Detection of Dobrava hantaviruses in Apodemus agrarius mice in the Transdanubian region of Hungary

Jakab, Ferenc; Horváth, Gyula; Ferenczi, Emöke; Sebők, Judit; Varecza, Zoltan; Szücs, György

doi:10.1016/j.virusres.2007.04.015

Cited by 22 publications

(16 citation statements)

References 10 publications

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“…11 Recently, DOBV was detected in patients and in Apodemus mice in Hungary. 12,13 Here, we report the first case of a patient infected with DOBV, presenting with early symptoms mimicking acute appendicitis, i.e. a rare and easily misleading clinical picture.…”

Section: Why This Case Is Important?mentioning

confidence: 97%

Dobrava–Belgrade hantavirus infection mimics acute appendicitis

Jakab

Sebők

Szántó

et al. 2011

Journal of Clinical Virology

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Section: Why This Case Is Important?mentioning

confidence: 97%

Dobrava–Belgrade hantavirus infection mimics acute appendicitis

Jakab

Sebők

Szántó

et al. 2011

Journal of Clinical Virology

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“…Later on, case reports and clinical studies revealed that DOBV was often found as a causative agent of identified hantavirus infections in the country [15][16][17]. The circulation of DOBV in Hungary was proven by molecular methods already in 1995 and somewhat later, the circulation of 3 DOBV genotypes was confirmed [18][19][20]. In 2008, the presence of TULV was also verified in the Transdanubian region by molecular methods in Microtus arvalis voles [21].…”

Section: Volunteers and Samplesmentioning

confidence: 99%

Serosurvey of pathogenic hantaviruses among forestry workers in Hungary

Oldal¹,

Németh²,

Madai³

et al. 2014

IJOMEH

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Objectives: The aim of the study was to survey the prevalence of human hantavirus infections among forestry workers, who are considered a risk population for contracting the disease. Sera collected from volunteers were tested for antibodies against Dobrava-Belgrade (DOBV) and Puumala (PUUV) viruses. Material and Methods: For serological analyses, full capsid proteins of DOBV and PUUV viruses were produced in a bacterial expression system, while Ni-resin was used for protein purification. Samples were screened for anti-hantavirus antibodies by ELISA, results were confirmed by Western blot analysis. Results: A total of 835 samples collected from 750 males and 85 females were tested by indirect ELISA and positive test results were confirmed by Western blot assay. Out of the 45 ELISA-reactive samples, 38 were confirmed by Western blot analysis. The regional distribution of seropositive individuals was as follows: 1.9% (2/107) in the Danube-Tisza Plateau (Great Plains), 3.1% (10/321) in the Southern Transdanubian region, 5.2% (13/248) in the Northern Transdanubian, and 8.2% (13/159) in the North Hungarian Mountains. Conclusions: Our data show marked geographic differences in seroprevalence of pathogenic hantaviruses within Hungary, indicating elevated exposure to hantavirus infections in some areas.

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“…In addition to Slovakia and Germany, in Central Europe the DOBV-Kurkino genotype has so far been detected only in Hungary (Scharninghausen et al, 1999;Jakab et al, 2007a;Plyusnina et al, 2009).…”

Section: Dobrava-belgrade Virusmentioning

confidence: 99%

The broad spectrum of hantaviruses and their hosts in Central Europe

Klempa¹,

Radosa²,

Dh³

2013

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Summary. -Hantaviruses are considered to be emerging viruses due to their increasing significance as human pathogens and their cyclic reappearance during outbreaks. Central Europe is an important endemic region for hantavirus infections. Reflecting the presence of all relevant small mammals serving as reservoir hosts, close to all recognized European hantaviruses occur also in Central Europe. Important human pathogens, Puumala and Dobrava-Belgrade viruses, are present and cause hemorrhagic fever with renal syndrome of various severities. Moreover, several of the newly recognized shrew-and mole-borne hantaviruses are present. In this review, we summarize current data on molecular detection of hantaviruses in reservoir hosts as well as on molecular epidemiology of human hantavirus infections in Central Europe.

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Detection of Dobrava hantaviruses in Apodemus agrarius mice in the Transdanubian region of Hungary

Cited by 22 publications

References 10 publications

Dobrava–Belgrade hantavirus infection mimics acute appendicitis

Dobrava–Belgrade hantavirus infection mimics acute appendicitis

Serosurvey of pathogenic hantaviruses among forestry workers in Hungary

The broad spectrum of hantaviruses and their hosts in Central Europe

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