Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study

Hirose, Motohiko; Fukui, Hirokazu; Igarashi, Yoshinori; Fujimori, Yukari; Katake, Yoshinori; Ichikawa, Kazuhito; Tomita, Shigeki; Imura, Johji; Ajioka, Yoichi; Ueno, Hideki; Hase, Kazuo; Ohkura, Yasuo; Kashida, Hiroshi; Togashi, Kazutomo; Nishigami, Takashi; Matsui, Toshiyuki; Yao, Takashi; Wada, Ryo; Matsuda, Keiji; Watanabe, Toshiaki; Ochiai, Atsushi; Sugai, Tamotsu; Sugihara, Kenichi; Fujimori, Takahiro

doi:10.1007/s00535-010-0288-3

Cited by 18 publications

(18 citation statements)

References 24 publications

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“…In the multicenter collaborative studies led by the Japanese Society for Cancer of the Colon and Rectum (JSCCR) [1,6], we previously demonstrated that the biopsy specimens from Group B were frequently evaluated as DR-positive lesions. These pathological examinations were performed on sections stained with H & E. Thus, these studies revealed that it is possible to predict SM depth by diagnosis of pretreatment biopsy specimens, especially in non-pedunculated, but not in pedunculated CRCs.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, discrimination between M/SM1 CRC (Group A) and SM2 CRC (Group B) is very important for selecting therapeutic modalities against SM CRC. We also previously reported that the detection of desmoplastic reaction (DR) in pretreatment biopsy specimens was useful for predicting the SM depth in non-pedunculated, but not in pedunculated SM CRCs [1,6]. In these studies, DR was evaluated by hematoxylin and eosin (H&E) staining of the biopsy specimens, although it was difficult to diagnose DR in some cases of pedunculated CRCs [1].…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis of Desmoplastic Reaction by Immunohistochemical Analysis, in Biopsy Specimens of Early Colorectal Carcinomas, Is Efficacious in Estimating the Depth of Invasion

Ohno

Fujimori

et al. 2013

IJMS

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The aim of our study was to evaluate the diagnosis of desmoplastic reaction (DR) by immunostaining for α-smooth muscle actin (αSMA) and desmin, for predicting the depth of submucosal invasion in biopsy specimens of early colorectal carcinomas (CRCs). Thirty-eight cases of non-pedunculated early CRCs were included in this study. Positive for DR was defined as αSMA-positive and desmin-negative stroma in the CRC. The depth of submucosal invasion was measured in endoscopically or surgically resected specimens and the lesions were subsequently divided into two groups: Group A (carcinoma in situ/intramucosal carcinoma and submucosal invasive carcinoma with a depth <1000 μm) and Group B (submucosal invasion with a depth ≥1000 μm). Twenty-one cases were DR-positive and 17 were DR-negative. No statistical significance was found between the DR with regard to tumor size, location and histological type. All DR-positive cases belonged to Group B whereas 14 (82.4%) DR-negative lesions belonged to Group A (p < 0.001). The sensitivity, specificity, positive and negative predictive values and accuracy of DR positivity for diagnosis of Group B were 87.5%, 100%, 100%, 82.4% and 92.1%, respectively. Conclusively, detection of DR in biopsy specimens with ancillary immunohistochemistry (αSMA/desmin) would help in preoperative diagnosis for the depth of submucosal invasion of early CRC.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnosis of Desmoplastic Reaction by Immunohistochemical Analysis, in Biopsy Specimens of Early Colorectal Carcinomas, Is Efficacious in Estimating the Depth of Invasion

Ohno

Fujimori

et al. 2013

IJMS

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“…A retorospective study for detection of desmoplastic reaction in biopsy specimens of early colorectal cancer reported that 359 patients with SICRCs, who had undergone surgical or endoscopic mucosal resection, were analysed [23]. For pedunculated (Ip type) SICRCs was not significantly related to submucosal depth.…”

Section: Detection Of Desmoplastic Reaction In Biopsy Specimens Of Comentioning

confidence: 99%

“…Detection of DR in pretreatment biopsy specimens is useful for the prediction of submucosal depth in nonpedunculated (non-Ip) SICRCs, Table 7. Relationship between depth of submucosal invasion and DR in biopsy specimens of patients with SICRCsretorospective study -(adapted from [23])…”

Section: Detection Of Desmoplastic Reaction In Biopsy Specimens Of Comentioning

confidence: 99%

Desmoplastic Reaction in Biopsy Specimens of T1 Stage Colorectal Cancer Plays a Critical Role in Defining the Level of Sub-Mucosal Invasion

Tomita¹,

Ichikawa²,

Fujimori³

2013

Colonoscopy and Colorectal Cancer Screening - Future Directions

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“…However, a desmoplastic reaction (DR), characterized by stromal myofibroblast infiltration of the outermost layers of the tumor (8), is considered to be a response to the invasion of carcinoma cells beyond the muscularis mucosae into the submucosa (SM) or deeper layers (9). Detection of a DR may be useful for predicting massive SM invasion by colorectal carcinoma (10).…”

Section: Introductionmentioning

confidence: 99%

In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

Sugihara

Kudo

Miyachi

et al. 2017

Molecular and Clinical Oncology

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The pathological determination of desmoplastic reaction (DR) in colorectal carcinoma is useful for predicting extensive submucosal invasion. The aim of the present study was to determine the usefulness of endocytoscopy (EC) in detecting DR. A total of 72 cases of colorectal cancer with submucosal invasion (EC classification, EC3b) were evaluated. The utility of fine granular structure (FGS) observed via EC for the prediction of the presence of DR in the most superficial tumor layers was assessed. Of the 72 lesions, 26 were positive for FGS, and the majority of these lesions (23/26, 88.5%) exhibited a DR, indicating a significant association. The overall accuracy of the identification of FGS via EC that was predictive of a DR was 87.3%. The presence of FGS detected by EC was significantly associated with the presence of a DR, suggesting the clinical usefulness of EC in planning treatment for colon cancer with submucosal invasion.

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Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study

Abstract: Detection of DR in pretreatment biopsy specimens is useful for the prediction of SM depth in nonpedunculated SICRCs, and may be useful for the selection of such cases that would be treatable by endoscopic mucosal resection and endoscopic submucosal dissection (EMR/ESD).

Cited by 18 publications

References 24 publications

Diagnosis of Desmoplastic Reaction by Immunohistochemical Analysis, in Biopsy Specimens of Early Colorectal Carcinomas, Is Efficacious in Estimating the Depth of Invasion

Diagnosis of Desmoplastic Reaction by Immunohistochemical Analysis, in Biopsy Specimens of Early Colorectal Carcinomas, Is Efficacious in Estimating the Depth of Invasion

Desmoplastic Reaction in Biopsy Specimens of T1 Stage Colorectal Cancer Plays a Critical Role in Defining the Level of Sub-Mucosal Invasion

In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

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