as the PCR-marker of choice for microdisseminated breast cancer cells [8,[31][32][33][34][35]. CK19 is stably expressed in epithelial tissues and tumors but not usually in mesenchymal and/or haematopoietic cells [11,12]. Alternative markers tested by different groups have been Muc-1, urokinase type plasminogen activator receptor (uPAR), EpCAM and mammaglobin each originally considered breast cancer specific [36][37][38].…”
Section: Discussionmentioning
confidence: 99%
“…After the addition of the RNAstabilizer, samples were stored at minus 20°C until further analysis, allowing sample batching, which is important for routine clinical use. The intermediate filament CK19 has emerged as the PCR-marker of choice for microdisseminated breast cancer cells [8,[31][32][33][34][35]. CK19 is stably expressed in epithelial tissues and tumors but not usually in mesenchymal and/or haematopoietic cells [11,12].…”
Section: Discussionmentioning
confidence: 99%
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