2001
DOI: 10.1016/s0306-4522(01)00137-3
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Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei – potential implication for arousal and attention

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Cited by 129 publications
(92 citation statements)
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“…The receptor subtype-specific antagonist CP154,526 did not cause a change in the basal FR but, because of its poor solubility, we could not evaluate whether the CRH effect could be completely blocked by this antagonist, and no clear dose-response relationship was observed with increasing doses of CP154,526. Nevertheless, CP154,526 did reduce the effect of CRH, suggesting that at least part of the response occurred via CRH 1 receptors; this is consistent with recent evidence demonstrating CRH 1 receptor immunoreactivity in the LC (Sauvage and Steckler, 2001;Fox et al, 2002;Xu et al, 2004) and the observation that systemic CP154,526 reduces intraventricular CRH-evoked increases in the LC FR (Schulz et al, 1996).…”
Section: Antagonists Of Crh Receptorssupporting
confidence: 88%
See 1 more Smart Citation
“…The receptor subtype-specific antagonist CP154,526 did not cause a change in the basal FR but, because of its poor solubility, we could not evaluate whether the CRH effect could be completely blocked by this antagonist, and no clear dose-response relationship was observed with increasing doses of CP154,526. Nevertheless, CP154,526 did reduce the effect of CRH, suggesting that at least part of the response occurred via CRH 1 receptors; this is consistent with recent evidence demonstrating CRH 1 receptor immunoreactivity in the LC (Sauvage and Steckler, 2001;Fox et al, 2002;Xu et al, 2004) and the observation that systemic CP154,526 reduces intraventricular CRH-evoked increases in the LC FR (Schulz et al, 1996).…”
Section: Antagonists Of Crh Receptorssupporting
confidence: 88%
“…CRH receptors are divided in two main classes (Hauger et al, 2003b;Bale and Vale, 2004), and at least some receptors in the LC are of the CRH 1 receptor subtype (Sauvage and Steckler, 2001). Recent ultrastructural evidence for CRH 1 receptors on LC neurons has also been reported (Fox et al, 2002;Xu et al, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Immunostaining for CRF-R1/2 receptors showed the same regional and cellular distribution reported previously in the murine brain, using the same antiserum (Chen et al, 2000;Sauvage and Steckler, 2001). In these experiments, specificity was demonstrated by the complete inhibition of staining after preadsorption Figure 2.…”
Section: Crf-r1/2 Receptor Immunoreactivity In Hypocretinergic Cell Bsupporting
confidence: 78%
“…The relevant sources of CRH to the mPFC remain to be determined. CRH inputs to the mPFC are known to derive from the laterodorsal tegmental nucleus of the pons, which contains cells that are co-localized for CRH and acetylcholinesterase (Crawley et al, 1985), as well as CRH-1 receptors and choline acetyltransferase (Sauvage & Steckler, 2001). Since cholinergic inputs to the mPFC influence attentional performance (Dalley et al, 2004), interactions between CRH and acetylcholine might influence attentional processes in stressed animals.…”
Section: Discussionmentioning
confidence: 99%