Terahertz pulsed spectroscopy of paraffin-embedded brain glioma

Abstract

Abstract. The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2-to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.

Terahertz reflectometry imaging for low and high grade gliomas

“…Therefore, TRI may serve as a high-sensitivity detector for glioma, allowing neurosurgeons to ‘see’ tumor regions without the use of contrast agents during glioma surgery. Several papers reported on the possibility of glioma detection using TRI234041. However they used only fresh rat or paraffin-embedded samples.…”

Biomedical Applications of Terahertz Spectroscopy and Imaging

“…Paraffin-embedded tissues are frequently measured to reduce the influence of water, and numerous data revealed that cancer tissues display higher absorption coefficients ( Figure 2E) and refractive indexes than normal tissues [42,43]. However, cancerous gastric tissues exhibit higher absorption than normal tissues only at relatively low THz frequencies [44].…”

“…(E) Absorption coefficients of paraffin-embedded brain gliomas (red) and normal tissues (black). Absorption coefficients of glioma tissue were higher than those of normal tissue at frequencies below 1 THz, although the differences were not distinct at higher frequencies [43]. All figure panels were adapted, with permission, from the references indicated.…”

Terahertz Spectroscopic Diagnosis of Myelin Deficit Brain in Mice and Rhesus Monkey with Chemometric Techniques

“…THz spectroscopy has been applied to distinguish brain tumors 12–14 and neurodegenerative disorders, such as Alzheimer’s disease 15, 16 , but it probably more apply to myelin-associated disease. In 2004, with continuous-wave THz imaging technique, Darmo et al .…”