Detection of DNA Damage Measured by Comet Assay in Pre and Post Chemotherapeutic Acute Lymphoblastic Leukaemia

Halder, Arijit; Bandyopadhyay, Debasis; De, Madhusnata; De, Manisha

doi:10.1080/09723757.2002.11885808

Cited by 3 publications

(2 citation statements)

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“…Halder et al (2002) also observed severe degree of damage of DNA at the relapsed stage of post chemotherapy induced patients with little or no immature cells seen in peripheral blood and bone marrow, supporting a short term benefits of chemotherapy alone. Wolf et al (1991) also demonstrated that there is no significant difference in survival between patients having induction chemotherapy and radiation verses surgery and radiation in respectable advanced stages squamous cell carcinoma of the larynx.…”

Section: Resultsmentioning

confidence: 85%

Assessment of Tumour Response to Multimodalities of Treatment in Locally Advanced Breast Cancer Patients Using Comet Assay

Santhy

Anupama

Srividya

et al. 2009

International Journal of Human Genetics

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The present study has been carried out to evaluate tumour response to the multi-modalities of treatment using comet assay in breast cancer patients and to assess the efficacy of combinatorial therapy over single modality treatments. An effort was also made to correlate the extent of DNA damage with the cycles of chemotherapy given. A positive correlation was found with the selected comet parameters.

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Section: Resultsmentioning

confidence: 85%

Assessment of Tumour Response to Multimodalities of Treatment in Locally Advanced Breast Cancer Patients Using Comet Assay

Santhy

Anupama

Srividya

et al. 2009

International Journal of Human Genetics

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“…Kopjar et al, (2002) used the comet assay to evaluate the genotoxicity of different types of chemicals used as drugs towards human peripheral lymphocytes they found that high toxicity was detected among exposed cells as compared with control group. Such toxicity was also detected in ALL patients treated with these chemicals (Halder et al, 2002). High base line level of DNA damage may also point to an impaired…”

Section: Results and Discussion Micronucleusmentioning

confidence: 94%

Genetic Alterations in Iraqi Leukaemia Patients as Indicator for Polluted Environment

Al-Faisal¹,

Al-Amili²,

Ali³

2014

ETJ

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Amlodipine-Induced Testicular Dna Damage and Its Modification by a Herbal Preparation in Wistar Albino Rats

Dominic¹,

Padmaja²

2021

IND. DRU.

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The present study originated from the reports of adverse effects on male reproductive potential caused by the dihydropyridine derivative type calcium channel blockers, which are widely used agents for different cardiovascular disorders. The study was conducted to verify whether the repeated administration of this type of calcium channel blockers can cause any testicular DNA damage and if so, whether the damage can be modified by the co-administration of a herbal protective agent. The study was conducted in male Wistar albino rats. The testicular DNA damage of different groups of rats was evaluated by comet assay taking percentage DNA in comet tail as the main parameter. It was found that oral administration of the widely used dihydropyridine type calcium channel blocker amlodipine produced a duration- dependent and significant (P<0.001) DNA damage in the testes of Wistar albino rats. The co- administration of the alcoholic extract of seeds of Asteracantha longifolia produced a dose dependent and significant ((P<0.001) protective effect against this amlodipine-induced testicular DNA damage.

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Detection of DNA Damage Measured by Comet Assay in Pre and Post Chemotherapeutic Acute Lymphoblastic Leukaemia

Cited by 3 publications

References 0 publications

Assessment of Tumour Response to Multimodalities of Treatment in Locally Advanced Breast Cancer Patients Using Comet Assay

Assessment of Tumour Response to Multimodalities of Treatment in Locally Advanced Breast Cancer Patients Using Comet Assay

Genetic Alterations in Iraqi Leukaemia Patients as Indicator for Polluted Environment

Amlodipine-Induced Testicular Dna Damage and Its Modification by a Herbal Preparation in Wistar Albino Rats

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