In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

Sugihara, Yuusaku; Kudo, Shin‐ei; Miyachi, Hideyuki; Wakamura, Kunihiko; Mori, Yuichi; Misawa, Masashi; Hisayuki, Tomokazu; Kudo, Toyoki; Hayashi, Takemasa; Hamatani, Shigeharu; Okoshi, Shogo; Okada, Hiroyuki

doi:10.3892/mco.2017.1138

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…They established that EC is non-inferior to standard biopsy and could be used as an alternative for diagnosing colorectal neoplasia during routine colonoscopies ( 140 ). Several studies have utilized EC for predicting depth of invasion of colorectal cancer using endocytoscopic classification (based on the shape of the glands and lumens) ( 135 , 141 ), endocytoscopic-vascular pattern (EC-V) classification (based on the appearance surface micro-vessels) ( 142 ) or detecting desmoplastic reaction in tumor surface ( 143 ). All of them found EC to be highly accurate in predicting depth of invasion.…”

Section: Electronic Enhancing Techniques (Virtual Chromoendoscopy)mentioning

confidence: 99%

Image enhanced colonoscopy: updates and prospects—a review

Shahsavari¹,

Waqar²,

Chandrasekar³

2023

Transl Gastroenterol Hepatol

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Colonoscopy has been proven to be a successful approach in both identifying and preventing colorectal cancer. The incorporation of advanced imaging technologies, such as image-enhanced endoscopy (IEE), plays a vital role in real-time diagnosis. The advancements in endoscopic imaging technology have been continuous, from replacing fiber optics with charge-coupled devices to the introduction of chromoendoscopy in the 1970s. Recent technological advancements include “push-button” technologies like autofluorescence imaging (AFI), narrowed-spectrum endoscopy, and confocal laser endomicroscopy (CLE). Dye-based chromoendoscopy (DCE) is falling out of favor due to the longer time required for application and removal of the dye and the difficulty of identifying lesions in certain situations. Narrow band imaging (NBI) is a technology that filters the light used for illumination leading to improved contrast and better visibility of structures on the mucosal surface and has shown a consistently higher adenoma detection rate (ADR) compared to white light endoscopy. CLE has high sensitivity and specificity for polyp detection and characterization, and several classifications have been developed for accurate identification of normal, regenerative, and dysplastic epithelium. Other IEE technologies, such as blue laser imaging (BLI), linked-color imaging (LCI), i-SCAN, and AFI, have also shown promise in improving ADR and characterizing polyps. New technologies, such as Optivista, red dichromatic imaging (RDI), texture and color enhancement imaging (TXI), and computer-aided detection (CAD) using artificial intelligence (AI), are being developed to improve polyp detection and pathology prediction prior to widespread use in clinical practice.

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Section: Electronic Enhancing Techniques (Virtual Chromoendoscopy)mentioning

confidence: 99%

Image enhanced colonoscopy: updates and prospects—a review

Shahsavari¹,

Waqar²,

Chandrasekar³

2023

Transl Gastroenterol Hepatol

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“…28 The paper is commendable in that it is the first prospective study reported by a research team other than developers. Kudo et al also reported the efficacy for diagnosing sessile serrated lesion, 29 identification of desmoplastic reaction, 30 identification of tumor pathological grade, 31 prediction of the invasive depth of colorectal cancer, 32,33 and distinguishing low-grade from high-grade adenoma. 34 In all the aforementioned studies, the diagnostic performance was based on methylene blue staining, which is sometimes time-consuming and cumbersome.…”

Section: Ec For Colorectal Neoplasmsmentioning

confidence: 99%

Clinical Efficacy of Endocytoscopy for Gastrointestinal Endoscopy

et al. 2021

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EC) is a contact-type optical endoscope that allows in vivo cellular observation during gastrointestinal endoscopy and is now commercially available not only in Japan but also in Asian, European Union, and Middle Eastern countries. EC helps conduct a highly accurate pathological prediction without biopsy. Initially, EC was reported to be effective for esophageal diseases. Subsequently, its efficacy for stomach and colorectal diseases has been reported. In this narrative review, we searched for clinical studies that investigated the efficacy of EC. EC seems to accurately diagnose gastrointestinal diseases without biopsy. Most of the studies aimed to clarify the relationship between endocytoscopic findings of gastrointestinal neoplasia and pathological diagnosis. Some studies have investigated non-epithelial lesions or diseases, such as inflammatory bowel disease or infectious diseases. However, there are few high-level pieces of evidence, such as randomized trials; thus, further studies are needed. Clin Endosc 2021 Jul 7.

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“…The overall accuracy of the identification of FGS via EC that was predictive of a DR was 87.3%. 55 Utsumi et al prospectively analyzed 63 diminutive polyps and concluded that EC has the potential to be used for "real-time histopathology" with high diagnostic accuracy for differentiating neoplastic from non-neoplastic colorectal diminutive polyps (5 mm), and showed that the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 98.0%, 92.3%, 96.8%, 98.0%, and 92.3%, respectively. 56 A unique study conducted by Kudo et al in 2019 revealed EC features that could be used as indicators of low-grade adenoma, such as a normal pit sign (NP), to implement the resect and discard strategy by assessing 748 lesions of colorectal adenoma by EC.…”

Section: Colonic Polyps and Cancermentioning

confidence: 99%