Detection of colon cancer by terahertz techniques

Wahaia, Faustino; Valušis, Gintaras; Bernardo, Luı́s M.; Almeida, A.; Moreira, J. Agostinho; Lopes, Patrícia C.; Macutkevič, J.; Kašalynas, Irmantas; Seliuta, D.; Adomavičius, R.; Henrique, Rui; Lopes, Machado

doi:10.1016/j.molstruc.2011.05.049

Cited by 77 publications

(42 citation statements)

References 23 publications

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“…The terahertz (THz) spectroscopic technique, which is a novel medical imaging modality, 9 has received a attention for its benign nature (noninvasive and nonionizing) toward humans and its high sensitivity to biomolecules 10,11 and tissues. [12][13][14] In recent decades, the THz spectroscopic technique has been used to identify tumors on skin, [15][16][17] breast, [18][19][20] colon, [21][22][23] liver, 24 and other locations. All of the results show that the THz spectroscopic technique has potential for safely identifying disease in tissue samples.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the tissues studied by THz spectroscopy can be classified into three forms: fresh tissues, 12,13,16 frozen tissues, 26 and paraffin-embedded tissues. 23,24 The fresh tissues contain a large volume of water (THz absorption coefficient is about 240 cm −1 at 1 THz), 9 which contribute most to THz absorption in fresh tissues, while frozen tissues 26 and paraffin-embedded tissues 23,24 have much lower THz absorption than that of fresh tissues by excluding water. Tumors cannot be accurately differentiated from normal brain tissue by using only the water content.…”

Section: Introductionmentioning

confidence: 99%

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Terahertz pulsed spectroscopy of paraffin-embedded brain glioma

et al. 2014

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Abstract. The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2-to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Terahertz pulsed spectroscopy of paraffin-embedded brain glioma

et al. 2014

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“…The latter were presented generating 600 fs pulses [279], leading to a broadband spectrum up to 1.4 THz [280]. Within the biomedical field such pulsed terahertz sources have been used for the in-vitro detection of skin cancer, breast tumors or colon cancer [281][282][283][284][285][286]. The images showed a statistically significant contrast between cancerous and noncancerous tissue, resulting from differences in the water distribution and tissue structure.…”

Section: Diode Laser Systems Emitting Continuous Wave Terahertz Radiamentioning

confidence: 99%

“…The first biomedical application of such diode laser based CW systems has been imaging of a human liver with metastasis [7]. Other groups confirmed that CW-terahertz radiation represents a feasible alternative to pulsed systems in distinguishing between healthy and cancerous tissues [286,293].…”

Section: Diode Laser Systems Emitting Continuous Wave Terahertz Radiamentioning

confidence: 99%

Diode laser based light sources for biomedical applications

Müller

Marschall

Jensen

et al. 2012

Laser & Photonics Reviews

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Diode lasers are by far the most efficient lasers currently available. With the ever-continuing improvement in diode laser technology, this type of laser has become increasingly attractive for a wide range of biomedical applications. Compared to the characteristics of competing laser systems, diode lasers simultaneously offer tunability, high-power emission and compact size at fairly low cost. Therefore, diode lasers are increasingly preferred in important applications, such as photocoagulation, optical coherence tomography, diffuse optical imaging, fluorescence lifetime imaging, and terahertz imaging. This review provides an overview of the latest development of diode laser technology and systems and their use within selected biomedical applications. 670 nm external cavity diode laser for Raman spectroscopy built on a 13 × 4 mm 2 microbench (Copyright FBH/Schurian.com).

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“…Terahertz (THz) imaging technology has been a growing area of interest for biomedical applications. 1 For example, pulsed THz systems have been used to conduct imaging of liver cirrhosis, 2 osseous tissue damage, 3 and differentiation of cancerous tissues of the brain, 4 stomach, 5 colon, 6 and breast, 7-10 among others. However, imaging of breast and other cancers has been mostly limited to formalin-fixed, paraffin-embedded (FFPE) tissue to date, with only a few studies working with freshly excised tissue due to the challenges of obtaining fresh tissue outside of a surgical setting.…”

Section: Introductionmentioning

confidence: 99%

Pulsed terahertz imaging of breast cancer in freshly excised murine tumors

et al. 2018

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This paper investigates terahertz (THz) imaging and classification of freshly excised murine xenograft breast cancer tumors. These tumors are grown via injection of E0771 breast adenocarcinoma cells into the flank of mice maintained on high-fat diet. Within 1 h of excision, the tumor and adjacent tissues are imaged using a pulsed THz system in the reflection mode. The THz images are classified using a statistical Bayesian mixture model with unsupervised and supervised approaches. Correlation with digitized pathology images is conducted using classification images assigned by a modal class decision rule. The corresponding receiver operating characteristic curves are obtained based on the classification results. A total of 13 tumor samples obtained from 9 tumors are investigated. The results show good correlation of THz images with pathology results in all samples of cancer and fat tissues. For tumor samples of cancer, fat, and muscle tissues, THz images show reasonable correlation with pathology where the primary challenge lies in the overlapping dielectric properties of cancer and muscle tissues. The use of a supervised regression approach shows improvement in the classification images although not consistently in all tissue regions. Advancing THz imaging of breast tumors from mice and the development of accurate statistical models will ultimately progress the technique for the assessment of human breast tumor margins.

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Detection of colon cancer by terahertz techniques

Cited by 77 publications

References 23 publications

Terahertz pulsed spectroscopy of paraffin-embedded brain glioma

Terahertz pulsed spectroscopy of paraffin-embedded brain glioma

Diode laser based light sources for biomedical applications

Pulsed terahertz imaging of breast cancer in freshly excised murine tumors

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